Our study shows Ephrin A1 undergoes conformational selection when binding EphA2, while its juxtamembrane regions stay flexible. These insights clarify bidirectional signaling and may guide future therapeutic strategies. Full text: www.sciencedirect.com/science/arti... #NMR #Ephrin #Cancer #receptor

Great contribution from our former lab member Robert Silvers in @narjournal.bsky.social ☺️ "Noncanonical RNA binding of human La-related protein 6" Full text: academic.oup.com/nar/article/... #LARP #NMR #RNA #structure

Take a look at the publication of our former lab member Nina Kubatova in @pnas.org 😇 "Dimerization propensity of the β1-adrenergic receptor in lipid nanodiscs probed by DEER and single-molecule spectroscopies" Full text: www.pnas.org/doi/10.1073/... #DEER #protein #SingleMolecule #GPCR

Together with the Evanseck Lab, our lab just published the NMR + MD structure of the Omicron SARS-CoV-2 s2m RNA, revealing a pentaloop with remarkable dynamics. Full text: m.rnajournal.cshlp.org/content/earl... #NMR #MD #RNA #SARSCoV2 #structure #dynamics

At the 2025 meeting of the German focus group of Magnetic Resonance (FGMR, EPR/NMR), Harald Schwalbe, Instruct-director, introduced access possibilities and highlighted the recent installation of the German Instruct centre. @instruct-eric.bsky.social @gdch.de #NMR #EPR #FGMR #GDCh #InstructERIC

Exciting work from Duchardt-Ferner et al. in NAR: high-res. NMR structure of a tobramycin-responsive riboswitch. Shows a novel aminoglycoside-binding RNA motif with unique RNA-RNA contacts, explaining its exceptional switching efficiency in eukaryotic translation. academic.oup.com/nar/article/...

Instruct Director Harald Schwalbe will be in Denmark for the SBiNLab’s 25th anniversary! www1.bio.ku.dk/english/rese... @schwalbe-lab.bsky.social Researchers in Denmark can receive access to Instruct technologies and instrumentation here - instruct-eric.org/submit-propo...

Our newest publication is online! Using fragment-growth guided by NMR spectroscopy, we optimized small molecules targeting SCoV-2 SL1 RNA, integrating solubility, affinity, and specificity to identify translation inhibitors. Full text: pubs.acs.org/doi/10.1021/... #NMR #drugdesign #RNA #SARSCoV2

Check out our newest chemical shift assignment! 🎉 We used NMR to characterize the SL5a stem-loop from HCoV-229E, a conserved RNA element key to coronavirus RNA translation and replication. doi.org/10.1007/s121... #RNA #NMR #Virology #StructuralBiology #Assignment #Coronavirus

RT @euromar2025 EUROMAR 2025 opens in Oulu A fantastic lineup of prize winners: 🏆 Prof. Thomas Prisner – Richard R. Ernst Prize 🏆 Dr. Nergiz Sahin Solmaz – Raymond Andrew Prize 🏆 Prof. Tuo Wang – Ampere Prize for Young Investigators Congratulations to all! #EUROMAR2025 #NMR #EPR #MRI #ESR #NMRchat

Workshop Alert: On July 10, Nathalie Weickgenannt and Laura Buglioni from @angewandtechemie.bsky.social will be at Goethe University Frankfurt to host a Wiley Publishing Workshop. Don’t miss this opportunity to gain valuable insights into scientific publishing!

New publication is out in @febsopenbio.bsky.social ! 🎉 "NMR screening of low molecular weight inhibitors targeting the papain-like protease (PLPro) of SARS-CoV-2" Full text: febs.onlinelibrary.wiley.com/doi/10.1002/... #screening #NMR #SARS-CoV2 #targeting

New publication in @narjournal.bsky.social - Using NMR, SAXS & MD, we characterize the dynamic nonaloop of the SARS-CoV-2 Delta s2m RNA, contributing to future ensemble-functional studies of dynamic RNA motifs. Full text: doi.org/10.1093/nar/... #RNA #StructuralBiology #NAR #NMR #MDSimulations

Let's support the Bethesda Declaration and stand up for science together ✍️ actionnetwork.org/petitions/op...

A great overview of methods to investigate RNA modifications 😊 onlinelibrary.wiley.com/doi/full/10....

Prof. José María Carazo has been elected Chair of the Instruct-ERIC Council, with Dr. Evangelia Chrysina as Vice-Chair. Both bring structural biology expertise to further develop European research infrastructure. @instruct-eric.bsky.social instruct-eric.org/news/instruc...

Another publication on DNA G-quadruplexes in collaboration with the Heckel group is out! 🎉 "Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter" Full text: pubs.acs.org/doi/10.1021/... #G4 #quadruplex #photocages #NMR #VEGF #structure

New publication from Robert Silver's lab reporting the NMR assignment of the 5'SL-bound La domain of human La-related protein 6 (HsLARP6). Congratulations! Full text: link.springer.com/article/10.1...

Congratulations to Hashim Al-Hashimi on his election to the American Academy of Arts and Sciences! We are thrilled to see his outstanding work being recognized. 🔗 news.columbia.edu/news/three-c...

Check out our latest assignment note 🥳 'NMR characterisation of the antibiotic resistance-mediating 32mer RNA from the 23S ribosomal RNA' Full text: link.springer.com/article/10.1... #NMR #RNA #m6a #Erythromycinmethyltransferase

Check out our latest publication on DNA G-quadruplexes! We show how the ligand Phen-DC3 modulates the folding of the human telomeric repeat 23TAG DNA, providing insights into the modulation of G4 folding. Read more here 👉 doi.org/10.1002/chem... #DNA #GQuadruplex #folding #kinetics #realtime #NMR

Two of our publications are among the most widely read papers in Chemistry and ChemMedChem! 🤩🎉 #EPHA2 #colorectalcancer #drugdiscovery Full text here: chemistry-europe.onlinelibrary.wiley.com/doi/full/10.... chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

The newest collaboration project has been published! Congrats to the group of @m-grininger.bsky.social 🥳 'Protocol for the purification, analysis, and handling of acyl carrier proteins from type I fatty acid and polyketide synthases' Full text link: www.sciencedirect.com/science/arti...

In February 2025, Instruct-ERIC Director Prof. Harald Schwalbe visited the Instruct-ERIC center in Israel. Visit here for the full report: instruct-eric.org/news/focus-o...

Fragment-Screen Coordinator Prof. Harald Schwalbe @schwalbe-lab.bsky.social, and Jose Maria Carazo @cnb-csic.bsky.social, at the @elixir-europe.org 3DBioinfo conference, outlining the data management possibilities and collaborations available in fragment based drug discovery fragmentscreen.org/home

🎓 PhD Opportunity at DTU! 🎓 Join the TargetRNA MSCA doctoral network to advance RNA-ligand design with NMR & X-ray crystallography! 🌍🔬 Apply by: 2 April 2025 📍 Kemitorvet, Kgs. Lyngby, 2800, Denmark 🔗 Apply now: efzu.fa.em2.oraclecloud.com/hcmUI/Candid... #PhD #NMR #RNAResearch #JobAlert #DTU

Have a look at our newest commentary in @pnas.org : "G-quadruplexes and their unexpected ability to fold proteins" Full text: www.pnas.org/doi/10.1073/... #G4 #quadruplex #proteins #folding

Check out the newest publication from our group: "Nanosecond Hyperquenching, a Novel Method of Specimen Preparation for Electron Cryo-Microscopy" Full text: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... #time-resolved #ECM #NHQ

We are delighted to reveal that we have been announced as winners of the Gender Equality Newcomer Award by the European Commission!

Director @schwalbe-lab.bsky.social has visited Instruct-IL this week: - Yesterday, an intense discussion and Seminar on integrated structural biology - Today a visit to Israel ministry of Science - And tomorrow, a visit of Life Science facilities in Israel! instruct-eric.org/centres/inst...

A new NMR assignment letter is online! Take a look at the secondary structure of the E.coli guanidine-II riboswitch! Full text: doi.org/10.1007/s121... #nmr #RNA #riboswitch #structure

Congratulations to Betül and co-workers for this great work 🥳 "Optimization of Structure-guided Development of Chemical Probes for the Pseudoknot RNA of the Frameshift Element in SARS-CoV-2" Full text: doi.org/10.1002/anie... #nmr #SARS-CoV2 #rna #drugtargeting

The second day of the #ERICForum meeting starts with a #EOSC theme round table chaired by @instruct-eric.bsky.social director Prof Harald Schwalbe