CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population academic.oup.com/ndt/article/... #nephinp #nephrology_in_practice

A must read comprehensive article @ndt-era.bsky.social focusing on the biology/genetics of kidney stone. It highlights GWASs of calcium and phosphate handling (e.g., SLC34A1, CYP24A1, CaSR) and crystallization inhibitors (e.g., UMOD, pyrophosphate-related genes). academic.oup.com/ndt/article-...

In older patients with frailty who were receiving antihypertensive drugs and had a systolic blood pressure below 130 mm Hg, reducing antihypertensive drugs did not lead to lower all-cause mortality over 4 years than usual care. Full RETREAT-FRAIL trial results and Research Summary: nej.md/45NUK9v

Sodium glucose cotransporter 2 inhibition does not improve active lupus nephritis in MRLlpr/lpr mice doi.org/10.1016/j.kint.2025.09.026 #NephSky #MedSky #lupus #nupusnephritis #kidneydisease @vhir.bsky.social @lmumuenchen.bsky.social @hjanders.bsky.social @pepasolerr.bsky.social

Now open access in @ndt-era.bsky.social Rationale, Design, and Baseline Characteristics of the TRANSCEND-CKD trial of Retatrutide in pts with CKD 🧐Retatrutide is a novel triple incretin agonist targeting GIP, GLP-1, and glucagon receptors ▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) in Chinese Pts 🧐This Chinese ADTKD cohort reveals a high prevalence of UMOD and HNF1B variants ▶️ academic.oup.com/ndt/article-...

Now online in @ndt-era.bsky.social Neutrophil infiltration of kidney grafts: incidence, associated factors and graft survival 🧐NTI should prompt the search for urinary tract infection and rejection ▶️ academic.oup.com/ndt/article-...

Now online in @ndt-era.bsky.social Recombinant alpha-1 microglobulin to improve outcomes in survivors of AKI 🧐RMC-035 may improve kidney outcomes in settings characterized by oxidative and ischemia-reperfusion injury. ▶️ academic.oup.com/ndt/article-...

🧬Complement Pathways and Regulators in Kidney Ds doi.org/10.1093/ndt/... @hjanders.bsky.social

Now open access in @ndt-era.bsky.social How can we target the production of pathogenic IgA in IgAN? 🧐Drugs directed at mucosal B cells, inhibitors of APRIL and BAFF, and drugs that target IgA-producing plasma cells ▶️https://academic.oup.com/ndt/article/doi/10.1093/ndt/gfaf185/8262262

Now online in @ndt-era.bsky.social Recombinant alpha-1 microglobulin to improve outcomes in survivors of AKI 🧐RMC-035 may improve kidney outcomes in settings characterized by oxidative and ischemia-reperfusion injury. ▶️ academic.oup.com/ndt/article-...

Now open access in @ndt-era.bsky.social Prevalence of Strongyloides stercoralis in HD pts in Vienna 🧐Implementation of targeted screening for S. stercoralis should be considered in pre-KTX protocols in Europe. ▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social QT-Prolonging Medications: Prevalence of Use and Associated Risks in CKD 🧐The pathophysiological relevance, prevalence, and CV consequences of QT-prolonging drug use in the CKD setting ▶️https://academic.oup.com/ndt/article/doi/10.1093/ndt/gfaf196/8263915

Now open access in @NDTsocial Anti-GBM disease - Treatment Standard 🧐 Anti-GBM and ANCA positive pts have a higher relapse risk and require maintenance immunosuppressive treatment ▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social Comparing CKD populations with T1D and T2D based on FINE-ONE and FIDELITY populations 🧐Similarities between populations may inform the translation of clinical evidence on finerenone from CKD and T2D to CKD and T1D. ▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social al CKD of unexplained cause (CKDx): A consensus statement by the Genes &Kidney Working Group of the ERA 🧐Check also our 2 open access editorials on this innovative concept. ▶️ academic.oup.com/ndt/article/...

Now online in @ndt-era.bsky.social Transition of pts with hereditary nephropathies from pediatric to adult care from WG Genes&Kidney of ERA and ESPN 🧐To improve health outcomes, pt empowerment, and engagement for young people with CKD. ▶️ academic.oup.com/ndt/article-...

New RCT online in @ndt-era.bsky.social Additive Effects of Oral Calcitriol on pts with IgAN receiving RAS Blockade 🧐The addition of 0.25 μg/d calcitriol to RASi safely lowered residual proteinuria and slowed eGFR decline in pts with IgAN ▶️ academic.oup.com/ndt/article-...

Now open access in @ndt-era.bsky.social Protein profiles and associated biological pathways among different etiologies of CKD: new insights from DAPA-CKD 🧐Distinct proteomic differences unravel the heterogeneous pathophysiology of human CKD. ▶️ academic.oup.com/ndt/article/...

Which agent are you using in post kidney transplant dyslipidemia? statin, ezetimibe, PCSK9 modulators or bempedoic acid? More info: academic.oup.com/ndt/article/... @ndt-era.bsky.social, @hjanders.bsky.social

Acute kidney injury, acute kidney disease and chronic kidney disease: challenges and research perspectives More info: academic.oup.com/ndt/article/... @ndt-era.bsky.social, @hjanders.bsky.social

A step toward personalized medicine More info: academic.oup.com/ndt/article/... @ndt-era.bsky.social, @hjanders.bsky.social, @Richard Glassock, @Andrew Rule, @Aleksandar Denic, @delanaye.bsky.social

Now online in @ndt-era.bsky.social Cost-effectiveness of protein restricted diets in advanced CKD 🧐In pts adherent to diet prescription, low-protein diets delay the start of dialysis, improve survival, and save money ▶️ academic.oup.com/ndt/article-...

Now open access in @ndt-era.bsky.social Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications 🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies ▶️ academic.oup.com/ndt/article/...

Now open access in @ndt-era.bsky.social What do RCTs teach us about the pathophysiology of human IgAN? 🧐B cells/PC produce the IgAN antigen GdIgA1 as well as the respective autoantibodies, hence targeting B cells/PC will be most clever. ▶️ academic.oup.com/ndt/article/...

Now online in @ndt-era.bsky.social Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease 🧐Triple-positive pts (anti-type IV collagen, -laminin 521, and -perlecan) = highest prevalence of lung hemorrhage and ESKD ▶️ academic.oup.com/ndt/article-...

Now open access in @ndt-era.bsky.social Evolving strategies for early diagnosis, proactive prevention and treatment of CKD 🧐"Inferior doctors provide KRT Mediocre doctors treat CKD Superior doctors prevent kidney disease" ▶️ academic.oup.com/ndt/article/...

Read this piece from the ERAKI working group at the @ndt-era.bsky.social regarding the results of the DEFENDER trial published last August @jama.com academic.oup.com/ndt/article/...

Now online in @ndt-era.bsky.social Acute post-streptococcal GN (in children) - treatment standard 🧐 Pathophysiology, diagnosis, outcome prediction, and management standard ▶️ academic.oup.com/ndt/article-...

Now online in @ndt-era.bsky.social Multifactorial chronic kidney disease 🧐 Life is long and our kidneys have to take many hits, hence, adult CKD is usually multifactorial as is atherosclerosis or dementia. RF control is key and RF vary across world regions ▶️ academic.oup.com/ndt/article-...

Now online in @ndt-era.bsky.social Treatment standard: CKD in the geriatric patient 🧐Pat.-centered communication about preferences and prioritized Tx goals sonsiders psychosocial factors and home environment, as well as their medical needs and prognosis ▶️ academic.oup.com/ndt/article-...

Following on CONFIDENCE (on #NephJC tomorrow) The design and baseline data from MIRO-CKD trial academic.oup.com/ndt/advance-... N = 614, balcinerone, dapagliflozin Urine ACR outcome #NephSky

T0d: #NephJC CKD’s story is shifting- RASi, flozins, MRAs, and GLP-1s have redrawn the map, turning a therapeutic desert into a landscape of cardio-renal possibility Relevant infographic from @brendonneuen.bsky.social‬ academic.oup.com/ndt...#NephJC

T0f: #NephJC CKD’s a mess—multisystemic, unpredictable, and stuck in primary care. We’ve got the evidence, the drugs, the guidelines. What don’t we have? Follow-through. Evidence doesn’t treat patients. Do people do good or bad?

The new Impact factors are out. Here is a list of some kidney journals @ndt-era.bsky.social

Ongoing discussion about UACR or UPCR in GN captured in @ndt-era.bsky.social The use of UACR or UPCR for risk prediction in IgAN url:https://academic.oup.com/ndt/article-abstract/40/1/1/7702452 UACR predicts kidney events in IgAN url:https://academic.oup.com/ndt/article/40/3/465/7660570

Now first late breaker clinical trial session at #ERA2025

Now open access in @ndt-era.bsky.social Antibody-mediated Rejection - Treatment Standard 🧐Ongoing phase 2 trials offer hope for effective, therapies targeting different aspects of AMR. academic.oup.com/ndt/article/...

Now open access in the June edition of @ndt-era.bsky.social Disease-modifying anti-nephropathic drugs (DMANDs)—a definition proposed by the IWG of ERA 🧐Not all drugs that reduce UPCR may be disease-modifying. SGLT2i are a DMAND only for GN-related CKD. academic.oup.com/ndt/article/...

🤩Call for NDT Cover Images! If you have an eye-catching image focused on kidney disease, please email it to [email protected] More info👇 academic.oup.com/ndt/pages/ca... 🤩The accepted images will be featured in the NDT Art Gallery and selected images will also appear on future covers

Effect of pharmacist interventions in chronic kidney disease: a meta-analysis doi.org/10.1093/ndt/...

Genotype-Phenotype Correlations and Clinical Outcomes of Genetic TRPC6 Podocytopathies doi.org/10.1093/ndt/... This study shows unique clinical and genetic correlations of TRPC6-AP, which may enable personalised care and promising novel therapies

Now open access in @NDT-era.bsky.social Individualizing renoprotective therapy in obese pts with CKD 👍Multitarget therapy incl. RASi, SGLT2i, GLP-1ra and nsMRAs improve MACE and MAKE in pts with overweight/obesity and T2DM ▶️https://academic.oup.com/ndt/article/doi/10.1093/ndt/gfaf069/8129710

A novel system to continuously estimate intradialytic blood pressure in real time doi.org/10.1093/ndt/...

🤩Check out the new May issue of NDT! academic.oup.com/ndt/issue

Cardiovascular involvement in ANCA-associated vasculitis doi.org/10.1093/ndt/...

An editorial in Nature calls on Member States to support a resolution that calls for the WHO to recognize kidney disease as a major cause of death and disability go.nature.com/3YQfISu

Plasma Trimethylamine N-oxide Concentration and All-Cause Mortality in Kidney Transplant Recipients doi.org/10.1093/ndt/...

Active glomerular inflammation versus chronicity and fibrosis: the role of targeted therapies in IgA nephropathy doi.org/10.1093/ndt/... 📸 Active glomerular inflammation versus chronic fibrotic phenotype in IgAN and potential therapeutic strategies

Extrarenal manifestations in inherited kidney diseases doi.org/10.1093/ndt/...