Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System." @xingulab.bsky.social xingulab.dana-farber.org

New work from @xingulab.bsky.social @sshaolab.bsky.social & Elledge lab report structure of Midnolin-proteasome complex & its role in controlling myeloma via ubiquitin-independent degradation. www.cell.com/molecular-ce...

A new study in Molecular Cell led by @danafarber.bsky.social’s Xin Gu, PhD, highlights midnolin as a key regulatory component of proteostasis in plasma cells and suggests that restoring or enhancing this pathway could represent a novel therapeutic avenue in myeloma treatment. bit.ly/4l8Zuwu

So happy and proud to see our story online!! Thank you, the midnolin team!

~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay Come join us for a fun time and invigorating scientific discussions in Vienna! meetings.embo.org/event/25-rna...

👏 Another chapter in the midnolin proteasome story from @xingulab.bsky.social www.biorxiv.org/content/10.1...

Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...