Excited that our paper was featured! It was exciting to bring together advanced imaging and physiology to uncover this hidden layer of communication in brain cells.

Thrilled to see our paper highlighted in @ptrrupprecht.bsky.social blog post! The ER helps carry Ca2+ signals not just within dendrites but also across tiny spines, the main sites of synaptic input. This means that spines can be connected through the ER. gcamp6f.com/2025/08/11/i...

Extremely honored and humbled to be part of the 2025 Leading Edge Court. Grateful for the opportunity to join this inspiring community of scientists pushing the boundaries of discovery. Looking forward to learning, connecting, and growing together! 🌟 #LeadingEdge2025 #WomenInScience #hhmi #janelia

Cool new #optogenetic tool developed to disassemble intermediate filaments 🤩

What started as a brief chat with @buvansr.bsky.social and @vgelfand.bsky.social at the 2023 CellBio meeting @ascbiology.bsky.social has grown into our published collaborative work on single vimentin IF dynamics and organization in cells. Love when stuff like that happens.

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

🔬 Researchers from the Shroff Lab & collaborators have developed a new method to simultaneously image the 3D orientation & position of biomolecules, giving scientists a new view into how structures are arranged inside cells. 🔗 www.janelia.org/news/new-ima...

New insights into the mysterious spine apparatus from the super talented @haniehfalahati.bsky.social

💪New research led by @lorenabenedetti.bsky.social in the Lippincott-Schwartz Lab shows that subcellular structures similar to those that propagate signals that make muscles contract also transmit signals in the brain that may facilitate learning & memory 🧠 🔗 https://hhmi.news/4jMHbNY

This #FluorescenceFriday video shows 89 volumes from the #HHMIJanelia FlyLight Split-GAL4 collection: premotor and related neurons from the #Drosophila fruit fly's equivalent of a spinal cord. I gave a high-level description of the video to neuVid, which drove rendering by VVD Viewer.

Check out the stunning movie by @xianglejerry.bsky.social from @wumin-lab.bsky.social, the winner of the 2024 ASCB Video Contest! Traveling waves of FBP17-EGFP at the cortex of immune mast cells #ASCB2024 @ascbiology.bsky.social

This video was fun. I matched the #Neuroscience segmentations shown first (from the #HHMIJanelia FlyEM team) to the #CellBiology segmentations shown later (from Alyson Petruncio, @herrsaalfeld.bsky.social and the CellMap team). I described the animation with neuVid and rendered it with #Blender.

Congratulations to @lorenabenedetti.bsky.social and colleagues @jls_lab.bsky.social for this beautiful work revealing the role for periodic ER-PM junctions in propagating long range Ca²⁺ signaling along dendrites.

I was amazed to see this beautiful work at @hhmijanelia.bsky.social a few months ago - happy to see it out! The ER as an integral actor of neurotransmission 🤯

First heard of this at the cell biology of the neuron #GRC. It was such a great study with beautifully executed experiments. Congrats to everyone involved!

Very cool work on ER/PM junctions in neurons and how they regulate VGCCs. #neuroskyence

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

Learn about the periodic ER organization along neurites in insects and vertebrates and its potential role in long-range Ca2+ signal integration www.sciencedirect.com/science/arti... by the fabulous @lorenabenedetti.bsky.social and friends.

It was such a pleasure to host you both at our #CellBio2024 #SciArt Show & Reception! Thank you for making this event so special, and for bringing your creativity and enthusiasm to our community 😍

Really bummed to have missed ASCB this year due to some last-minute circumstances, but excited that our manuscript describing an IF disassembly tool will (hopefully) be posted soon. Here's a movie of vimentin color-coded by orientation.

ASCB President Sandra Murray with our 2024 Mentoring Keynote, Sonya Neal, Associate Professor, HHMI Freeman Hrabowski Scholar, UC San Diego, HHMI #CellBio2024

Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳

🚨For the lucky colleagues attending #CellBio2024 in San Diego, check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! A fantastic lineup covering the latest across the field. See you there! **Please RT** 🥳 t.co/6eq3cyGlVZ

#CellBio2024, the joint meeting of ASCB and EMBO, will take place December 14-18, 2024, in San Diego, California. Join us to connect with scientists, present your research, and explore the latest advancements in cell biology science and technology. www.ascb.org/cellbio2024/

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

In honor of our annual ChemisTree event @hhmi.bsky.social @hhmijanelia.bsky.social today, here's a repost of a little video I made a few years back to demonstrate how the ornament silver plating works! #chemsky

Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!

and a nice cover article from @science.org on our work. www.science.org/content/arti...

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!

Two exciting #MembraneSeminars this week! Thu, 5 Dec 5.00 PM CET / 11.00 AM EST Jonathon Nixon-Abell (CIMR, Univ. Cambridge, UK) Protein-lipid phase coupling in lysosomal transport Itay Budin (UCSD, CA, USA) New tools for visualizing lipid trafficking between and across organelle membranes

Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨