Interesting molecule - Troxerutin as an osmotic agent for PD academic.oup.com/ndt/advance-... in @ndt-era.bsky.social It seems it’s a flavonol from the Japanese pagoda tree en.wikipedia.org/wiki/Troxeru... #PDSky #NephSky

A novel system to continuously estimate intradialytic blood pressure in real time More info: academic.oup.com/ndt/article/... @ndt-era.bsky.social, @hjanders.bsky.social

Should obesity remain a contraindication for a kidney transplant? www.ajkd.org/article/S027... In @ajkd.bsky.social Sure it’s a risk factor for graft failure - but so is DM, CAD - which are worse and those are not contraindications! #NephSky #Transplant

I realize folks have probably heard this elsewhere, but it looks like the shutdown will likely end very soon, if not tonight then tomorrow. The good health policy news is that the telehealth flexibilities will be extended until January 30 and made retroactive back to October 1. (1)

Community house HD continues to be a great example of patient centered care and creative thinking

In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo @asnkidney.bsky.social | #KidneyWk

a conservative dialysis strategy in possibly recovering AKI helps people recover faster! jamanetwork.com/journals/jam... in @jama.com from #KidneyWk Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?

large cohort study of CDK 4/6 BRAF EGFR VEGF and other cancer treatments #OncoNephrology #NephSky #KidneyWk jamanetwork.com/journals/jam... from Shuchi Anand et al from @stanfordmedicine.bsky.social

We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk jamanetwork.com/journals/jam...

Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself) Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵

ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL @asnkidney.bsky.social | #KidneyWk

Next up in Richard Lafayette about Ataracept in IgAN #KidneyWk

Up next a panel discussion about the trials #KidneyWk

The first-ever Home Dialysis Early Program Course is happening today at #KidneyWk2025! 🌟 Thanks to ISPD collaboration with ASN, over 100 attendees can explore the latest trends in home dialysis with great speakers from around the world. Exciting times for kidney care! 🩺#PeritonealDialysis

Ahead of #KidneyWk25, we are recruiting a hypertension fellow to the Stanford Hypertension Center for July 2026. Please come find me at ASN. med.stanford.edu/nephrology/e...

Dual-Antigen Membranous Nephropathy doi.org/10.1016/j.kint.2025.10.006 #NephSky #MedSky #membranousnephropathy @mayoclinicpath.bsky.social @arkanalabs.bsky.social @lynncornell.bsky.social @aaronstorey.bsky.social

Moving beyond N of 1 case reports! The first clinical trial of 🐷 kidneys begins N = 6, poss or expansion to 50 United Therapeutics (NYU, UAB have used this model) ca.finance.yahoo.com/news/first-c...

Patient on Automated PD presents with hypotension, abdominal pain , fever for 2 days. Symptoms developed after colonoscopy with polypectomy.

If you get a clearly pathogenic COL4A5 variant you might be able to stop after genetic testing, but a single COL4A3/4 variant doesn’t tell you what’s going on in the kidney. Still need biopsies. #NephJC

Big holes: Precedence of therapies Options when one therapy runs out (e.g. Nefecon) Lack of availability + cost of novel therapies Lack of trials for 2+ concurrent therapies Lack of apples-to-apples comparisons of therapies And I love the idea of rolling guidance updates. #NephJC

What is the global incidence of IgA nephropathy? Incidence is varied in different countries depending on urinary screening programs and timing of nephrology referral. There aren’t any validated serum markers and IgAN diagnosis is based exclusively on renal biopsy findings. #NephJC

Does China have universal urinary screening in pediatrics? I have quite a few folks who were diagnosed with IgA Nephropathy early in China before moving to the Bay Area for tech jobs #NephJC

Brush up on the @kdigo.org IgAN guidelines with this #NephGR from Prof IgA Jon Barratt youtu.be/OChs5BcTEGE?... #NephJC in a couple of hours tonight!

Check out the insightful summary by Bogdan Agavriloaei @thekidneywhisperer.bsky.social and Janany Sabescumar @glomerican.bsky.social www.nephjc.com/news/... #NephJC

Graham Abra Clinician educator and nephrologist COI: Recovering Rich Lafayette clinic fellow #NephJC

🎨Beautiful visual abstract by Dr Natalia Nombera @roxnonna23.bsky.social #NephJC www.nephjc.com/news/...

The 2025 @kdigo.org IgAN guideline quietly redraws the map: new drugs, new thresholds, and a sense that the era of “supportive care only” is finally over #Nephsky #Medsky ✍️Summary by @thekidneywhisperer.bsky.social and @glomerican.bsky.social www.nephjc.com/news/igan-kd...

There is an ongoing danish study called APPLE TREE randomizing patients who are being perscribed SGLT2i to either empa, dapa or cana. Maybe we’ll ger the answer here: lundbeckfonden.com/en/the-apple...

U-Sed Case 👨‍⚕️ 46M with uveitis + acute kidney injury (Cr 0.7 → 4.4 mg/dL) 💬 Symptoms: cough, dyspnea, vomiting, 10-kg weight loss 🧪 Urinalysis: pathologic 🩻 Kidneys: normal size 💭 Could this uveitis + AKI pattern suggest a systemic autoimmune process?

Obinituzumab aka ‘Obi’ is now FDA approved for lupus nephritis finance.yahoo.com/news/fda-app... #lupus

The opening plenary at #KidneyWk looks phenomenal Renal RCT Renaissance is upon us (LBCT list drops tomorrow) www.asn-online.org/education/ki...

As expected, Iptacopan phase 3 in IgA nephropathy slows GFR decline APPLAUSE-IgA Adding another new medication we won’t be able to access or afford to our IgA armamentarium #NephSky www.novartis.com/news/media-r...

This is pretty cool. Can't believe I hadn't heard about it before. www.kidneyregistry.com/for-donors/v...

FINE-ONE (Finerenone in albuminuric T1DM) results should be out soon/will be presented at ASN kidney week :)

I like this trial! Lead by David Cherney in Canada Sotagliflozin in T1DM and DKD kidney.ca/Research/Sup... Deliberately using a Flozin in T1DM Everyone gets CGM Everyone gets ketone monitoring #CSNHomecoming

With an interesting DKA mitigation protocol #CSNHomecoming

The 2025 #NephJC at #KidneyWk details www.nephjc.com/news/2025/10... Thanks to @jadav.bsky.social!

A startling biopsy. Severe acute TMA in a pt with suspected scleroderma renal crisis. Massive vascular thrombosis, mucoid intimal edema, and early onion skin change associated with severe cortical necrosis. #renalpath #nephsky #pathsky

Fascinating that CLYM116 is compared to sibe in a preclinical study. Hope we see more head-to-head comparisons with other leading or emerging agents!

Very strange post singling out Voclosporin and lupus nephritis from the FDA CDER chap www.linkedin.com/posts/george... since deleted already h/t @ericweinhandl.bsky.social and @grahamabra.bsky.social

And it’s live Iptacopan in C3GN makes it to @thelancet.com www.thelancet.com/journals/lan... #NephSky

A 52-year-old woman with hypertension presented to the hospital with a 1-month history of fatigue, as well as 6 days of vomiting and 1 day of confusion. Over the past 20 years, she had not received regular treatment for hypertension. 1/2 #MedSky

Small group Peritoneal Dialysis case discussion leaders at the Home Dialysis Academy of Excellence! Drs Ananthakrishnan and Young from UC Davis Division of Nephrology Dr @grahamabra.bsky.social from Stanford Division of Nephrology and Dr Harini Sarathy from UCSF Division of Nephrology

It's that time of year again 🍂🍂🍂 The #NephJC Fall pledge drive. Plese give if you are able to support our decades long mission of #FOAMed for all. #NephSky #MedSky www.nephjc.com/news/2025/9/22/nephjc-fall-pledge-drive

I teach it. I have not seen this studied in a systematic way, but Edelman equation is not just a good idea, it’s the law.

Has anyone studied the use of K supplementation to increase daily solute load and subsequently free water excretion in SIADH? #AskRenal

It’s an exciting time to be taking care of patients with Lupus Nephritis! www.healio.com/news/nephrol...

Calling @hswapnil.medsky.social 🚨 vitamin D alert 🚨