Models for the architecture of the human inner kinetochore on centromeric α-satellite CENP-A nucleosome arrays pubmed.ncbi.nlm.nih.gov/42120391/ #cryoem

The Norwich Cambridge Science Symposium is back this summer! Save the date (13th-14th August). Check out our updated website : nocass.org, and follow @nocassofficial.bsky.social for upcoming updates on keynote speakers, panelists and workshops! (Registration opens 1st June).

Assembly and phospho-regulatory mechanisms of the budding yeast outer #kinetochore KMN complex. New study from Noah N. Turner (@noahnturner.bsky.social), David Barford and colleagues @mrclmb.ac.uk: rupress.org/jcb/article/... #CellDivision #StructuralBiology #kinetochores #centromeres #cryoEM

@noahnturner.bsky.social, Barford et al reveal conserved underlying mechanisms of complex assembly, auto-inhibition, & phosphoregulation that ensure precise control of KMN assembly onto #centromeres to enable genome division. rupress.org/jcb/article/... #kinetochores #cryoEM #biochemistry #genetics

Happy to see our paper describing cryo-EM structures of the budding yeast KMN kinetochore complex published in @jcb.org! Our structure reveals how an important hub mediates and regulates assembly of the machine that segregates chromosomes. #cryo-EM @mrclmb.ac.uk 🔗 rupress.org/jcb/article/...