wait, wait, what 😱 Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org www.science.org/doi/10.1126/...

I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

I'm thrilled to announce that I’m opening my own research team in the Department of Genome Biology at I2BC @i2bcparissaclay.bsky.social ! #ATIP-Avenir Very excited to start this new adventure! www.i2bc.paris-saclay.fr/equipe-intra...

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project is collaborating with a broad network of leading wetlabs that test BoltzGen at an unprecedented scale, showing success on many novel targets and pushing the model to its limits!

#JobOffer 💼 Un poste susceptible d’être vacant de Professeur en stabilité des génomes devrait s’ouvrir pour la rentrée 2026 au sein de l’Institut Jacques Monod ➡️ Informations concernant ce poste et la procédure de candidature 🔗 www.ijm.fr/poste-de-pro...

Looks like OpenFold3 has been formally released in a public "preview". Not quite on parity with AlphaFold3 on a few benchmarks shown, in particular for antibody interactions. All info on the github link. I am sure we will hear more about this from the developers github.com/aqlaboratory...

Chemoproteomics v. Boltz-2: "These cases...point to the need to re-train ML co-folding tools on datasets enriched in more diverse types of small molecule-protein interactions...to avoid biased predictions derived from memorization of common orthosteric ligand poses" www.biorxiv.org/content/10.1...

Hot off the press! Our paper, “Global comparative structural analysis of responses to protein phosphorylation”, is now out in Nature Communications! www.nature.com/articles/s41...

Thread on the intellectual landscape around LLMs 👇 I love progress and am happy to see investment in it—but wonder if the amounts currently going into genAI are a missed opportunity to invest in more mundane "data plumbing" and digitalisation. Which could eventually have higher societal benefits.

End-to-end protein design in the browser through evedesign. Generate and interactively explore designs in 2D/3D and export them as codon-optimized DNA. The underlying open source framework (released soon) is build to easily add new methods, more on that soon. 🌐 evedesign.bio

Success rates for Europe’s leading research grants are declining as a surge in applications far outweighs the funds available go.nature.com/479Sni6

Many antiphage systems use NAD+, in many ways. @hugovaysset.bsky.social reviewed them all! Read to know more about all their molecular mechanisms, how phages counteract them, their distribution in bacteria and their conservation in eukaryotic immunity! www.cell.com/molecular-ce...

Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral reverse transcriptases, revealing an unexpected evolutionary origin in bacteria. doi.org/10.1101/2025...

Now published: EnVhogDB, a large database of viral protein family HMM profiles to help functional annotation of new phage genomes - peercommunityjournal.org/articles/10....

Joyeux #anniversaire au CEA qui fête ses 80 ans en 2025🎂 #CEA80ans Je suis fière aujourd’hui d’y participer à une recherche active en sciences du vivant👩‍💻✨ Cette recherche est issue d’un riche lien historique entre énergie atomique ⚛ et biologie 🧬🔬 que je vous invite à (re)découvrir ⬇️

We’re very excited to finally share our latest work: Phyloformer 2, a deep end-to-end phylogenetic reconstruction method: arxiv.org/abs/2510.12976 Using neural posterior estimation, it outperforms Phyloformer 1 and maximum-likelihood methods under simple and complex evolutionary models. 🧵1/17

#CEA80ans | 💙1958 : les Schtroumpfs débarquent dans Spirou et colorent le monde en bleu. À Orsay, le CEA, éclaire l’invisible en utilisant l’atome au service du vivant. ⚛️ Avec la création du SHFJ, il est un acteur historique de la médecine nucléaire. Pour en savoir + 👉 bit.ly/medecine-nuc...

The latest #AlphaFold DB update is out! We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction. Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!

We’re renewing our collaboration with Google DeepMind! We'll keep developing the AlphaFold Database to support protein science worldwide 🎉 To mark the moment we’ve synchronised the database with UniProtKB release 2025_03. www.ebi.ac.uk/about/news/t... 🖥️🧬 #AlphaFold @pdbeurope.bsky.social

👩‍🔬J'ai commencé un kit de démarrage "chercheuses en France" go.bsky.app/TBEzKC #FemmesEnScience J'ai besoin de votre aide pour le remplir et donner de la visibilité aux chercheuses que vous connaissez et qui sont sur Bluesky ! ▶️Taguez celles que vous connaissez, je les ajoute !

We were wondering: Do protein language models learn epistatic signals during pretraining? Turns out, yes! Protein Language Models Capture Structural and Functional Epistasis in a Zero-Shot Setting www.biorxiv.org/content/10.1...

Our second paper with @tcostalab.bsky.social and GoogleDeepMind reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology. www.cell.com/cell/fulltex...

Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n www.biorxiv.org/content/10.1...

Filtering out homologous structures from the PDB at 40% sequence identity is not enough to create a robust test set. Significant leakage persists at this level, and comparative modeling can still produce high quality models.

🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay! 🔬 Study cytoskeletal signaling in collective cell migration 🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France 🗓️ Apply by Aug 22 via the following link: emploi.cnrs.fr/Offres/Docto...

Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions rdcu.be/ezlhg

Finally online: my 1st current opinion article & my 1st article with only 2 authors, small dreams I had since my PhD student years! I hope you enjoy reading it! "Frustration, dynamics, and catalysis" together with my mentor Diego Ferreiro ⭐️ link: t.co/q0K2g61F13

Here's a spicy question for you, pocket friends (because I can't find the answer): how did people determine that Cohesins go *around* the DNA strands to maintain cohesion and not *between* strands? (1/2)

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

In a study of professors, women got 378 new work requests over 4 weeks vs 118 for men. Women spent more time on service, advising & teaching; men on research. Orgs should track who is taking extra duties & ensure they are rewarded and distributed fairly. www.forbes.com/sites/kimels...

Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬 📄 www.biorxiv.org/content/10.1... 🌐 search.foldseek.com/folddisco

We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design! github.com/martinpacesa...

Now two amazing articles in Science (@aaas.org) reveal a new function for integrons--defense against bacterial viruses, also known as phage 7/n

La #ScienceTailleXXelles revient en lle-de-France ! 🤩 Nos 21 nouvelles ambassadrices sont mécatronicienne, archéobotaniste, exobiologiste, ou encore informaticienne👩‍🔬 Chercheuses, doctorantes, ingénieures et techniciennes, toutes ont à cœur de montrer que la science se conjugue aussi au féminin ! ⤵️

[Message de service] N'oubliez pas de voter pour les élections des sections du comité national #CoNRS #CNRS avant le 26 juin #ESR www.dgdr.cnrs.fr/elections/sc... ll n'y avait que ~30% de participation en 2021 alors on vote cette année !!!

New Online! Decoding the interactions and functions of non-coding RNA with artificial intelligence

Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes. 🔗: doi.org/10.1016/j.ce... #Genomics #Evolution #CellBiology #LECA

🚀 Super excited to share our new work, led by @vschnapka.bsky.social bAIes, a Bayesian framework for generating accurate atomic-resolution ensembles of IDPs using #AlphaFold info! Now on @biorxivpreprint.bsky.social → feedback welcome! @pasteur.fr @erc.europa.eu www.biorxiv.org/content/10.1...

The great phage escape: Activating and escaping lactococcal antiphage systems | PNAS https://www.pnas.org/doi/abs/10.1073/pnas.2426508122?af=R

The first year of school is when a maths gap between boys & girls emerges, according to a 4-year longitudinal assessment of language & mathematical performance of all French first and second graders (2,653,082 children!) We now know when to focus interventions 🧪 www.nature.com/articles/s41...

Great news! I’m hiring a PhD student in structural #Bioinformatics to work on modeling protein conformations and interactions at @i2bcparissaclay.bsky.social as part of the ANR SPPICES project! 🚀 📅 Start: 1 Sept 2025 ⏳ Deadline: 23 June 2025 👉Apply now: emploi.cnrs.fr/Offres/Docto...

Planning to apply for #research #funding from the ERC? From the next application rounds, expect changes to the: • proposal structure • evaluation process • extra funding you can request • eligibility for Starting & Consolidator #Grants (from 2027) More 👇 europa.eu/!RPHWvv

Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.

📢Deadline extension until 9 June to register to the PSB Symposium on " #MachineLearning in Cellular #StructuralBiology ", EPN Campus Grenoble, France, 26-27 June 2025🧬 For more information: www.psb-grenoble.eu/psbsymposium... @esrf.fr @embl.org @illneutrons.bsky.social

1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

Pleased to share a new preprint - a great collaboration with @jessicaandreani.bsky.social and the Guerois lab at I2BC, and the Radicella lab at the CEA. Using stuctural modelling, we reveal & validate a 3 protein complex involved in DNA import during transformation. www.biorxiv.org/content/10.1...

🧬PSB Symposium on " #MachineLearning in Cellular #StructuralBiology ", EPN Campus Grenoble, France, 26-27 June 2025🧬 📢Reminder - Call for abstracts (posters & short talks) Submission & registration deadline 25 May: www.psb-grenoble.eu/psbsymposium... @esrf.fr @embl.org @illneutrons.bsky.social

In this evaluation of AlphaFold3 (and other methods), we show that (i) accurate predictions are limited to RNA structures/complexes with structural similarity to PDB and (ii) that current methods are bad at estimating the accuracy of the predictions. www.biorxiv.org/content/10.1...