Chase Morgan
@phagemorgan.bsky.social
๐ค 72
๐ฅ 137
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MD/PhD student. Harm Reductionist. Here for the phages. All views my own.
pinned post!
Trying to be more active here and get away from that toxic other place. If you want to know what I do, check out this paper.
www.pnas.org/doi/10.1073/...
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2321190121
over 1 year ago
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Chase Morgan
Emmanuele Severi
about 1 month ago
#microsky
#phagesky
Jumbo
#phage
PhiKZ
www.nature.com/articles/s41...
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Structural atlas of the intact jumbo phage phiKZ - Nature Communications
Jumbo phages are bacterial viruses with large genomes, oversized icosahedral capsids and complex tail architectures. Here, the authors use cryo-EM to provide a detailed structural analysis of jumbo ph...
https://www.nature.com/articles/s41467-026-71561-2
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Excited to share the last installation of my PhD work. Worked with an all-star team on this one who really made this all come together beautifully.
@ranidreamer.bsky.social
@amardeeep.bsky.social
@benadler.bsky.social
and many others.
www.cell.com/cell-reports...
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The phage nucleus synergizes with an anti-defense protein to resist bacterial immunity
Morgan et al. show that a phage-encoded protein functions as an antitoxin to counter DarTG2-mediated phage defense. They further explore the interplay between this anti-defense protein, the phage nucleus replication compartment, which encloses chimallivirus genomes, and the DarTG2 phage defense system.
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00297-4
about 1 month ago
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Peter Dougherty
5 months ago
Bacteriophages are normally classified as either virulent or temperate. Reality is, of course, more complicated! Here we show many bacterial isolates contain non-temperate phages that can persist through restreaking. Thanks to all co-authors for such a great collaboration!
add a skeleton here at some point
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Samara Reck-Peterson
5 months ago
Join the Reck-Peterson lab in NYC as a HHMI Research Technician! This role will support our new work on the cell biology of secondary metabolite production in filamentous fungi. Apply here:
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
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Research Technician - Reck-Peterson Lab
Primary Work Address: 418 E 71st St #21, New York, NY, 10021 Current HHMI Employees, click here to apply via your Workday account. About the role: The Reck-Peterson lab studies the molecular mechanism...
https://hhmi.wd1.myworkdayjobs.com/en-US/External/job/Research-Technician---Reck-Peterson-Lab_R-4013
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Chase Morgan
Zamin Iqbal
5 months ago
@peterfineran.bsky.social
and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
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Chase Morgan
Jรถrg Vogel
5 months ago
Looking for a POSTDOC to work on jumbo phages (those with large genomes and fascinating cell biology), using our latest ASO technology (Gerovac M et al. 2025 Nature) to define RNA export mechanisms as well as to help to advance phage therapy. Here's the job ad.
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Nucleus-Forming Phages: From Subcellular Organization and ViralโHost Interplay to Prospects for Phage Applications. Some new perspectives on chimalliviruses from our awesome longstanding Thai collaborators (and me).
authors.elsevier.com/c/1mIJB4tPFp...
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https://authors.elsevier.com/c/1mIJB4tPFphMRn
5 months ago
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Jeremy Berg
8 months ago
Powerful and important piece by an outstanding physician, scientist, and human being
@kaminskimed.bsky.social
pdf:
jeremymberg.github.io/jeremyberg.g...
add a skeleton here at some point
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Chase Morgan
Vivek Mutalik
8 months ago
Super cool paper by
@benadler.bsky.social
@erinedoherty.bsky.social
#phage
#phagesky
add a skeleton here at some point
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Chase Morgan
Milan Gerovac
about 1 year ago
CURIOUS ABOUT PHAGE BIOLOGY!? CPIC lab at
@helmholtzhzi.bsky.social
is recruiting in the call +++ CURIOSITY IS INFECTIOUS +++
helmholtz-hzi.de/en/career/jo...
Did you spot the phage? Please share!
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Chase Morgan
Jรถrg Vogel
8 months ago
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today.
nature.com/articles/s4158โฆ
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Chase Morgan
แฏIแTOแ แIแET, แฐแช
10 months ago
Please share my 1 min video on the importance of maintaining NIH funding of infectious diseases and drug discovery research vs rising antibiotic resistance Drastic budget cuts harm our health and imperil the next generation of scientists More @UCSanDiego โBehind Every Breakthroughโ
bit.ly/3FlXQs3
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Chase Morgan
แฏIแTOแ แIแET, แฐแช
11 months ago
Part of the recently completed PhD thesis of outstanding UC San Diego Medical Scientist Training Program student Alex Stream exploring Strep A molecular pathogenesis and vaccinology
journals.asm.org/doi/10.1128/...
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Chase Morgan
Joshua Weitz
11 months ago
Seems like precisely the kind of person that HHS should want giving advice on structural/cell/molecular biology and more. That would require a leadership group that values disciplinary competency and independent expertise.
villalab.ucsd.edu
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This is why I always have to filter my BLAST results. Nice analysis and interesting questions about the persistence of lytic phages in host populations. I suspect for chimalliviruses it's a product of longer latent periods and low infection efficiencies in many hosts.
add a skeleton here at some point
about 1 year ago
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Chase Morgan
Trevor Lithgow
about 1 year ago
"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this โtelocinโ wheedles its way into unsuspecting bacterial neighborsโ
www.science.org/doi/10.1126/...
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Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons
Klebsiella host strains infected with telomere phages can grow to be the dominant lineage in mixed populations.
https://www.science.org/doi/10.1126/sciadv.adt1627
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Chase Morgan
แฏIแTOแ แIแET, แฐแช
about 1 year ago
Pleased to share our new paper out in ๐๐ฐ๐ถ๐ณ๐ฏ๐ข๐ญ ๐ฐ๐ง ๐๐ญ๐ช๐ฏ๐ช๐ค๐ข๐ญ ๐๐ฏ๐ท๐ฆ๐ด๐ต๐ช๐จ๐ข๐ต๐ช๐ฐ๐ฏ led by Monika Kumaraswamy, MD, now Chief of Infectious Diseases UTexas-Tyler Is minimimum inhibitory concentration (MIC) testing the gold standard for antibiotic-resistant superbugs? ๐ฆ ๐งซ ๐งต 1/6
www.jci.org/articles/vie...
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Chase Morgan
Innovative Genomics Institute
about 1 year ago
We teamed up with our pals at
@ucsandiego.bsky.social
to show how jumbo
#phages
โ huge viruses that prey on bacteria โ use sneaky tricks to attack their victims! This knowledge could be used to leverage them as a tool to fight antibiotic resistance. Read more here:
ow.ly/6VLa50Vucc5
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Chase Morgan
Monir Moniruzzaman
about 1 year ago
Our work on cryptic infection of giant viruses was published today in @ScienceMagazine . We discovered a large virus hiding within a green algal genome producing virions. Collaborative effort spearheaded by Virginia Tech, University of Miami & NIOZ scientists.
www.science.org/doi/10.1126/...
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Cryptic infection of a giant virus in a unicellular green alga
Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. Here we describe a 617 kbp integrated giant viral element in the model green alga C...
https://www.science.org/doi/10.1126/science.ads6303
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Interrupting your regularly scheduled doom scrolling for some cool science by my awesome colleagues
www.cell.com/cell-host-mi...
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Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection
The pre-nuclear stage of Chimalliviridae infection and whether the phage nucleus is essential have remained mysterious. Armbruster and Rani etย al. demonstrate that the phage nucleus is required for ph...
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00088-5
about 1 year ago
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Anyone who puts a reddit AMA on their CV should be immediately disqualified from holding a policy position.
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about 1 year ago
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Flashy words like "revolutionize" are thrown around quite liberally in our field. In this case though, I can't think of a more appropriate word. This stuff is ๐ฅ๐ฅ๐ฅ.
add a skeleton here at some point
about 1 year ago
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reposted by
Chase Morgan
แฏIแTOแ แIแET, แฐแช
about 1 year ago
๐๐จ๐ฉ ๐๐๐ฎ๐ฌ๐๐ฌ ๐จ๐ ๐๐๐๐ญ๐ก ๐ข๐ง ๐๐๐ ๐๐๐๐๐ฌ Tuberculosis Dysentery Cholera Malaria Typhoid Pneumonia/Flu Diphtheria Scarlet fever Meningitis Whooping cough ๐๐๐ฃ๐๐ฉ๐๐ฉ๐๐ค๐ฃ/๐๐๐๐๐๐ฃ๐๐จ/๐ผ๐ฃ๐ฉ๐๐๐๐ค๐ฉ๐๐๐จ ๐๐๐๐๐ Heart disease Cancer Accidents COPD Stroke Alzheimerโs Diabetes Pneumonia/Flu Kidney disease Suicide
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When I started my PhD, we knew exactly zero about the phage nucleus protein import pathway. Out today in Nature, parallel work by Claire Kokontis picking apart this pathway. PicA vs. Imp1, let the games begin.
www.nature.com/articles/s41...
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Multi-interface licensing of protein import into a phage nucleus - Nature
This study uncovers a highly conserved jumbo phage protein, Imp1, that possesses multiple interfaces to license protein import into a proteinaceous nucleus-like compartment, using a genetic selection ...
https://www.nature.com/articles/s41586-024-08547-x
over 1 year ago
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Chase Morgan
แฏIแTOแ แIแET, แฐแช
over 1 year ago
Amazing story of a young cancer patient's resilience, a scary infection with MDR ๐๐ด๐ฆ๐ถ๐ฅ๐ฐ๐ฎ๐ฐ๐ฏ๐ข๐ด ๐ข๐ฆ๐ณ๐ถ๐จ๐ช๐ฏ๐ฐ๐ด๐ข expressing NDM-1, and successful application of phage therapy Care coordinated by Peds ID specialist and UCI Asst Prof Chulie Ulloa, MDโfriend and former PSDP, K08, and UCPPFP mentee in the lab
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Compassionate-use therapies for a deadly infection save the life of cancer patient - CHOC Pediatrica
CHOC infectious disease expert Dr. Erlinda โChulieโ Ulloa makes history nationally with investigational medication.
https://care.choc.org/compassionate-use-therapies-for-a-deadly-infection-save-the-life-of-cancer-patient/
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Me: If this experiment works the first time, I'm throwing a party. Experiment: Did somebody say party?
over 1 year ago
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Chase Morgan
Kim Cooper
over 1 year ago
I prefer shameful self-promotion by re-posting, but Pew and UCSD Biosciences have not migrated to this new utopia, so... Exciting news! I get to play with one of my besties
@thevillalab.bsky.social
today.ucsd.edu/story/kimber...
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Kimberly Cooper and Elizabeth Villa Named Pew Innovation Fund Investigators
UC San Diego School of Biological Sciences Professors Kimberly Cooper and Elizabeth Villa have been selected by the Pew Charitable Trusts as members of its 2024 class of Innovation Fund Investigators.
https://today.ucsd.edu/story/kimberly-cooper-and-elizabeth-villa-named-pew-innovation-fund-investigators
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Chase Morgan
Ben Engel
almost 4 years ago
Excited to share our new study with the Mรผller and @SchullerJm labs, online @nature:
https://www.nature.com/articles/s41586-022-04971-z
This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store
#CO2
. How does it do it?
#CryoET
revealed membrane-anchored bundles of...
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Chase Morgan
bioRxiv Biochemistry
over 1 year ago
Structural diversity and oligomerization of bacterial ubiquitin-like proteins https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1
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Structural diversity and oligomerization of bacterial ubiquitin-like proteins https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1
Bacteria possess a variety of operons with homology to eukaryotic ubiquitination pathways that encod
https://www.biorxiv.org/content/10.1101/2024.11.21.623966v1
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Trying to be more active here and get away from that toxic other place. If you want to know what I do, check out this paper.
www.pnas.org/doi/10.1073/...
loading . . .
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2321190121
over 1 year ago
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