Cravedi Lab
@cravedilab.bsky.social
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📥 181
📝 347
Kidney & Immunology Research at Icahn School of Medicine at Mount Sinai
reposted by
Cravedi Lab
Žiga Avsec
5 days ago
AlphaGenome is out in
@nature.com
today along with model weights! 🧬 📄 Paper:
www.nature.com/articles/s41...
💻 Weights:
github.com/google-deepm...
Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable:
youtu.be/V8lhUqKqzUc
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Thomas Fogarty, 91, Who Helped Revolutionize Vascular Surgery, Dies
www.nytimes.com/2026/01/26/s...
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Thomas Fogarty, 91, Who Helped Revolutionize Vascular Surgery, Dies
https://www.nytimes.com/2026/01/26/science/thomas-fogarty-dead.html?smid=bs-share
7 days ago
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Combined Anti-CD20/Anti-CD38 Therapy in Posttransplant Focal Segmental Glomerulosclerosis Recurrence: A Retrospective, International, Multicenter Study
journals.lww.com/transplantat...
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https://journals.lww.com/transplantationdirect/fulltext/2026/02000/combined_anti_cd20_anti_cd38_therapy_in.10.aspx
11 days ago
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Final funding bill for NIH pushes back against Trump cuts | Science | AAAS
www.science.org/content/arti...
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Final funding bill for NIH pushes back against Trump cuts
Measure gives agency slight boost and blocks multiyear awards and cuts to indirect costs
https://www.science.org/content/article/final-funding-bill-nih-pushes-back-against-trump-cuts?__cf_chl_tk=IdyGqR8L24EKAOVxrI_ps2Fvp9w.lDGpeynlRSTlLOk-1768939691-1.0.1.1-6yx8YXZZ4BUrz0jmDe.uUB03JitMIGHMe_9ly3_HSNg
13 days ago
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B Cell Depletion in Glomerular Diseases: Not Always as Safe as We May Think - Kidney Medicine
www.kidneymedicinejournal.org/article/S259...
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B Cell Depletion in Glomerular Diseases: Not Always as Safe as We May Think
B cell depletion with chimeric anti-CD20 monoclonal antibody rituximab has revolutionized the treatment of glomerular diseases. Obinutuzumab, a type II glycoengineered anti-CD20 humanized monoclonal a...
https://www.kidneymedicinejournal.org/article/S2590-0595%2826%2900029-4/fulltext
18 days ago
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Chronic kidney disease - The Lancet
www.thelancet.com/journals/lan...
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Chronic kidney disease
Globally, the prevalence of chronic kidney disease is estimated to be approximately 850 million cases, with approximately 4 million individuals needing kidney replacement therapy for kidney failure. B...
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2825%2901942-7/fulltext
about 1 month ago
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Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients: Immunity
www.cell.com/immunity/ful...
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Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients
Donor-specific antibodies against mismatched HLA proteins cause allograft failure, but the structural epitopes recognized by these antibodies are not well defined. Killian et al. identify immunodomina...
https://www.cell.com/immunity/fulltext/S1074-7613%2825%2900466-2
about 1 month ago
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reposted by
Cravedi Lab
The New York Times
about 1 month ago
After eight years of training, Dr. Maureen McKiernan had 90 minutes to get a beating heart inside a 6-month-old infant. It was her first heart transplant as the lead surgeon and her first ever in an infant. Here's a look at the steps in the milestone operation.
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90 Minutes to Give Baby Luna a New Heart
After eight years of training, Dr. Maureen McKiernan made her debut as the lead surgeon on an infant heart transplant — an operation on the edge of what’s possible.
https://nyti.ms/4qdnsJS
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reposted by
Cravedi Lab
Itai Yanai
about 1 month ago
With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.
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Promoting Equity in Transplant Research by Addressing the Exclusion of Patients With Glomerular Disease - Kidney International Reports
www.kireports.org/article/S246...
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Promoting Equity in Transplant Research by Addressing the Exclusion of Patients With Glomerular Disease
Kidney transplantation remains the treatment of choice for patients with end-stage kidney disease (ESKD), offering superior survival and quality of life compared with dialysis.1 Despite improvements i...
https://www.kireports.org/article/S2468-0249%2825%2900617-5/fulltext
about 1 month ago
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reposted by
Cravedi Lab
Oded Rechavi
about 2 months ago
When your PI presents your work
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Reaching maturity: Thymic γδ T cell differentiation in mice and humans | Science Immunology
www.science.org/doi/10.1126/...
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Reaching maturity: Thymic γδ T cell differentiation in mice and humans
γδ T cell differentiation into specialized effector subsets during both early life and adulthood is reviewed.
https://www.science.org/doi/10.1126/sciimmunol.adn2093
about 2 months ago
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Short-term glyco-editing during machine perfusion permits ABO-incompatible transplantation in a human decedent model
www.sciencedirect.com/science/arti...
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Short-term glyco-editing during machine perfusion permits ABO-incompatible transplantation in a human decedent model
https://www.sciencedirect.com/science/article/pii/S1600613525031703
about 2 months ago
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Increased Treg in Kidney Transplant Recipients With Erythrocytosis
www.frontierspartnerships.org/journals/tra...
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Frontiers Publishing Partnerships | Increased Treg in Kidney Transplant Recipients With Erythrocytosis
Dear Editors, Erythropoietin (EPO) is a glycoprotein hormone produced predominantly by the kidney in response to hypoxia. While widely known for its hematopo...
https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2025.15845/full#share
about 2 months ago
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reposted by
Cravedi Lab
Waggoner Lab
about 2 months ago
Preprint: CD19-directed CAR-T-cell therapy can induce rapid, durable remission of severe, refractory cold-agglutinin AIHA and simultaneously improve coexisting APLAS and ITP on a favorable toxicity profile
papers.ssrn.com/sol3/papers....
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CD19 CAR-T-Cell Therapy in Refractory Autoimmune Hemolytic Anemia (AIHA) With Concurrent Immune Thrombocytopenia (ITP) and Antiphospholipid Antibody Syndrome (APLAS)
Background: Autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), and antiphospholipid antibody syndrome (APLAS) are B-cell–driven autoimmune
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5856135
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reposted by
Cravedi Lab
NY-CURES
2 months ago
📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️
c.org/TDMy2H9JTW
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Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
https://c.org/TDMy2H9JTW
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www.science.org/content/arti...
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Can AI capture the mind-boggling complexity of a human cell?
Researchers are competing to make “virtual cells” that could transform biomedicine by predicting gene activity and more
https://www.science.org/content/article/can-ai-capture-mind-boggling-complexity-human-cell
2 months ago
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www.science.org/content/arti...
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With winged legs, orchid mantis sets gliding record
Camouflaged like a flower, these predators also have a getaway trick
https://www.science.org/content/article/winged-legs-orchid-mantis-sets-gliding-record?utm_campaign=Science+Magazine&utm_source=bluesky&utm_medium=ownedSocial
2 months ago
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Kidney transplantation across ABO-H incompatibility in a recipient with Bombay blood group: A novel report - American Journal of Transplantation
www.amjtransplant.org/article/S160...
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Kidney transplantation across ABO-H incompatibility in a recipient with Bombay blood group: A novel report
The Bombay blood group is an exceptionally rare phenotype characterized by the absence of H antigen on red blood cells due to mutations in the FUT1 gene and absence of H substance in secretions from c...
https://www.amjtransplant.org/article/S1600-6135%2825%2903101-6/fulltext
2 months ago
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Increased Treg in Kidney Transplant Recipients With Erythrocytosis
www.frontierspartnerships.org/journals/tra...
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Frontiers Publishing Partnerships | Increased Treg in Kidney Transplant Recipients With Erythrocytosis
Dear Editors, Erythropoietin (EPO) is a glycoprotein hormone produced predominantly by the kidney in response to hypoxia. While widely known for its hematopo...
https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2025.15845/full
2 months ago
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JCI - Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9
www.jci.org/articles/vie...
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JCI - Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9
https://www.jci.org/articles/view/186258
2 months ago
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The Gut–Kidney Axis and Effect on GFR
journals.lww.com/jasn/citatio...
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https://journals.lww.com/jasn/citation/9900/the_gut_kidney_axis_and_effect_on_gfr.832.aspx
2 months ago
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Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports
www.embopress.org/doi/full/10....
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Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue | EMBO reports
imageimageStressed brown adipocytes release extracellular ATP, which acts as a paracrine signal via P2X4 and P2X7 receptors on macrophages, initiating BAT inflammatory remodeling and degeneration. Blo...
https://www.embopress.org/doi/full/10.1038/s44319-025-00642-y
2 months ago
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Macrophage metabolic reprogramming influences adult growth
www.embopress.org/toc/14693178...
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EMBO reports: Vol 26, No 22
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
https://www.embopress.org/toc/14693178/26/22
2 months ago
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From progression to remission: a new paradigm for success in chronic kidney disease - Kidney International
www.kidney-international.org/article/S008...
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From progression to remission: a new paradigm for success in chronic kidney disease
Recent advances in treatment of chronic kidney disease have changed the clinical paradigm from slowing inevitable progression to achievable remission. Landmark trials involving sodium-glucose cotransp...
https://www.kidney-international.org/article/S0085-2538%2825%2900847-6/fulltext
3 months ago
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An islet-resident macrophage antioxidant program preserves β cell physiology | Science Immunology
www.science.org/doi/10.1126/...
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An islet-resident macrophage antioxidant program preserves β cell physiology
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis.
https://www.science.org/doi/10.1126/sciimmunol.adz5181?utm_campaign=Science+Magazine&utm_medium=ownedSocial&utm_source=bluesky
3 months ago
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A Comprehensive comparative assessment of mean Fluorescence Intensity of Luminex single Antigen bead tests between laboratories and commercial platforms
@umaggiore.bsky.social
www.sciencedirect.com/science/arti...
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A Comprehensive comparative assessment of mean Fluorescence Intensity of Luminex single Antigen bead tests between laboratories and commercial platforms: A report from the Italian Histocompatibility N...
Reliable and reproducible testing of Donor Specific HLA-Antibodies (DSA) is essential for clinical decisions in organ transplantation. In this prospec…
https://www.sciencedirect.com/science/article/abs/pii/S0198885925003829?via%3Dihub
3 months ago
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reposted by
Cravedi Lab
Science Magazine
3 months ago
An early Triassic bone bed excavated at 78°N changes the story about how marine life recovered after the most cataclysmic extinction in Earth history ~252 million years ago. Learn more in this week's issue of Science:
https://scim.ag/48bLsGI
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reposted by
Cravedi Lab
Life Science Network
3 months ago
New method could improve manufacturing of gene-therapy drugs.
#science
#news
www.lifescience.net/news/6673/ne...
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New method could improve manufacturing of gene-therapy drugs
Selective crystallization can greatly improve the purity, selectivity, and active yield of viral vector-based gene therapy drugs, study finds.
https://www.lifescience.net/news/6673/new-method-could-improve-manufacturing-of-gene-the/
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Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes url:
jamanetwork.com/journals/jam...
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Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes
This meta-analysis evaluates the prevalence and characteristics of discordance between creatinine- and cystatin C–based estimated glomerular filtration rate as well as the association of discordance w...
https://jamanetwork.com/journals/jama/fullarticle/2841167?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=110725
3 months ago
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JCI - GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity
www.jci.org/articles/vie...
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JCI - GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity
https://www.jci.org/articles/view/194749
3 months ago
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Drug repurposing in PIK3CA-related overgrowth spectrum: breakthroughs from overgrowth syndromes to kidney disease - Kidney International
www.kidney-international.org/article/S008...
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Drug repurposing in PIK3CA-related overgrowth spectrum: breakthroughs from overgrowth syndromes to kidney disease
PI3Kα is a ubiquitous lipid kinase that transduces extracellular growth, proliferation and metabolism signals. Genes involved in the PI3Kα signaling pathway are frequently mutated in cancer. Apart fro...
https://www.kidney-international.org/article/S0085-2538%2825%2900837-3/fulltext
3 months ago
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reposted by
Cravedi Lab
Simone Sanna-Cherchi 🧬
4 months ago
Exciting expansion!!
#FSGS
#APOL1
add a skeleton here at some point
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Subzero Kidney Preservation Comes to Scale - American Journal of Transplantation
www.amjtransplant.org/article/S160...
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Subzero Kidney Preservation Comes to Scale
Since the 1980s, static cold storage (SCS), and its close cousin hypothermic perfusion, have been the standard preservation methods for kidney grafts. Nevertheless, hypothermic temperatures (4 to 0°C)...
https://www.amjtransplant.org/article/S1600-6135%2825%2903063-1/fulltext
3 months ago
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Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
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Epigenetic regulation of T cell exhaustion in cancer - Nature Reviews Cancer
Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...
https://www.nature.com/articles/s41568-025-00883-y
3 months ago
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Biomarkers in CKD:What Does the Future Hold?
journals.lww.com/jasn/citatio...
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https://journals.lww.com/jasn/citation/9900/biomarkers_in_ckd__what_does_the_future_hold_.812.aspx
3 months ago
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Daratumumab Efficacy in Steroid-Resistant Nephrotic Syndrome Correlates with CD38+ B-Cell Depletion
www.kireports.org/article/S246...
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Daratumumab Efficacy in Steroid-Resistant Nephrotic Syndrome Correlates with CD38+ B-Cell Depletion
The anti-CD38 monoclonal antibody daratumumab, alone or with anti-CD20 rituximab, can induce remission in steroid-resistant nephrotic syndrome or multidrug-dependent nephrotic syndrome.1 However, the ...
https://www.kireports.org/article/S2468-0249(25)00482-6/fulltext
3 months ago
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Mucin O-glycosylation and B cell homing: a new bridge for the gut-kidney axis in IgA nephropathy?
www.kidney-international.org/article/S008...
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Mucin O-glycosylation and B cell homing: a new bridge for the gut-kidney axis in IgA nephropathy?
IgA nephropathy (IgAN) is an insidious autoimmune glomerulonephritis that often progresses to end-stage kidney failure, despite anti-inflammatory and anti-proteinuric therapies1. An evolving understan...
https://www.kidney-international.org/article/S0085-2538%2825%2900784-7/fulltext
3 months ago
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Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes
www.kidney-international.org/article/S008...
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Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes
Prediabetes, an intermediate state between normoglycemia and type 2 diabetes affecting 720 million individuals worldwide, is associated with hyperfiltration, an early stage of diabetic kidney disease....
https://www.kidney-international.org/article/S0085-2538%2825%2900519-8/fulltext
3 months ago
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Proinflammatory and cytotoxic CD38+HLA-DR+ effector memory CD8+ T cells are peripherally expanded in human cardiac allograft vasculopathy
www.amjtransplant.org/article/S160...
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Proinflammatory and cytotoxic CD38+HLA-DR+ effector memory CD8+ T cells are peripherally expanded in human cardiac allograft vasculopathy
Interferon-γ (IFNG) is thought to play a central role in the pathogenesis of cardiac allograft vasculopathy (CAV) in heart transplant (HTx) patients. However, peripheral lymphocytes participating in t...
https://www.amjtransplant.org/article/S1600-6135%2825%2903062-X/fulltext
3 months ago
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Educational Strategies to Prepare Trainees for Clinical Uncertainty | New England Journal of Medicine
www.nejm.org/doi/full/10....
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Educational Strategies to Prepare Trainees for Clinical Uncertainty | NEJM
Uncertainty is ubiquitous in the practice of medicine. This review characterizes clinical uncertainty and shows how teachers can guide learners to recognize, manage, and communicate uncertainty in ...
https://www.nejm.org/doi/full/10.1056/NEJMra2408797?query=featured_secondary_home
3 months ago
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reposted by
Cravedi Lab
American Journal of Transplantation
3 months ago
Part of our virtual special issue, Best Practices for Mouse Models of Organ Transplantation: Check out the article, "Best Practices in Mouse Models of Skin Transplantation" by Borges et al. Online & in press!
www.amjtransplant.org/article/S160...
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A new chapter in the EPO Saga! Erythropoietin prolongs graft survival in mice by counteracting trained immunity - American Journal of Transplantation
www.amjtransplant.org/article/S160...
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Erythropoietin prolongs graft survival in mice by counteracting trained immunity
Upon activation, macrophages undergo epigenetic and metabolic reprogramming, resulting in stronger responses to subsequent insults (trained immunity), and, in the case of transplant, in accelerated re...
https://www.amjtransplant.org/article/S1600-6135%2825%2903060-6/fulltext
3 months ago
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AI Will Offer New Opportunities for Transplantation: Are We Ready?
journals.lww.com/transplantat...
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https://journals.lww.com/transplantationdirect/fulltext/2025/06000/ai_will_offer_new_opportunities_for.12.aspx
4 months ago
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reposted by
Cravedi Lab
Marc Veldhoen
4 months ago
Very good 😂. This describes a lot of what is going on accurately. Credit:
@integralanswers.bsky.social
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Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors: Cell Reports Medicine
www.cell.com/cell-reports...
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Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors
Niu et al. construct the circCV-B3 vector to enable scarless circRNA engineering. Utilizing circCV-B3 vector, they engineer circILNb for co-encoding IL-15 and anti-PD-L1 nanobody. Additionally, they d...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791%2825%2900486-0
4 months ago
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The fading darling: Patient voice as the future of transplant trust
www.amjtransplant.org/article/S160...
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The fading darling: Patient voice as the future of transplant trust
Organ transplantation saves tens of thousands of lives annually. As a renal recipient, I am counted among those many miracles. Unfortunately, the field is quickly slipping from its position as the dar...
https://www.amjtransplant.org/article/S1600-6135(25)02985-5/abstract
4 months ago
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Sildenafil Modulates Dendritic Cell Motility as a New Immunomodulatory Strategy
www.amjtransplant.org/article/S160...
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Sildenafil Modulates Dendritic Cell Motility as a New Immunomodulatory Strategy
Targeting dendritic-cell motility via the PDE5–cGMP axis offers a new path to modulate tumor and potentially transplant immunity.
https://www.amjtransplant.org/article/S1600-6135(25)03009-6/abstract
4 months ago
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Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model - American Journal of Transplantation
www.amjtransplant.org/article/S160...
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Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model
Despite much-improved protocols that broadly suppress the adaptive immune cells, most allografts are still lost to chronic rejection, in which macrophages have been prominently featured in the graft. ...
https://www.amjtransplant.org/article/S1600-6135%2825%2902848-5/fulltext
4 months ago
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Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy - Kidney International
www.kidney-international.org/article/S008...
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Hierarchical clustering uncovered disease patterns and further untangled complexities in immune complex-mediated idiopathic MPGN and C3 glomerulopathy
Membranoproliferative glomerulonephritis (MPGN) is currently stratified into complement C3 glomerulopathy (C3G) and immune complex-mediated MPGN (IC-MPGN). However, classification is subject to contin...
https://www.kidney-international.org/article/S0085-2538%2825%2900772-0/fulltext
4 months ago
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