Today is #C3GAwarenessDay! At ISGD, we stand with people living with this rare kidney disease. As a medical society for #GlomerularDisease experts, we're committed to raising awareness and moving the science forward to bring more hope and solutions to the C3G community. #C3G #ISGD

This is so shameful…

Fresh online on @natcomms.nature.com ! Great collaboration with the lead team at GharaviLab / CPMG. Large exome-wide analysis that points to many findings, including two novel genes: ARID3A and NR6A1. #CAKUT #humangenetics #development #pediatrics #NephSky #SkyNeph www.nature.com/articles/s41...

Wow! Second approved drug for an ultrarare disease in a few months, and with broader indication. What a milestone! Time for EMA’s approval now. #raredisease #glomerulardisease #c3g #nephSky

Very remarkable long-term outcomes and safety profile for one of the first mAbs ever used in glomerular diseases #glomerulardiseases #rarediseases #nephSky

To do or not to do—genetic testing for autosomal dominant polycystic kidney disease in children and adolescents doi.org/10.1016/j.kint.2025.05.001 Original article: doi.org/10.1016/j.kint.2025.02.026 #KICommentary #NephSky #MedSky #ADPKD

Today’s Daily Cartoon, by Paul Noth. #NewYorkerCartoons Sign up for our humor newsletter to never miss a Daily Cartoon: nyer.cm/kyxchAh

President Trump claims the US strike on Iran was a "spectacular military success." We'll see. What we do know is that Trump has pushed the US into a new war in the Middle East with considerable risks of escalation. Here are the risks I'm concerned about: www.nytimes.com/2025/06/22/o...

Kidney health finally prioritized in the WHO noncommunicable disease agenda! #kidneyhealthmatters #nephsky #medsky

In a new publication, Drs. Steers, Gharavi and colleagues performed genetic and immunological studies of IgA nephropathy and demonstrated a new role of aberrant O-glycosylation in the pathogenesis of IgA Nephropathy. Read more here: www.jci.org/articles/vie...

Increased risk of developing #kidneydisease in offspring exposed to maternal preeclampsia independently from preterm birth? #nephsky #medsky

Scientific progress grows out of freedom. As a society, we must stand with scientists and speak out against restrictions on scientific freedom and funding - we are all in this together. www.nature.com/articles/d41... www.science.org/content/arti...

Alternative complement pathway dysregulation in CKD and CKD progression, endothelial inflammation and cardiovascular outcomes… room for complement inhibitors beyond complement-mediated kidney diseases? www.jci.org/articles/vie... #NephSky #MedSky

Hey I know these people! Check out this paper👇

After Trump’s first 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding.

100-day mark and 1361 to go… www.nytimes.com/interactive/...

Public health, biomedical science, and the well being of Americans will be worse off for this week's devastating cuts at HHS. My latest for @opinion.bloomberg.com (gift link):

"The strategy of not speaking up out of fear is not working" @lisamjarvis.bsky.social calls Big pharma to mobilize and support federally funded research and drug evaluation - both engines of most innovation biotech and pharma companies develop.

Finally, top scientists speak up against the Trump administration in a letter signed by 2,000 elected members of the National Academies of Sciences, Engineering, and Medicine: "the nation's scientific enterprise is being decimated"; see related NYT coverage here: www.nytimes.com/2025/03/31/s...

Beautiful, mechanistic work! Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy www.jci.org/articles/vie...

Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model. www.sciencedirect.com/science/arti...

Columbia's "IgA Nephropathy Diagnosis & Treatment Updates 2025" on April 4th. All the latest IgAN updates in one place with outstanding speakers! @cuimcglomcenter.bsky.social @cuimcmedicinedept.bsky.social @jradnephro.bsky.social @kirylukk.bsky.social #Nephsky #glomerulardisease

NEW editorial on what public health means under Trump 2.0 At The Lancet Public Health, it still means to stand for the communities we serve, to report, document, support researchers and practitioners, and advocate for better health for ALL. Read #openaccess www.thelancet.com/journals/lan...

What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy #MedSky

How collection of broad family history from CKD patients improve clinical risk stratification. Proud to be part of this. Thanks to Francesca Zanoni, @kirylukk.bsky.social #CureGN #CRIC #NephSky

Nice to see this in print - combined analysis of #CureGN and #CRIC demonstrates the value of broad family history collection from patients with various forms of CKD. Interestingly, positive family history of diabetes was associated with a higher risk of CKD progression even in non-diabetics!

Emerging role of genetics🧬 in #kidneytransplantation doi.org/10.1016/j.kint.2024.09.026 #KIMiniReview #ChronicKidneyDisease #CKD #genetickidneydisease #NephSky #MedSky

Combined PLA2R-Ab testing with ELISA and IIF provided optimal test characteristics in making a non-invasive diagnosis of MN before or soon after kidney biopsy. Further studies needed to assess whether genetic data can augment this approach. bit.ly/CJASN0671 #ASNCJASN @jarcyzphd.bsky.social

#WorldKidneyDay reminds of the vital role kidneys play in health #KidneyDisease affects 850+ million people worldwide >70% undiagnosed and untreated #kidneyhealth is a global health priority #EarlyDetection =early protection #CKDAwareness #NephSky #MedSky #AreYourKidneysOK @thelancet.bsky.social

Wondering how they pick which grants to cut… “banned” words maybe?

One more piece to the anti-nephrin autoantibodies story #nephroticsyndrome #raredisease #glomerulardisease #Nephsky @kidneyint.bsky.social @isgd.bsky.social

Globally, 150+ rare kidney diseases affect 60–80 people per 100,000. Many are hereditary, with inherited kidney disease seen in 10% of adults & most children on #KRT. Yet, barriers to diagnosis & treatment persist, especially in LMICs. On #RareDiseaseDay, we call for action! #KidneyHealthMatters

Totally agree with @kirylukk.bsky.social

Great minds… within 24 hrs both us at @nature.com and @science.org make similar appeals to the research community. And @holdenthorp.bsky.social and I didn’t even exchange notes about it ;-) 🧪 www.nature.com/articles/d41... www.science.org/doi/10.1126/...

"These [NIH indirect cost reimbursement] cuts should be a rallying cry for higher education to come together to make the case for the American system of research and teaching,” writes @holdenthorp.bsky.social in a new #ScienceEditorial. scim.ag/4b2nv4D