Xin Gu Lab at DFCI/HMS
@xingulab.bsky.social
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Enthusiastic about transcription factor turnover!
Super excited to contribute to this special interest subgroup!!! Thank you for this opportunity, Abby and Iain!
add a skeleton here at some point
about 1 month ago
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Xin Gu Lab at DFCI/HMS
Klingenstein Philanthropies
6 months ago
Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System."
@xingulab.bsky.social
xingulab.dana-farber.org
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Xin Gu Lab at DFCI/HMS
Harvard Med Cell Biology
7 months ago
New work from
@xingulab.bsky.social
@sshaolab.bsky.social
& Elledge lab report structure of Midnolin-proteasome complex & its role in controlling myeloma via ubiquitin-independent degradation.
www.cell.com/molecular-ce...
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Nardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00469-1
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Xin Gu Lab at DFCI/HMS
Dana-Farber News
7 months ago
A new study in Molecular Cell led by @danafarber.bsky.social’s Xin Gu, PhD, highlights midnolin as a key regulatory component of proteostasis in plasma cells and suggests that restoring or enhancing this pathway could represent a novel therapeutic avenue in myeloma treatment.
bit.ly/4l8Zuwu
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So happy and proud to see our story online!! Thank you, the midnolin team!
add a skeleton here at some point
7 months ago
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Xin Gu Lab at DFCI/HMS
Susan Shao
10 months ago
~1 week left to register for the EMBO workshop on RNA meets protein decay!
#EMBOrnaDecay
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
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RNA meets protein decay
Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…
https://meetings.embo.org/event/25-rna-decay
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Xin Gu Lab at DFCI/HMS
Eilika Weber-Ban Lab
11 months ago
👏 Another chapter in the midnolin proteasome story from
@xingulab.bsky.social
www.biorxiv.org/content/10.1...
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...
https://www.biorxiv.org/content/10.1101/2025.02.22.639686v1
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Xin Gu Lab at DFCI/HMS
Susan Shao
11 months ago
Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!
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Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab
@sshaolab.bsky.social
and all the co-authors who put in the hard work!
www.biorxiv.org/content/10.1...
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...
https://www.biorxiv.org/content/10.1101/2025.02.22.639686v1
11 months ago
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