Cravedi Lab
@cravedilab.bsky.social
š¤ 163
š„ 184
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Kidney & Immunology Research at Icahn School of Medicine at Mount Sinai
Beyond traditional roles: vitamin D and erythropoietin as immune modulators in kidney diseases
academic.oup.com/ckj/article/...
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Beyond traditional roles: vitamin D and erythropoietin as immune modulators in kidney diseases
ABSTRACT. Vitamin D and erythropoietin (EPO) are kidney-derived hormones classically known for their roles in mineral metabolism and erythropoiesis, respec
https://academic.oup.com/ckj/article/19/5/sfag120/8664054
2 days ago
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The Impact of Initial Kidney Graft Function on Long-term Outcomes: A Matter of Definition?
journals.lww.com/transplantjo...
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The Impact of Initial Kidney Graft Function on Long-term... : Transplantation
An abstract is unavailable.
https://journals.lww.com/transplantjournal/fulltext/9900/the_impact_of_initial_kidney_graft_function_on.1347.aspx
9 days ago
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www.fda.gov/drugs/drug-a...
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CDER proposes to withdraw approval of TAVNEOS
CDER proposes to withdraw approval of TAVNEOS
https://www.fda.gov/drugs/drug-alerts-and-statements/cder-proposes-withdraw-approval-tavneos
11 days ago
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CKD remission and even regression: a vision reaffirmed
www.sciencedirect.com/science/arti...
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CKD remission and even regression: a vision reaffirmed
https://www.sciencedirect.com/science/article/pii/S0085253826001389?via%3Dihub
23 days ago
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Mechanisms and Treatment of Immune Complex GN and C3 GN
www.youtube.com/watch?v=yZtL...
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Mechanisms and Treatment of Immune Complex GN and C3 GN
YouTube video by American Society of Transplantation
https://www.youtube.com/watch?v=yZtLzK5Oji4
24 days ago
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B-cell-targeting therapies in podocytopathies
link.springer.com/article/10.1...
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B-cell-targeting therapies in podocytopathies - Pediatric Nephrology
Podocytopathies, including minimal change disease and focal segmental glomerulosclerosis, represent the leading causes of nephrotic syndrome in children and adolescents. Although traditionally conside...
https://link.springer.com/article/10.1007/s00467-026-07297-4
27 days ago
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āScience needs defendingā: record number of researchers run for office in US mid-terms
www.nature.com/articles/d41...
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āScience needs defendingā: record number of researchers run for office in US mid-terms
Many Democrats making the switch to politics are motivated by the Trump administrationās cuts to science ā whereas energy and AI are a pull for some Republicans.
https://www.nature.com/articles/d41586-026-01134-2
30 days ago
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reposted by
Cravedi Lab
Oded Rechavi
about 1 month ago
BTW there's now a prize:
coller-dolittle-24.sites.tau.ac.il
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Home | Coller dolittle 24
https://coller-dolittle-24.sites.tau.ac.il/
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Dual Anti-CD20/Anti-CD38 Therapy for Severe Recurrent FSGS with Longitudinal Anti-Nephrin Assessment url:
academic.oup.com/ndt/article/...
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Dual Anti-CD20/Anti-CD38 Therapy for Severe Recurrent FSGS with Longitudinal Anti-Nephrin Assessment
Xhuliana Kajana, Agnese Spennacchio, Francesca Chiara Viazzi, Carolina Bigatti, Pasquale Esposito, Angelica Parodi, Gianluca Caridi, Daniela Picciotto, Mar
https://academic.oup.com/ndt/article/doi/10.1093/ndt/gfag088/8654252
about 1 month ago
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Autosomal dominant polycystic kidney disease - The Lancet
www.thelancet.com/journals/lan...
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Autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease, resulting in substantial morbidity and mortality globally. Advances in molecular geneti...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2900046-2/fulltext
about 2 months ago
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Iptacopan in IgA Nephropathy ā Final 24-Month Data
www.nejm.org/doi/full/10....
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Iptacopan in IgA Nephropathy ā Final 24-Month Data | NEJM
Overactivation of the alternative complement pathway contributes to IgA nephropathy and glomerular inflammation. In the 9-month interim analysis of this phase 3 trial, iptacopan, a complement facto...
https://www.nejm.org/doi/full/10.1056/NEJMoa2600743?query=featured_home
about 2 months ago
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Preclinical and clinical studies on kidney allograft tolerance via hematopoietic chimerism - American Journal of Transplantation
www.amjtransplant.org/article/S160...
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Preclinical and clinical studies on kidney allograft tolerance via hematopoietic chimerism
In current clinical practice, successful kidney transplantation requires lifelong immunosuppression to prevent graft rejection, which is unfortunately associated with significant morbidity, mortality,...
https://www.amjtransplant.org/article/S1600-6135%2826%2900137-1/fulltext
about 2 months ago
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Updates on Kiney Transplant
www.instagram.com/reel/DV1AP8r...
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Instagram
Create an account or log in to Instagram - Share what you're into with the people who get you.
https://www.instagram.com/reel/DV1AP8rlOSO/
about 2 months ago
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Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+Ī²7+ cells in IgA nephropathy
www.kidney-international.org/article/S008...
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Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+Ī²7+ cells in IgA nephropathy
Galactose-deficient IgA1 (Gd-IgA1) plays a key role in IgA nephropathy (IgAN), but the location of the plasma cells responsible for its production remain unknown.
https://www.kidney-international.org/article/S0085-2538%2826%2900010-4/fulltext
about 2 months ago
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www.nytimes.com/video/world/...
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Video: Humpback Whale Stranded Off German Coast Is Freed by Rescuers
In a last-ditch effort, rescuers were at last able to free a 40-foot humpback whale that had been stuck in shallow waters near the coast of Germany for four days.
https://www.nytimes.com/video/world/europe/100000010805128/humpback-whale-freed-german-coast.html?smid=url-share
about 2 months ago
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The Diversity of Transplant Glomerulitis and its Relationship to Alloantibody
www.kireports.org/article/S246...
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The Diversity of Transplant Glomerulitis and its Relationship to Alloantibody
Although transplant glomerulitis often signifies antibody-mediated rejection (AMR), the pathophysiology of complement degradation split-product 4d (C4d) staining of peritubular capillaries (C4dptc) an...
https://www.kireports.org/article/S2468-0249%2826%2902609-4/fulltext
about 2 months ago
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Politicisation of the US FDA: eroding integrity and trust - The Lancet
www.thelancet.com/journals/lan...
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Politicisation of the US FDA: eroding integrity and trust
The principle that medicines should not reach patients without strong safety guardrails forms the bedrock of the US Food and Drug Administration (FDA). The FDA shapes decisions about which medicines r...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2826%2900600-8/fulltext
about 2 months ago
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Worldās oldest dog identified at ancient hunter-gatherer site
www.science.org/content/arti...
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Worldās oldest dog identified at ancient hunter-gatherer site
Bones of 15,800-year-old puppy push confirmed origin of our canine companions back nearly 5000 years
https://www.science.org/content/article/world-s-oldest-dog-identified-ancient-hunter-gatherer-site?utm_campaign=Science+Magazine&utm_medium=ownedSocial&utm_source=bluesky
about 2 months ago
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Finding the etiology of MPGN - Kidney International
www.kidney-international.org/article/S008...
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Finding the etiology of MPGN
Membranoproliferative glomerulonephritis (MPGN) has undergone a change in classification that is focused on the etiology of MPGN. Thus, MPGN is classified into immune-complex (IC)-mediated MPGN and co...
https://www.kidney-international.org/article/S0085-2538%2826%2900228-0/fulltext
about 2 months ago
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JCI Insight - Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome
insight.jci.org/articles/vie...
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JCI Insight - Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome
https://insight.jci.org/articles/view/197643
about 2 months ago
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Updates on kidney transplant from the WTC 2025:
www.instagram.com/reel/DV1AP8r...
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transplantation_journal on Instagram: "Paolo Cravedi with Udpates on Kidney Transplantation from the WTC 2025 šThe link to the full article can be found in our Bio š#trā¦"
Paolo Cravedi with Udpates on Kidney Transplantation from the WTC 2025 šThe link to the full article can be found in our Bio š#transplantation #kidneytransplant #worldtransplantcongress #transplantimmunology #paper
https://www.instagram.com/reel/DV1AP8rlOSO/?utm_source=ig_web_button_share_sheet
about 2 months ago
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Anti-PLA2R1 IgG-mediated podocyte PLA2R1 cleavage drives glomerular subepithelial immune complex deposition in membranous nephropathy
www.kidney-international.org/article/S008...
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Anti-PLA2R1 IgG-mediated podocyte PLA2R1 cleavage drives glomerular subepithelial immune complex deposition in membranous nephropathy
In membranous nephropathy (MN), subepithelial immune deposits and glomerular basement membrane (GBM) thickening are defining lesions, yet how circulating anti-phospholipase A2 receptor 1 (PLA2R1) IgG ...
https://www.kidney-international.org/article/S0085-2538%2826%2900164-X/fulltext
about 2 months ago
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Is It Time to Review How We Use Proteinuria to Define Disease Activity in Glomerular Diseases?
journals.lww.com/jasn/citatio...
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https://journals.lww.com/jasn/citation/9900/is_it_time_to_review_how_we_use_proteinuria_to.955.aspx
about 2 months ago
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Executive Summary of ASN Kidney Health Guidance on Conservative Management in People with Kidney Failure
journals.lww.com/jasn/fulltex...
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https://journals.lww.com/jasn/fulltext/9900/executive_summary_of_asn_kidney_health_guidance_on.962.aspx
about 2 months ago
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Knockdown of swine leukocyte antigen expression in porcine lung transplants enables graft survival without immunosuppression
www.science.org/doi/10.1126/...
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Knockdown of swine leukocyte antigen expression in porcine lung transplants enables graft survival without immunosuppression
Down-regulation of swine leukocyte antigen expression supports graft survival after allogeneic lung transplantation in minipigs.
https://www.science.org/doi/10.1126/scitranslmed.adi9548
about 2 months ago
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N-Propargylglycine Restores Survival by Preventing Calcium Oxalate Stone Formation, Tubular Injury, and Kidney Dysfunction in a Lethal Mouse Model of Primary Hyperoxaluria Type 2
www.kidney-international.org/article/S008...
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N-Propargylglycine Restores Survival by Preventing Calcium Oxalate Stone Formation, Tubular Injury, and Kidney Dysfunction in a Lethal Mouse Model of Primary Hyperoxaluria Type 2
New therapeutics are needed to address the rapid progression of calcium oxalate (CaOx) nephrolithiasis and life-threatening kidney failure afflicting infants and young adults with one of the three dif...
https://www.kidney-international.org/article/S0085-2538%2826%2900218-8/fulltext
about 2 months ago
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reposted by
Cravedi Lab
Science Magazine
about 2 months ago
Slow-motion videos reveal tree frogs making some of the most dramatic landings in nature. Learn more on
#WorldFrogDay
:
https://scim.ag/3Nnd04A
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Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention - The Lancet
www.thelancet.com/journals/lan...
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Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention
A behavioural intervention programme to promote fluid intake for secondary stone prevention did not reduce recurrent stone events but modestly increased urine volume compared with guideline-based care...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2825%2902637-6/fulltext
about 2 months ago
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Why the research money isnāt flowing from NSF and NIH
www.science.org/content/arti...
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Analysis: Why the research money isnāt flowing from NSF and NIH
White House review of agency spending plans for this year is causing delays
https://www.science.org/content/article/analysis-why-research-money-isn-t-flowing-nsf-and-nih?utm_campaign=Science+Magazine&utm_medium=ownedSocial&utm_source=bluesky
2 months ago
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reposted by
Cravedi Lab
ASN Publications
2 months ago
ASNās 2026 STAND for Kidney Health reflects a comprehensive strategy: Prevent disease where possible, fix whatās broken, invest in the future, support the people who deliver care, and make the system work better for people living with kidney diseases. #ASNKidneyNews:
kidney.pub/KN1803-05
#ASNKidneyNews:
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Lifelong behavioral screen reveals an architecture of vertebrate aging | Science
www.science.org/doi/10.1126/...
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Lifelong behavioral screen reveals an architecture of vertebrate aging
Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...
https://www.science.org/doi/10.1126/science.aea9795
2 months ago
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Inhibition of T cell polyamine metabolism promotes transplant acceptance by modulating cytotoxic CD8+ T cell differentiation - American Journal of Transplantation
www.amjtransplant.org/article/S160...
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Inhibition of T cell polyamine metabolism promotes transplant acceptance by modulating cytotoxic CD8+ T cell differentiation
Polyamines, particularly spermidine, are well-documented for their cardiovascular protective, antitumor, and longevity-promoting properties. However, their role in heart transplantation, and specifica...
https://www.amjtransplant.org/article/S1600-6135%2826%2900124-3/fulltext
2 months ago
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Genetically modified pig liver keeps man alive until human organ transplant
www.nature.com/articles/d41...
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Genetically modified pig liver keeps man alive until human organ transplant
First time the procedure has been performed on a living person.
https://www.nature.com/articles/d41586-026-00736-0
2 months ago
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www.sciencedirect.com/science/arti...
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Mechanistic insights from transcript analysis of long-term pig to non-human primate kidney xenografts
Porcine xenografts are a potential future organ source. Limited short-term clinical studies have suggested different mechanisms in xenografts than allā¦
https://www.sciencedirect.com/science/article/pii/S0085253825010087
2 months ago
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Cytotoxic T cells enhance tissue inflammation by secreting proteases like GZMK to induce local complement activation
www.sciencedirect.com/science/arti...
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Granzyme K sets complement in motion
https://www.sciencedirect.com/science/article/pii/S0085253825007525
2 months ago
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Anti-CMV immunotoxin during ex vivo machine perfusion: are we ready for CMV-negative transplantation? - American Journal of Transplantation
www.amjtransplant.org/article/S160...
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Anti-CMV immunotoxin during ex vivo machine perfusion: are we ready for CMV-negative transplantation?
Recent progress in the management and prevention of cytomegalovirus (CMV) infection has reduced the burden of CMV after organ transplantation (1). Low-risk CMV seropositive recipients (R+) who may nee...
https://www.amjtransplant.org/article/S1600-6135%2826%2900114-0/fulltext
2 months ago
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Can low serum complement be used as an indicator of thrombotic microangiopathy in kidney transplant candidates with unknown diagnosis? url:
academic.oup.com/joneph/artic...
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Can low serum complement be used as an indicator of thrombotic microangiopathy in kidney transplant candidates with unknown diagnosis?
Many patients reach kidney failure with unknown or misdiagnosed primary kidney disease. This is a major clinical issue because some native diseases, includ
https://academic.oup.com/joneph/article-abstract/doi/10.1093/joneph/aajaf004/8459080
2 months ago
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reposted by
Cravedi Lab
American Journal of Transplantation
3 months ago
šØ Editorās Choice šØ "Erythropoietin prolongs graft survival in mice by counteracting trained immunity," by Bin et al
www.amjtransplant.org/article/S160...
@cravedilab.bsky.social
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B-cell maturation antigen-Targeted T-cell Engager Therapy Combined with B cell Depletion for Treatment of Refractory HLA Sensitization - Kidney International
www.kidney-international.org/article/S008...
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B-cell maturation antigen-Targeted T-cell Engager Therapy Combined with B cell Depletion for Treatment of Refractory HLA Sensitization
Preformed, high-titer anti-human leukocyte antigen (HLA) antibodies remain a major barrier to successful kidney transplantation, increasing the risk of early graft loss and prolong time on dialysis. D...
https://www.kidney-international.org/article/S0085-2538%2826%2900092-X/fulltext
3 months ago
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reposted by
Cravedi Lab
Oded Rechavi
3 months ago
Getting into the mood to review a grant
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reposted by
Cravedi Lab
3 months ago
Recurrence of C3 Glomerulopathy and Immune ComplexāMediated Membranoproliferative Glomerulonephritis After #Kidney #Transplantation: Challenges and Opportunities
https://doi.org/10.1016/j.ekir.2025.11.008
#Kidney
#Transplantation
#C3Glomerulopathy
#KIRReview
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Updates on Kidney Transplantation From the World Transplant Congress 2025
journals.lww.com/transplantjo...
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https://journals.lww.com/transplantjournal/abstract/9900/updates_on_kidney_transplantation_from_the_world.1307.aspx
3 months ago
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Very insightful read:
www.nature.com/articles/s41...
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On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
https://www.nature.com/articles/s41577-026-01276-4
3 months ago
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reposted by
Cravedi Lab
Žiga Avsec
4 months ago
AlphaGenome is out in
@nature.com
today along with model weights! š§¬ š Paper:
www.nature.com/articles/s41...
š» Weights:
github.com/google-deepm...
Getting here wasnāt a straight path. We discussed the story behind the model, paper & API in the following roundtable:
youtu.be/V8lhUqKqzUc
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Thomas Fogarty, 91, Who Helped Revolutionize Vascular Surgery, Dies
www.nytimes.com/2026/01/26/s...
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Thomas Fogarty, 91, Who Helped Revolutionize Vascular Surgery, Dies
https://www.nytimes.com/2026/01/26/science/thomas-fogarty-dead.html?smid=bs-share
4 months ago
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Combined Anti-CD20/Anti-CD38 Therapy in Posttransplant Focal Segmental Glomerulosclerosis Recurrence: A Retrospective, International, Multicenter Study
journals.lww.com/transplantat...
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https://journals.lww.com/transplantationdirect/fulltext/2026/02000/combined_anti_cd20_anti_cd38_therapy_in.10.aspx
4 months ago
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Final funding bill for NIH pushes back against Trump cuts | Science | AAAS
www.science.org/content/arti...
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Final funding bill for NIH pushes back against Trump cuts
Measure gives agency slight boost and blocks multiyear awards and cuts to indirect costs
https://www.science.org/content/article/final-funding-bill-nih-pushes-back-against-trump-cuts?__cf_chl_tk=IdyGqR8L24EKAOVxrI_ps2Fvp9w.lDGpeynlRSTlLOk-1768939691-1.0.1.1-6yx8YXZZ4BUrz0jmDe.uUB03JitMIGHMe_9ly3_HSNg
4 months ago
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B Cell Depletion in Glomerular Diseases: Not Always as Safe as We May Think - Kidney Medicine
www.kidneymedicinejournal.org/article/S259...
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B Cell Depletion in Glomerular Diseases: Not Always as Safe as We May Think
B cell depletion with chimeric anti-CD20 monoclonal antibody rituximab has revolutionized the treatment of glomerular diseases. Obinutuzumab, a type II glycoengineered anti-CD20 humanized monoclonal a...
https://www.kidneymedicinejournal.org/article/S2590-0595%2826%2900029-4/fulltext
4 months ago
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Chronic kidney disease - The Lancet
www.thelancet.com/journals/lan...
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Chronic kidney disease
Globally, the prevalence of chronic kidney disease is estimated to be approximately 850 million cases, with approximately 4 million individuals needing kidney replacement therapy for kidney failure. B...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2825%2901942-7/fulltext
4 months ago
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Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients: Immunity
www.cell.com/immunity/ful...
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Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients
Donor-specific antibodies against mismatched HLA proteins cause allograft failure, but the structural epitopes recognized by these antibodies are not well defined. Killian et al. identify immunodomina...
https://www.cell.com/immunity/fulltext/S1074-7613%2825%2900466-2
4 months ago
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