#WeekendReads from the Advance Articles section Time to retire Aldosterone Suppression Testing? academic.oup.com/ajh/advance-...

Confirmatory testing (aldosterone suppression testing) for primary aldosteronism: not reliable, or reproducible, for diagnosis or predicting lateralization. Sensitivity at the expense of specificity, and vice-versa. Time to simplify the process academic.oup.com/ejendo/artic...

To accompany the new ACC/AHA BP guidelines, a practical guide on how to test for Primary Aldosteronism: now recommended for most people with hypertension. www.jacc.org/doi/10.1016/...

Adrenal insufficiency is a syndrome of cortisol deficiency. This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis. ja.ma/3HKk9Jr

Yes!

Don't miss the preprint from: @alice.soragnilab.com @michaelyehmd.bsky.social @anandvaidya17.bsky.social @nicolebechmann.bsky.social 🏥 @uthealthsa.bsky.social @dgsomucla.bsky.social @harvardmed.bsky.social @mdanderson.bsky.social @tudresden.bsky.social www.biorxiv.org/content/10.1...

🩺 In NEJM, our interactive case on a common CC - evaluation of a patient with new pulmonary symptoms www.nejm.org/doi/full/10.... Congrats to star fellow Dr Joanne I. Hsu for leading & wonderful to learn from expert multi-D colleagues @anandvaidya17.bsky.social @harvardmed.bsky.social @nejm.org

A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL

#ENDO2026 Welcomes Your Ideas | Our annual meeting will take place in Chicago, IL, June 13–16, and I’m inviting YOU to shape the program💡Submit your symposium proposal or session suggestion by Tuesday, September 2: bit.ly/4flCMjl #endocrinology @TheEndoSociety

1/ Even outside of AVS the intra-individual variability of plasma aldo is important. Another study with the same message. www.ahajournals.org/doi/10.1161/...

#ThrowbackThursday Variability of Aldosterone concentration while performing AVS academic.oup.com/ajh/article/... #Free #EditorsCHoice

Subclinical Primary Aldosteronism and MACE www.ahajournals.org/doi/10.1161/...

New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic academic.oup.com/jcem/advance...

The Impact of Modern Industrialized Dietary Sodium Intake on the Plasma Proteome academic.oup.com/ajh/advance-...

A pragmatic approach to evaluate for ADRENAL INSUFFICIENCY Thanks to @irinabancos.bsky.social and Jay Findling for lending their expertise!

Adrenal Insufficiency

Beautiful study. Stop the madness. Low-renin hypertension is by far and away some manifestation of primary aldosteronism pathophysiology. Even if you get caught up in names and definitions and can't accept this, it responds beautifully to MR antagonist therapy, so just do the right thing.

In the @annalsofim.bsky.social www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management) #NephSky #EndoSky

Work smarter, not harder! A low renin with concurrent use of ACEi/ARB is almost certainly some shade of Primary Aldosteronism. Either way, aldosterone-directed therapy is very likely to provide major clinical benefits www.ahajournals.org/eprint/TUS6C...

Do patients want to be screened for primary aldosteronism: YES How much PA can be identified with a direct-to-patient approach: A LOT Can this approach be implemented nationwide: YES @JeniferBrown www.ahajournals.org/doi/10.1161/...

Subclinical primary aldosteronism + Natriuretic peptide deficiency => HYPERTENSION academic.oup.com/jcem/advance...

Interesting study looking at a direct-to-patient approach to implement primary aldosteronism screening. www.ahajournals.org/doi/10.1161/... (paywall) @jenifermbr.bsky.social @anandvaidya17.bsky.social #medsky #nephsky

Mild autonomous #cortisol secretion in patients with aldosterone-producing adenoma and risk for cardiac remodeling and diastolic dysfunction by Cheng-Hsuan Tsai et al EJE Vol 192, Issue 1, January 2025 Full paper 👉 doi.org/10.1093/ejen... ESE Members via 👉 my.ese-hormones.org

A new interactive feature describes a 27-year-old woman who received a diagnosis of hypertension and preeclampsia. After giving birth, her blood pressure remained elevated. Test your diagnostic and therapeutic skills: nej.md/3Wsvi5L #MedSky #CardioSky #OBGYN

Interesting interactive case presentation on an under-recognized cause of hypertension. @anandvaidya17.bsky.social @nejm.org www.nejm.org/doi/10.1056/...

Primary Aldosteronism is very common This interactive case reviews how to recognize it, avoid pitfalls, and effectively help your patients @nejm.org www.nejm.org/doi/full/10.... (free access with login)

We report detailed human studies to show that a substantial proportion of normotensive people exhibit phenotypic signatures of primary aldosteronism, providing mechanistic implications for the pathogenesis of hypertension and subsequent therapy www.ahajournals.org/doi/10.1161/...

Primary aldosteronism ist the most frequent cause of secondary hypertension in young adults aged 18-40 yrs! ahajrnls.org/4fLH1Uo