I love acetazolamide!

1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:

After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk jamanetwork.com/journals/jam...

Mandatory #KidneyWk gathering with my fellow Channeleers from Channel Your Enthusiasm podcast 🎙️ www.rosebook.club @kidneyboy.bsky.social @amyaimei.bsky.social @annagaddy.bsky.social @jwaitz.bsky.social

A great talk on hyponatremia! As a fellow “channeleer”, was so happy to meet Amy Yau! I learned about risk factors for over-correction and ODS and mechanisms of cerebral edema and demyelination. #channelyourenthusiasm @kidneyboy.bsky.social @amyaimei.bsky.social @asnkidney.bsky.social #kidneywk

@sophia-kidney.bsky.social got shoved into a corner by ASN but well worth the trek to check out her poster and try out abcKidney #kidneywk

Visit our OSU posters and see all the cool things we’re doing and seeing! 28, 89, 841, 902!

Nice of @ajkd.bsky.social to recognize this! Congrats to @karenwoomd.bsky.social @nephcrit.bsky.social @amyaimei.bsky.social and all the others! ajkdblog.org/2025/11/06/2... #NephSky #KidneyWk

Loving the #StarWars theme! Yes we can… cure kidney disease, presentation by Vlado Perkovic 4 pillars of CKD mgmt ✅ RAASi ✅ SGLT2i ✅ MRA ✅ GLP1rA #KidneyWk

We have a new therapy for type 1 diabetes! FINE-ONE with significant proteinuria reduction compared to placebo on a background of RASi with an acceptable safety profile. Where’s the simultaneous pub?? Sglt2 inhibitors are next…#kidneywk

The BICAR-ICU-2 trial just dropped! RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia VERY similar conclusions to BICAR-ICU-1 🧵 #1/ jamanetwork.com/journals/jam... #EMIMCC

Listen to the latest episode of the Burton Rose Book Club @juancarlosqvelez.bsky.social #cigarshaped CaOx crystals for ethylene glycol toxicity (not classic envelope shaped) #pearlsbyJCV www.nejm.org/doi/full/10....

Caveat: some meds are designed with certain pharmacokinetic goals in mind. Aminoglycosides, for example generally work better with higher peak concentrations, so splitting the dose up is counterproductive despite achieving a smoother concentration

Core Curriculum by Kristen Tillquist et al. The Nephrologist’s Perspective in Evaluation and Management of Localized Renal Masses bit.ly/4o6z0NG #OpenAccess

Diagnosis and Management of Osteoporosis in Advanced Kidney Disease: A Review ca. 2022 from @ajkd.bsky.social #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/34419519/

In Lupus nephritis patients, neutrophils have increased surface LAMP1, which is externalized after activation. Soluble LAMP1 is increased both in the blood and urine of patients, correlating with histological activity. #NephSky 🧪 Our paper in @eurjimmunol.bsky.social doi.org/10.1002/eji....

Quick Guide to Converting ESAs ca. 2023 from @amyaimei.bsky.social #Nephpearls #NephSky 👉🏼 www.renalfellow.org/2023/05/02/q...

How are you investing in those you lead? Make it a leadership habit. Episode 7: Leadership Hack - Investing in Others (feat. Joshua Hartzell, MD) open.substack.com/pub/onleadin... @bradcutrellmd.bsky.social @rsternszus.bsky.social @ovinimd.bsky.social @gbosslet.bsky.social

1/ Even outside of AVS the intra-individual variability of plasma aldo is important. Another study with the same message. www.ahajournals.org/doi/10.1161/...

Cadmium??!! Very cool case.

Primary Prevention for Burnout Ten Principles to Advance Occupational Well-being in Health Care Organizations - Mayo Clinic Proceedings www.mayoclinicproceedings.org/article/S002... @bradcutrellmd.bsky.social @rsternszus.bsky.social @amyaimei.bsky.social

Pool listening... www.podbean.com/ep/pb-4jca9-... @vipsmdmed.bsky.social @bradcutrellmd.bsky.social @amyaimei.bsky.social @rwc90.bsky.social @impocus.bsky.social @rsternszus.bsky.social

📣 The call for Late-Breaking Clinical Trials is open for ASN #KidneyWk 2025! Submit Phase 2, 3, or 4 clinical trials to present this November in Houston and reach 12,000+ kidney health professionals. 🗓️ Deadline: Tuesday, September 9, at 2:00 p.m. EDT 🔗 asn.kdny.info/Kbvo50WqwvO

Yes you should be able to reduce medications after adding Spironolactone. I withdraw based on other adverse med effects (edema = CCB; K = thiazide/RAASi) I use this figure in my talks on Resistant HTN...(observational, but holds up imo) pubmed.ncbi.nlm.nih.gov/11991219/

Reed Tuckson, MD delivered an outstanding plenary session yesterday at #IM2025 Physicians need to embrace their roots of caring as #leaders. While this is obvious for patient care, we need to use that same inspiration of caring when leading. www.amazon.com/dp/B0DSQ41THX/

Dr Hartzell is the GOAT when it comes to leadership in medicine. Leadership is a skill we can nurture and cultivate… just because you are a physician doesn’t make a leader. A leader is so much more

Physiologically it never made sense to fluid restrict HF patients without hyponatremia. No difference in outcomes in 👇study, which was predictable. At the same time - from a study perspective - the actual difference in fluid intake between groups was <300cc/day. pubmed.ncbi.nlm.nih.gov/40159556/

This looks like a great line up this year!

Does your nephrology program have a #bootcamp? If so, what key topics are discussed? Looking to revamp ours!

Announcing the #NephJC internship, @nephjc.bsky.social and @kireports.bsky.social joining forces www.nephjc.com/intern-app for details and to apply! #NephSky

One more piece to the anti-nephrin autoantibodies story #nephroticsyndrome #raredisease #glomerulardisease #Nephsky @kidneyint.bsky.social @isgd.bsky.social

Comments due today, March 6th. #nephsky #medsky #hypertension

📢 March is #NationalKidneyMonth! #SockItToKidneyDisease and take on the #850Challenge to raise awareness for the 850 million living with kidney diseases. Challenge yourself to 8,500 steps, 8.5 miles, or 8.5 minutes of activity. Share and tag @asnkidney.bsky.social !

It turns out, that under the right conditions, carbonyl groups form on MPO. Hydralazine actually ATTACHES to these carbonyl groups, probably modifying the MPO conformation and inducing a neo-antigen, which eventually causes the formation of anti-MPO IgM!

Exciting work from the UNC Kidney Center this week: pubmed.ncbi.nlm.nih.gov/40020049/. Posting because we don't have an official account here (yet), but some excellent folks in our lab discovered important steps in the mechanism by which hydrANCAzine causes...well.. ANCA! #NephSky #MedSky 🧵

I got a link to the new Endocrine Society guideline for primary aldosteronism (draft open for public comments). www.surveymonkey.com/r/endopacpg >Suggests screening all individuals with hypertension >Proposes various strategies re: handling of confounding BP meds during testing #NephJC #Nephsky

Spicy! Adding lasix to the management of hepatorenal syndrome might be ok if you bump the MAP with pressors @juancarlosqvelez.bsky.social doi.org/10.1016/j.ek... #nephsky #liversky

OK tell me for real...how many of you are using urinary NGAL routinely and how has it helped you?

Help support care packages for our dialysis community. The @NKFCentralOH will be creating them on March 25 and could use your support for supplies! Any little bit helps! #ohiokidneyhealth #kidneyhealth #ohiodialysis #dialysis support.kidney.org/campaign/202...

NEW on the #AJKDBlog: Timothy Yau interviews Anna Gaddy, @amyaimei.bsky.social , and Murugapandian about the rapidly changing landscape of viral nephropathies:

For HTN, starting a 2-pill low-dose Rx was noninferior to stepped monotherapy. 2-pill & 3-pill low-dose strategies were not superior to stepped monotherapy #CardioSky #MedSky jamanetwork.com/journals/jam... @jama.com @anastasiasmihaili.bsky.social @vietheartpa.bsky.social @psatishmd.bsky.social

Core Curriculum by @amyaimei.bsky.social, Sangeetha Murugapandian, Ali W. Rizvi, and Anna Gaddy: Viral Nephropathies: Core Curriculum 2024 https://bit.ly/413soY9 (FREE)

What's the highest renin you've ever seen? An extreme example of a common issue. Severe hyperreninemia secondary to combination ARB+thiazide. www.ccjm.org/content/91/2... (free) @amyaimei.bsky.social #medsky #nephsky

Important new data from CREDENCE: Oral loop diuretic intensification (ODI) in diabetes & CKD: - Is frequent (1 in 7 patients) - Associated with 30x increased risk of subsequent HF - Is reduced with SGLT2i by 40% Led by Safia Chatur, open access in #EJHF onlinelibrary.wiley.com/doi/10.1002/...

How We Treat ANCA-Associated #Vasculitis: A Focus on the Maintenance Therapy #nephsky www.mdpi.com/2077-0383/14...

Any graduating fellows or faculty interested in moving to the Midwest??!!! Namely The Ohio State University??!!!

1/ Have you ever wondered why advanced renal disease often leads to often debilitating pruritis? Why would kidney failure lead someone to itch uncontrollably? #tweetorial

The Aldosterone Paradox: A Skeetutorial:

Counting down the Top Ten #AJKDBlog posts of 2024: AJKDBlog Interviews Editor @maximalchange.bsky.social chats with Juan-Jesús Carrero and Edouard Fu about their recent study: 8️⃣ Cystatin-C and Cr-Based eGFRs: What Differences Does the Difference Make? https://bit.ly/3Dq5FM9 (FREE)