Josh Leisring
@joshleisring.bsky.social
📤 231
📥 118
📝 90
Nephrologist / Hypertension Specialist in Columbus, Ohio
#Nephsky
He / him
reposted by
Josh Leisring
Swapnil Hiremath 🍁🇨🇦
8 days ago
Cuffless BP review with
@farahwehbe92.bsky.social
- incoming HT fellow in Ottawa, with tables, and details of technology, devices and ongoing trials
pubmed.ncbi.nlm.nih.gov/41460057/
thanks to
@profdg.bsky.social
for the invite!
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Cuffless blood pressure in 2025: from promise to practice: a narrative review - PubMed
Cuffless wearables may be used as adjuncts to surface patterns and support engagement; diagnosis and treatment decisions must be confirmed with validated upper-arm measurements. A pragmatic "good-enough" checklist includes stable calibration over weeks, accuracy across dynamic states and subgroups, …
https://pubmed.ncbi.nlm.nih.gov/41460057/
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Josh Leisring
J. Brian Byrd
24 days ago
Dan Batlle & I wrote about testing for primary aldosteronism, bringing a critical lens to the usual approach
www.ahajournals.org/doi/full/10....
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American Heart Association Journals
https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.125.25990
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Josh Leisring
24 days ago
🚨 Fresh Hypertension Guidelines Alert 🚨 Don’t get caught treating high blood pressure like it’s 2024 👀 In Episode #509, West Philly doc Dr. Jordy Cohen
@jordybc.bsky.social
keeps our hypertension management fresh with a clear walk-through of the new HTN guidelines & more!
www.thecurbsiders.com
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AHA Scientific Statement on Single-Pill Combination Therapy
www.ahajournals.org/doi/10.1161/...
#Nephsky
about 1 month ago
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Josh Leisring
Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS
about 1 month ago
If you are interested in hypertension training and research, check out our hypertension fellowship.
research.bidmc.org/medicine-gme...
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Clinical Hypertension Fellowship
https://research.bidmc.org/medicine-gme/clinical-hypertension-fellowship
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Josh Leisring
Stephen P Juraschek, MD, PhD, FAHA, AHSCP-CHS
about 1 month ago
Happy to contribute to this important statement
@ahascience.bsky.social
on cuffless devices led by
@jordybc.bsky.social
! Cuffless Devices for the Measurement of Blood Pressure: A Scientific Statement From the American Heart Association | Hypertension
ahajournals.org/doi/10.1161/...
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"Older and Black participants had higher aldo-to-renin ratio...and women had higher aldo levels than men across the lifespan. With newly expanded indications for PA testing, a greater appreciation of the influence of demographic characteristics will be required."
#nephsky
tinyurl.com/yc8ryxmu
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Impact of Age, Sex, and Race on Primary Aldosteronism Test Interpretations | Hypertension
BACKGROUND: New guidelines recommend testing for primary aldosteronism (PA) in all people with hypertension. Interpreting population-based results for PA will require understanding the influence of de...
https://tinyurl.com/yc8ryxmu
about 1 month ago
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
about 1 month ago
Our take on the baxdrostat PA trial in
@asnpublications.bsky.social
#KidneyNews
www.kidneynews.org/view/journal...
with
@nephroseeker.medsky.social
and
@dramiliflores.bsky.social
! Thanks to Sam Kant and
@kdjhaveri.bsky.social
for the invite!!
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reposted by
Josh Leisring
Nephrology Journal Club
about 1 month ago
🆕
#NephJCshort
by
@brianrifkin.bsky.social
RETREAT-FRAIL- pragmatic RCT: is less BP medication worse in octogenarians?
www.nephjc.com/news/hyperte...
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NephJC Shorts: Hypertension and The Extreme Elderly — NephJC
The NephJC shorts version of the Hypertension medication step-down in a nursing home population from NEJM
https://www.nephjc.com/news/hypertension-nursinghome
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Josh Leisring
about 1 month ago
My first month of trying to prescribe fish oil at the dialysis unit has been a total failure Pharmacies arn’t filling scripts and patients can’t find OTC matches to dose prescribed in PISCES Anyone having success on the high seas?
add a skeleton here at some point
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Josh Leisring
haysamrady
about 2 months ago
To Treat or Not to Treat? Watchful Waiting or Oral Antihypertensives for Asymptomatic Inpatient Hypertension
#nephsky
#nephrology
www.nejm.org/doi/full/10....
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To Treat or Not to Treat? Watchful Waiting or Oral Antihypertensives for Asymptomatic Inpatient Hypertension | NEJM
This feature about a man hospitalized for uncomplicated diverticulitis who is found to have high blood pressure offers a case vignette accompanied by two essays, one supporting ...
https://www.nejm.org/doi/full/10.1056/NEJMclde2502632?query=RES
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Josh Leisring
Vivek Bhalla, MD, FASN, FAHA
2 months ago
Ahead of
#KidneyWk25
, we are recruiting a hypertension fellow to the Stanford Hypertension Center for July 2026. Please come find me at ASN.
med.stanford.edu/nephrology/e...
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Hypertension Fellowship
https://med.stanford.edu/nephrology/education/fellowship/hypertensionfellowship.html
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Josh Leisring
Michelle Rheault, MD
2 months ago
Samir Parikh gives an update on lupus nephritis.
#KidneyWk
Looking for rapid reduction of proteinuria? Voclosporin is faster, but belimumab showed similar separation from placebo, it just takes longer due to mechanism of action.
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Josh Leisring
NEJM.org
3 months ago
BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video.
nej.md/3KCsQGJ
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Donate and represent!
#NephJC
add a skeleton here at some point
4 months ago
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Josh Leisring
Tim Doulton
4 months ago
Our
@ukkidney.org
guidelines here in BMC Nephrology. 💯% agree that in-unit BP should ONLY be used for determining safety of individual HD sessions and NOT long-term CV risk modification. But changing practice will be a long haul.
link.springer.com/epdf/10.1186...
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Management of blood pressure in adults, children and young people on dialysis: UK kidney association clinical practice guideline
https://link.springer.com/epdf/10.1186/s12882-025-04451-2?sharing_token=gTuf3PvEWX2uESqvgyLeU2_BpE1tBhCbnbw3BuzI2RPyD5ERkuGloJRLBe50mE1_Fw7tkLOmHaqhGqapNF40kWCaUV4L0voxWWUCKG0uq2wETV3LdGaC1LlH9fXU1DsE3jNNuhwWos01g_U_0bDk1-h5eXy5tsbvK8aS6Uk7wc8%3D
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Josh Leisring
John Giacona, PhD, PA-C
4 months ago
Subclinical primary aldosteronism is an under-recognized driver of cardiovascular risk. Could it be a new target for CV prevention? Read our Circulation editorial —>
add a skeleton here at some point
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Josh Leisring
Cristina Popa
4 months ago
#NephJC
is a labor of a passionate volunteer team that believes education should be accessible, no matter where you are from in the world. Even if editorial team donates unlimited hours of sleep, there are still costs to cover 💸 (👇 blog) 😊 Be kind, help us to
#NephItForward
#Medsky
#Nephsky
add a skeleton here at some point
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Josh Leisring
Vivek Bhalla, MD, FASN, FAHA
4 months ago
We are thrilled to announce that we have generously received funding for a one-year hypertension fellowship, and we are recruiting now for a candidate to start fellowship July 1, 2026 .
med.stanford.edu/hypertension/e…
-Jehan Zahid Bahrainwala HTN Fellowship Program Director
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https://med.stanford.edu/hypertension/e…
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Josh Leisring
Nephrology Journal Club
4 months ago
It's that time of year again 🍂🍂🍂 The
#NephJC
Fall pledge drive. Plese give if you are able to support our decades long mission of
#FOAMed
for all.
#NephSky
#MedSky
www.nephjc.com/news/2025/9/22/nephjc-fall-pledge-drive
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NephJC 2025 Fall Pledge Drive — NephJC
Help keep NephJC a vital, original, and unbiased source of medical education.
https://www.nephjc.com/news/2025/9/22/nephjc-fall-pledge-drive
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Josh Leisring
Rémi Goupil
4 months ago
🚨 Survey Alert! Standardized office BP measurements are recommended everywhere, but still underused. We want to hear from you: what are the barriers to using them as a routine in clinical practice? Click here to read the consent form and take the survey:
redcap.link/barriers.to....
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Josh Leisring
Soumya Rangarajan, MD, MPP
4 months ago
My guess is at least 500
#doctors
at my
#hospital
are on H1B visas including at least a few dozen
#hospitalists
, and if we lose even a handful to other countries our house of cards
#healthcare
system will fall apart, let alone all 500+
add a skeleton here at some point
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
4 months ago
Some of my opinions here on
@ajkd.bsky.social
Blog;
ajkdblog.org/2022/01/19/b...
The
@ahascience.bsky.social
also has a scientific statement here from 2023
www.ahajournals.org/doi/full/10....
#NephJC
Catch up
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Blood Pressure Measurement in Dialysis: There’s No Place Like Home (Part 1)
This is a 2-part blog post by #NephJC cofounder, hypertension guru, and longtime AJKD contributor Swapnil Hiremath. In Part 1, he outlines the quandaries of blood pressure management in hemodialysi…
https://ajkdblog.org/2022/01/19/blood-pressure-measurement-in-dialysis-theres-no-place-like-home-part-1/
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Reposting this again - very relevant for
#NephJC
discussion on the new AHA/ACC guidelines.
add a skeleton here at some point
4 months ago
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reposted by
Josh Leisring
Nephrology Journal Club
4 months ago
❤️Check out the VA for the discussion on the AHA/ACC Hypertension Guidelines 9/16/25 at 9pm EST by
@sejalplakhani.bsky.social
#NephJC
#NephSky
#MedSky
www.nephjc.com/news/2025/9/ahaacc-htnguide
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The AHA/ACC 2025 Hypertension Guidelines visual abstract — NephJC
New updated guidance on hypertension including screening for secondary causes, use of renal denervation, hypertension and pregnancy, risk assessment, monitoring and treatment. Check out this wonderfu...
https://www.nephjc.com/news/2025/9/ahaacc-htnguide
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Josh Leisring
Anand Vaidya
4 months ago
To accompany the new ACC/AHA BP guidelines, a practical guide on how to test for Primary Aldosteronism: now recommended for most people with hypertension.
www.jacc.org/doi/10.1016/...
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Josh Leisring
Anand Vaidya
4 months ago
Confirmatory testing (aldosterone suppression testing) for primary aldosteronism: not reliable, or reproducible, for diagnosis or predicting lateralization. Sensitivity at the expense of specificity, and vice-versa. Time to simplify the process
academic.oup.com/ejendo/artic...
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Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism
AbstractBackground. The saline suppression test (SST) and the captopril challenge test (CCT) have traditionally been used to confirm or exclude primary ald
https://academic.oup.com/ejendo/article/193/3/348/8232743
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
5 months ago
Excellent summary of the ACHIEVE trial from
@drsaivani.bsky.social
&
@thekidneywhisperer.bsky.social
#NephJC
chat tomorrow
www.nephjc.com/news/achieve
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In ESRD is spironolactone an overACHIEVEr? — NephJC
This week, we will discuss the ACHIEVE trial. Will spironolactone achieve CV benefits in ESRD?
http://www.nephjc.com/news/achieve
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Josh Leisring
American Journal of Hypertension
5 months ago
#WeekendReads
from
#EditorsChoice
Can you have normal looking adrenal glands with primary aldosteronism? 🔗
academic.oup.com/ajh/article/...
🔓
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Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism
AbstractBackground. Normal-appearing adrenal glands on cross-sectional imaging may still be the source of aldosterone production in primary aldosteronism (
https://academic.oup.com/ajh/article/35/6/561/6457963?searchresult=1
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
5 months ago
The era of ASIs is slowly dawning
www.nejm.org/doi/full/10....
(Yeah spironolactone is just as good and cheaper) Disclosure: we recruited patients for this one
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Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension | NEJM
Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension. In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated systolic blood pr...
https://www.nejm.org/doi/full/10.1056/NEJMoa2507109
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Josh Leisring
John Giacona, PhD, PA-C
5 months ago
❓What’s new in BP care? 🎥 Watch the
#TargetBP
webinar on the 2025 @AHAScience / @ACCinTouch Hypertension Guidelines w/
@drwanpen.bsky.social
,
@jordybc.bsky.social
, Keith Ferdinand, & Dan Jones 👉
targetbp.org
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
5 months ago
The CPC from last
@ahascience.bsky.social
#HypertensionSessions
now published in
@ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
thanks to
@drjmluther.bsky.social
and all the education editors for the invite We hope it makes for an educational read!
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
5 months ago
More on Hydra-ANCA-zine Four cases, and review of previous (~ 169) cases reported in the literature
academic.oup.com/ckj/article-...
in
@ckj-era.bsky.social
#NephSky
#Hydralazine
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Hydralazine-induced antineutrophil cytoplasmic antibody-associated glomerulonephritis
Antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) can lead to multi-organ failure and death [1, 2]. As an antihypertensive medica
https://academic.oup.com/ckj/article-abstract/18/8/sfaf200/8172491
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Commentary on expanded screening for primary aldosteronism in the new HTN guideline.
www.ahajournals.org/doi/10.1161/...
🔓
5 months ago
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Josh Leisring
Alex Chang, MD
5 months ago
Nice to see new AHA HTN guidelines emphasizing albuminuria detection! "[Urine ACR] (a test that assesses kidney health) is now recommended for all patients with high blood pressure. It was recommended as an optional test in the 2017 guideline."
newsroom.heart.org/news/new-hig...
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New high blood pressure guideline emphasizes prevention, early treatment to reduce CVD risk
Guideline Highlights: Nearly half of all adults in the U.S. have high blood pressure (≥130/80 mm Hg), which is the #1 preventable risk factor for cardiovascular disease, including heart attack, stroke...
https://newsroom.heart.org/news/new-high-blood-pressure-guideline-emphasizes-prevention-early-treatment-to-reduce-cvd-risk
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Josh Leisring
Jordy Cohen
5 months ago
Some key changes that stood out to me (got the opportunity to help w writing these!): 1) Stronger recs for single pill combos 2) Broader recs for screening for primary aldo (now consider in anyone with stage 2 HTN — i.e., BP >=140/90) 3) Just. Say. No… to cuffless BP devices… and to EtOH 2/
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https://No.to
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Josh Leisring
American Heart Association Journals
5 months ago
The AHA/ACC have released the 2025 High Blood Pressure Guideline, emphasizing prevention and early treatment to reduce cardiovascular disease risk. Read the Guideline in
#Hypertension
&
#Circulation
and check out our hub with commentaries and more:
www.ahajournals.org/guidelines/h...
#Cardiosky
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
6 months ago
That’s exactly our point - the Spanish data made no sense
www.nephjc.com/news/chronot...
IMO use long acting meds once a day and timing does not matter
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Chronicles of Chronotherapy in Controlling Cardiovascular Complications — NephJC
Dr Hiremath gives the chronotherapy literature a Swap.
https://www.nephjc.com/news/chronotherapy
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Josh Leisring
Alex Chang, MD
6 months ago
2025 AHA/ACC Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults 08/28/25 @ 12:00 pm – 1:30 pm CDT Featuring writing committee members and highlights from the ACC/AHA Committee on Clinical Practice Guidelines
targetbp.org/event/target...
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Target BP: Webinar – Target:BP
https://targetbp.org/event/target-bp-guideline-webinar/
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
6 months ago
We screen everyone referred to our hypertension program for many years now We don’t refer anyone to endo Most patients just need Spiro The occasional peeps need AVS and few need an adrenalectomy Confirmatory tests are useless
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Josh Leisring
Swapnil Hiremath 🍁🇨🇦
6 months ago
Indeed I suspect these guidelines are trying to shift the Overton window (did I use the phrase correctly 😎
@jordybc.bsky.social
?) - I don’t think PCPs read the JCEM! Right now even referral centres nephrologists, endocrinologists, cardiologists are doing a shitty job of screening 🤷🏽♂️
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Josh Leisring
Anand Vaidya
6 months ago
New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...
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Josh Leisring
Wanpen Vongpatanasin
6 months ago
New PA Endo guideline is also out by experts
@anandvaidya17.bsky.social
#Cardiosky
@hswapnil.medsky.social
doi.org/10.1210/clin...
loading . . .
Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline
AbstractBackground. Primary aldosteronism (PA), a primary adrenal disorder leading to excessive aldosterone production by one or both adrenal glands, is a
https://doi.org/10.1210/clinem/dgaf284
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Josh Leisring
Endocrine Society
6 months ago
Our latest clinical practice guideline, Primary Aldosteronism (
bit.ly/44MbrSv
), is now available. The new guideline recommends more widespread screening for a common hormonal cause of high blood pressure known as primary aldosteronism. Read in
@endocrinenews.bsky.social
:
bit.ly/4kFadhv
#ENDO2025
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Josh Leisring
NEJM.org
6 months ago
In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone production, and hypokalemia. Full SPARK study results:
nej.md/40Js1kz
#ENDO2025
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Josh Leisring
Rémi Goupil
6 months ago
Our new data on subclinical PA and MACE is out in Circulation! For the first time, we show that renin-independant aldosterone production is associated with an increased risk of MACE independently of BP, in people mostly normotensive with low CV risk.
www.ahajournals.org/doi/full/10....
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Josh Leisring
Mineralys Therapeutics
7 months ago
Detailed results from the pivotal P3 Launch-HTN trial were published today in
@jama.com
, reinforcing lorundrostat’s efficacy in a real-world setting. Read our press release to learn more:
ir.mineralystx.com/news-events/...
#BloodPressure
#Cardiology
#Cardiosky
#MLYS
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Josh Leisring
American Journal of Hypertension
7 months ago
#WeekendReads
blast from the past archives of
#EditorsChoice
🔗
academic.oup.com/ajh/article/...
Could renin guided therapy be cost effective? From 2013, but still very relevant?
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Josh Leisring
NEJM.org
7 months ago
How much do beta blockers help after a heart attack — even when the heart’s pumping well? The latest episode of Beyond Journal Club from
@coreimpodcast.bsky.social
& NEJM Group explores the REDUCE-AMI trial, which questions whether beta blockers are still needed for all. Listen now:
nej.md/4ekdlxX
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Should adrenalectomy still be first-line treatment of unilateral PA? ▶️adrenalectomy associates with greater decrease in LVM despite similar BP ▶️shorter duration of HTN associates with greater benefit after surgery ▶️high 24hr urine Na negatively impacts benefit of MRA
tiny.cc/jf2o001
🔒
#nephsky
7 months ago
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