@oscarpuiggene.bsky.social
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reposted by
6 months ago
Interested in engineering bacteria to turn
#C1feedstocks
into high-value chemicals for
#bioproduction
? Here is a thread summarizing our latest review on the roadblocks and how we might bio-hack our way past them 🧵 1/n
academic.oup.com/femsre/advan...
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Seven Critical Challenges in Synthetic One-Carbon Assimilation and Their Potential Solutions
Abstract. Synthetic C1 assimilation holds the promise of facilitating carbon capture while mitigating greenhouse gas emissions, yet practical implementatio
https://academic.oup.com/femsre/advance-article/doi/10.1093/femsre/fuaf011/8104276
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reposted by
7 months ago
..and fine tuning between endogenous activities and novel functions implemented by
#metabolicengineering
. A story - now available in preprint - brilliantly led by our Oscar! 💪
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reposted by
7 months ago
The utilization of
#C1-feedstocks
, such as methanol, by non-model bacteria demands an in-depth analysis of design alternatives, a modular strategy to identify bottlenecks and efficient solutions within the host
#metabolism
of the chosen host...
www.biorxiv.org/content/10.1...
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Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation
The urgent need for a circular carbon economy has driven research into sustainable substrates, including one-carbon (C1) compounds. The non-pathogenic soil bacterium Pseudomonas putida is a promising ...
https://www.biorxiv.org/content/10.1101/2025.02.17.638773v1
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reposted by
Pablo Ivan Nikel
8 months ago
Preprint alert🚨Systematic
#engineering
of synthetic serine cycles in
#Pseudomonas
putida uncovers emergent topologies for
#methanol
assimilation ·
@biorxivpreprint.bsky.social
led by Òscar Puiggené
#SynBio
#Methylotrophy
#CircularEconomy
www.biorxiv.org/content/10.1...
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