Holy smoke. What ultimately happened???

This expands our knowledge of tau filaments from frontotemporal dementia and parkinsonism linked to chromosome 17. Because these mutations drive the formation of the Pick fold, they may also be useful in the development of model systems for Pick's disease in cells or animals.

We report the Pick fold and 2 variants thereof for tau filaments from individuals with MAPT mutations encoding for D252V, G272V, S320F and Delta_G389-I39, and we use these to reconstitute the Pick fold with recombinant tau in vitro. By @qcxy8886.bsky.social. 🥳 www.biorxiv.org/content/10.6...

Measles doesn’t always end when the rash fades. For one woman, it returned 25 years later — as a fatal brain disease. SSPE affects 1 in 50,000 measles cases. There’s no cure. There is prevention. This story will stay with you. ⬇️ www.independent.co.uk/news/health/...

The amyloid packing difference (APD) is a new metric to compare amyloid structures. Analysis of disease-specific structures provides context for the interpretation of APDs for new comparisons. I hope it will be useful! 🤗 www.biorxiv.org/content/10.6...

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

Star student & postdoc Kiarash Jamali is setting up his own group at the Ellison institute in Oxford. Join him for the most exciting machine learning research in structural biology and beyond!! 🤩 #ProudPI

I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉 www.jbc.org/article/S002...

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead! #OpenSoftwareAcceleratesScience www.biorxiv.org/content/10.1...

The best cover🥰, paired cats & paired helical filaments.

Finally, the paper by @qcxy8886.bsky.social on #cryoEM of tau mutants V337M and R406W is out in NSMB (which is not the fastest journal). Tau filaments with these mutations have the same structures as in AD, which may be useful for the development of faster models. www.nature.com/articles/s41...

At the #Synuclein2025 in Cambridge this week. There is a large unmet need for help with #cryoEM structure determination of amyloids.

“If you’re really curious about science, then you should do it.” We recently caught up with David Barford, Group Leader in the LMB’s Structural Studies Division, to learn more about his career, what inspires him and his group’s research into kinetochore complexes. youtu.be/qaudt961iMU

I found the below in the stand of @stressmarq.bsky.social at #ADPD2025. When I asked how these "tau oligomers" were made, I was told this was a company secret! 😱😱😱 How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?

Alzforum has written a piece on our most recent updates to the structure-based classification of tauopathies. 🥳 www.alzforum.org/news/researc...

Happy to share our latest publication on @naturesmb.bsky.social Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W. thanks @sjorsscheres.bsky.social and Michel Goedert's support. 🥳 rdcu.be/edqzW rdcu.be/edoGv