Milan Gerovac
@gerovac.bsky.social
📤 119
📥 84
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pinned post!
No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social
@helmholtz-hiri.bsky.social
@uni-wuerzburg.de
@helmholtzhzi.bsky.social
published now in
@nature.com
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Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...
https://www.nature.com/articles/s41586-025-09499-6
12 days ago
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reposted by
Milan Gerovac
Martial Marbouty
4 days ago
You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range.
@rkoszul.bsky.social
@natmicrobiol.nature.com
@cnrs.fr
@institutpasteur.bsky.social
www.nature.com/articles/s41...
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Phages with a broad host range are common across ecosystems - Nature Microbiology
Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
https://www.nature.com/articles/s41564-025-02108-2
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reposted by
Milan Gerovac
Helmholtz Institute Würzburg
5 days ago
Recent study in
@natbiotech.nature.com
: A team led by
#HIRI’s
Beisel lab introduced a new way to fine-tune genetic material. They describe an innovative technique where chemical tags are attached directly to DNA, opening new possibilities in medicine, agriculture, and biotechnology. ➡️
rdcu.be/eG4fk
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Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes
Nature Biotechnology - Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.
https://rdcu.be/eG4fk
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No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social
@helmholtz-hiri.bsky.social
@uni-wuerzburg.de
@helmholtzhzi.bsky.social
published now in
@nature.com
loading . . .
Programmable antisense oligomers for phage functional genomics - Nature
Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...
https://www.nature.com/articles/s41586-025-09499-6
12 days ago
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reposted by
Milan Gerovac
Helmholtz-Zentrum für Infektionsforschung (HZI)
20 days ago
Es war uns eine große Ehre, Yasmine Belkaid, Präsidentin des
@pasteur.fr
, heute am HZI begrüßen zu dürfen. Vielen Dank für die wertvollen wissenschaftlichen Diskussionen und den inspirierenden Vortrag über die Immunität gegenüber der Mikrobiota und die Auswirkungen auf die Impfstoffentwicklung.
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reposted by
Milan Gerovac
Helmholtz-Zentrum für Infektionsforschung (HZI)
6 months ago
RNA-basierte Medizin hat das Potenzial viele Krankheiten zu heilen. Am
@helmholtz-hiri.bsky.social
arbeiten Forscher:innen unter anderem an programmierbaren
#Antibiotika
und diagnostischen Werkzeugen auf RNA-Basis. Mehr dazu findet ihr in unserem Wissensportal.
www.helmholtz-hzi.de/wissen/wisse...
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HZI-Wissensportal: RNA-Biologie
RNA-Forschung eröffnet ein breites Spektrum an Möglichkeiten für Therapeutika und Diagnosemethoden und hat das Potenzial viele Krankheiten zu heilen.
https://www.helmholtz-hzi.de/wissen/wissensportal/rna-biologie/
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reposted by
Milan Gerovac
Jörg Vogel
6 months ago
If you want to do single-cell RNA-seq on your favourite bacterium, here‘s our detailed Nature Protocol for microbial MATQ-seq. It profiles up to 600 genes in a single bacterial cell!
www.nature.com/articles/s41...
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Transcriptomic profiling of individual bacteria by MATQ-seq - Nature Protocols
Bacterial single-cell sequencing via MATQ-seq combines index sorting, random priming and rRNA depletion, and offers high cell retention and transcript capture rates, making it ideal for experiments wi...
https://www.nature.com/articles/s41596-025-01157-5
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reposted by
Milan Gerovac
Aude Bernheim
6 months ago
The EMBO workshop on the Immune System of Bacteria just started in sunny Paris in the Institut Pasteur. So excited for three days of awesome science.
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reposted by
Milan Gerovac
bioRxiv Microbiology
6 months ago
Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity
https://www.biorxiv.org/content/10.1101/2025.04.06.647259v1
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reposted by
Milan Gerovac
Helmholtz-Zentrum für Infektionsforschung (HZI)
6 months ago
„Gesunde Anfänge, hoffnungsvolle Zukunft“ ist Thema des
#Weltgesundheitstags
@who.int
, der die Gesundheit von Müttern & Neugeborenen fokussiert. Auch wir am HZI arbeiten auf diesem Gebiet. So erforscht
@ntorow.bsky.social
bspw. das frühkindliche Immunsystem.
www.helmholtz-hzi.de/media-center...
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reposted by
Milan Gerovac
Helmholtz-Zentrum für Infektionsforschung (HZI)
6 months ago
🔬The application deadline in our program "CURIOSITY IS INFECTIOUS" is less than a month away! 👉 Apply by April 20 for one of 16 exciting PhD projects - from host-pathogen interactions and novel antiinfectives to molecular mechanisms of infection and immunity.
www.helmholtz-hzi.de/en/career/jo...
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reposted by
Milan Gerovac
Helmholtz-Zentrum für Infektionsforschung (HZI)
6 months ago
#Lungenentzündungen
mit Staph. aureus zählen zu den gefährlichsten Infektionen, die im Krankenhaus auftreten können. Eine Forschungsgruppe unter Leitung des HZI hat nun einen neuen Wirkstoffkandidaten gegen Lungeninfektionen durch den Krankenhauskeim entdeckt.
www.helmholtz-hzi.de/media-center...
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Neuer Wirkstoff hemmt Staphylococcus aureus-Toxin
Helmholtz-Zentrum für Infektionsforschung entwickelt innovative Wirkstoffklasse zur Hemmung von Krankenhauskeimen
https://www.helmholtz-hzi.de/media-center/newsroom/news-detailseite/neuer-wirkstoff-hemmt-staphylococcus-aureus-toxin-hoffnungstraeger-bei-lungenentzuendungen/
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CURIOUS ABOUT PHAGE BIOLOGY!? CPIC lab at
@helmholtzhzi.bsky.social
is recruiting in the call +++ CURIOSITY IS INFECTIOUS +++
helmholtz-hzi.de/en/career/jo...
Did you spot the phage? Please share!
6 months ago
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reposted by
Milan Gerovac
Helmholtz-Zentrum für Infektionsforschung (HZI)
7 months ago
🔬 "CURIOSITY IS INFECTIOUS" – PhD Positions in Infection Research at HZI! We are looking for the next generation of pioneers in infection research! 🧬🦠💊 Explore exciting projects - from host-pathogen interactions and novel antiinfectives to molecular mechanisms of infection and immunity.
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Join our team as a doctoral researcher, impact science and go viral. We illuminate protein-RNA complexes at the interface between phages and bacterial pathogens
@helmholtzhzi.bsky.social
www.helmholtz-hzi.de/en/career/jo...
8 months ago
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reposted by
Milan Gerovac
Aude Bernheim
9 months ago
What is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret.
www.biorxiv.org/content/10.1...
Interactive UMAP to have fun
mdmparis.github.io/antiphage-la...
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