We keep on investigating the cellular properties of the molecular helicase PhpC we developed to unfold G-quadruplex #G4 DNA and RNA. In this new preprint, we demonstrate its genoprotective properties, showing how PhpC mitigates G4-associated genetic instability. 👉 doi.org/10.64898/202...

The DNA damaging properties of the experimental G-quadruplex (G4) drug QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC https://www.biorxiv.org/content/10.64898/2026.02.06.704351v1

Biocatalysts made of DNA, and G-quadruplex #G4 DNA in particular, have found a myriad of applications. But is there a real-life application reported so far? Thrilled to report this long-awaited example with the remediation of industrial wastewater! In @academic.oup.com doi.org/10.1093/nsr/...

FYI: the molecular helicase PhpC we developped to unfold G-quadruplex #G4 DNA and RNA both in vitro (see: shorturl.at/Ep8Il) and in human cells (e.g., shorturl.at/ue7rV, shorturl.at/zsheP & shorturl.at/MfUKW) is now commercially available at Idylle @idylle-labs.bsky.social 👉 shorturl.at/efE5l

Happy to be one of these guys going down the White Dune before swimming 10k across the Dakhla bay. 4 days, 4 stages, 4 adventures. Thank you Morocco Swim Trek 🙏 👉 moroccoswimtrek.com

How to recapitulate in vitro what happens in cells? Not easy! We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation With Nanjing U & @polytechniqueparis.bsky.social @cnrs.fr In @narjournal.bsky.social: doi.org/10.1093/nar/...

A huge thank you to Jean-Louis Mergny, Jérome and Pascale @polytechniqueparis.bsky.social for organizing the "G-quadruplex (G4) made in France": two days filled with diverse and fascinating exchanges on the many facets of #G4 research!

Super proud of my team! They have simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s. The TASQs story: doi.org/10.1021/acs.... This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...

A novel biotechnological application for G4s, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner Now in Anal. Chem. @pubs.acs.org With Nanjing U. & @polytechniqueparis.bsky.social @cnrs.fr doi.org/10.1021/acs....

The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down) In ACS Bio & Med Chem Au: doi.org/10.1021/acsb... With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)

Stimulating scientific days #ChemBioParis2025. Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com

We’ve developed the first-ever method to control nucleic acid activity and gene-expressing synthetic cells with a deeply tissue penetrating alternating magnetic field 🧬 🧪 🧲!!! Published in *Nature Chemistry* Led by Ellen Parkes @syncelleu.bsky.social #chemsky www.nature.com/articles/s41...

What happens when a DNA-junction binding compound is lengthened? Intriguingly, the larger pi surfaces widen the range of junctions targeted! Just out in JBIC -congratulations to authors Sam and Hannah -first paper from her MSc by research studies @uobchemistry.bsky.social doi.org/10.1007/s007...

Honored to have been interviewed by Pour La Science, a wide-audience scientific magazine, to discuss the results from @simonelsasser.bsky.social / @puckknipscheer.bsky.social published in @science.org about how DNA repair proteins mold G-quadruplex #G4 👉 tinyurl.com/3k6pxu6d (sorry, in French only)

Happy to describe a novel strategy to detect pollutants in food with a super high sensitivity, using G-quadruplex #G4 based biosensing devices. A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR) Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....

Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC. A collaboration with ITTGN (India) and supported by @embo.org fellowships Now in BMC Biol.: doi.org/10.1186/s129...

Ready for super-G4s? We have identified clusters of G4s in intergenic regions that act as super-enhancers in ovarian cancer cells, hence the name super-G4! These are de novo super-enhancers that are not underpinned by canonical epigenetic marks, supporting the epigenetic role of G4s rdcu.be/evXtf

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) we developed in the lab In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social ‬ 👉 doi.org/10.1016/j.ij...

Call for Expressions of Interest – MSCA Postdocs 2025 Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”. Deadline: June 15 www.usc.es/ciqus/en/MSC... #MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky

The best of the best! The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others Thank you again for your participation!

It was an absolute thrill and a real pleasure to organize the first meeting on #DNA #RNA junctions in Paris. Fantastic talks, lively discussions—and some excellent wine too! 🍷😁 A very promising beginning for this new community Stay tuned—we’ll be back next year! #IMAJ1 #CNRSchimie @cnrs.fr

The first IRN on Nucleic Acid Junctions meeting couldn’t have gone any better. Brilliant science, inspiring people, and a perfect atmosphere. Huge thanks to @dmonchaud.bsky.social for making it happen #IMAJ1 #ChemSky #DNAjunctions

Thank you, Miguel! It was great to have you all here in Paris. It was our first meeting, but it was so exciting and promising! I'm eager to repeat this beautiful experience next year, certainly in the UK! Stay tuned! #DNA #DNAjunction #iMAJ #IRN

A project five years in the making, we've now published complete "T2T" genomes for six additional ape species! It turns out that finishing (and analyzing) six genomes is slightly more work than one... doi.org/10.1038/s415...

Excited to present our new @naturecomms.bsky.social paper with Stefania Millevoi's lab on the role of #RNA G-quadruplex in mitochondrial RNA. We find that #RG4 can be exploited to inhibit mitochondrial translation and disrupt #cancer cells proliferation. www.nature.com/articles/s41...

We're thrilled to have contributed to this @naturecomms.bsky.social paper on the role of G-quadruplex #G4 in mitochondrial RNA G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate This is huge! 👉 doi.org/10.1038/s414...

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

Have a look at our newest commentary in @pnas.org : "G-quadruplexes and their unexpected ability to fold proteins" Full text: www.pnas.org/doi/10.1073/... #G4 #quadruplex #proteins #folding

In case you missed it, you can now watch the excellent 2025 Francis Crick Lecture from Shankar Balasubramanian on our YouTube channel! Shankar delivered an excellent talk on ‘The DNA Quadruplex Helix’ – it’s not one to miss! youtu.be/RIDAP0Ds2yo

Welcome to BlueSky @jamchemsoc.bsky.social ! Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner #chembio #AcademicSky #SciSky

Versatile Click Chemistry-based Approaches to Illuminate DNA and RNA G-Quadruplexes in Human Cells Work by Angélique Pipier and @dmonchaud.bsky.social at ICMUB - Institut de Chimie Moléculaire de l'Université Bourgogne Europe. #LifeSciences #Reproducibility #MolecularBiology

A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social Interested?? All you need is: - the clickable ligand: www.sigmaaldrich.com/FR/en/produc... - and the protocol: doi.org/10.21769/Bio...

Quite happy to see this out in @chemistryeurope.bsky.social (with ENS Paris FR, Szeged University HU, UTC Prague CZ) We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties. 👉 doi.org/10.1002/cmdc...

The place to be!

A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41... & G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...

Really excited to see this work out! In collaboration with Prof. Jen Prescher, we showed that their cyclopropenone labeling strategy can be applied to structured RNA! Thrilled to work with this fantastic team of scientists. pubs.acs.org/doi/10.1021/...

One of the ones I am most proud of. In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells. 👉https://dx.doi.org/10.1016/j.jbc.2024.108040 @cnrs.bsky.social

📢 New @natrevmcb.bsky.social Review! Jan Karlseder et al. discuss telemore (dys)function in ageing & disease, and efforts to generate a humanised mouse model for telomere research. go.nature.com/3ZxZuhS #NatRevMCB

My (little) contribution to make the field of G-quadruplex #G4 ligands accessible to all.. .. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology. A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉 👉 doi.org/10.1007/s000...

welcome @valeriegabelica.bsky.social !

Bienvenu @pbelmont.bsky.social !

Hi DNA/RNA folks! With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie! 1st meeting next year (May 25) in Paris Contact me if interested

.. by the way, I also created starter pack focused on DNA and RNA G-quadruplexes #G4 and included some buddies @sebastien-britton.bsky.social @granzhan.bsky.social @drzoewaller.bsky.social @paeschkelab.bsky.social @jschneek.bsky.social Contact me if interested! go.bsky.app/4VgiGa4

So, what are we doing? (1/3) To decipher DNA and RNA G-quadruplex #G4 biology, chemical biology investigations rely on specific molecular tools to prevent off-target effects and misinterpretations of molecular mechanisms. We are developing such tools for several years now: doi.org/10.1021/acs....

So let's talk about chemical biology! But what is it all about exactly? A thread (1/4) The notion of chemical biology (and of chemical genetics) was initially discussed between Linus Pauling and George Beadle as of 1945 and published in 1954 (Eng. Sci. 1954, 17, 9)

Hi Bluesky! New here and a bit surprised not to see a starter pack dedicated to Chemical Biology so.. here we go! go.bsky.app/DDpDuvo