First-year over-the-counter naloxone sales showed limited uptake and did not effectively bridge gaps from pharmacy or distribution programs, likely due to high prices. ja.ma/4ogyhcJ

From 2017 to 2023, #Medicare Advantage beneficiaries saw disproportionately greater increases in hospital length of stay compared to traditional Medicare, particularly for discharges to skilled nursing facilities. ja.ma/4qSkafY

This Review explores the factors that predispose Hispanic/Latino patients to metabolic dysfunction–associated steatotic liver disease and metabolic dysfunction–associated steatohepatitis. ja.ma/3JD2ww6

JAMA Internal Medicine is looking for research on how AI is transforming patient care in areas such as clinical outcomes, diagnosis, system redesign, ethics, equity, and women’s health. 🔗 Learn more about submission criteria: ja.ma/3KJBqng

This Guide to Statistics and Methods provides an overview of the active comparator, new user design and the use of propensity score matching. ja.ma/47IsMx8

The Mighty-Heart trial found mobile integrated health offered no overall benefit over care coordination alone for #HeartFailure patients' health status or 30-day readmissions, but younger patients showed potential health improvements. ja.ma/4p0lpI9

Editor’s Note: Schwartz et al show risk-based provider contracts in Medicare Advantage do not consistently alter care use or low-value service rates. ja.ma/4qY9NYc

Voluntary transition to upside-only or 2-sided risk payment contracts in Medicare Advantage was not associated with consistent changes in health care utilization or low-value service use. ja.ma/4nJcWs6

A Singapore-based RCT found that a single mailed reminder is as effective as more complex behavioral interventions for increasing mammogram uptake among overdue repeat screeners. ja.ma/43fA9KY

Assoc. Editor Giselle Corbie, MD, MSc, and author Lynda Powell, PhD, discuss strategies for supporting lasting lifestyle changes and long-term outcomes for patients with metabolic syndrome. #AHA25 @ahascience.bsky.social 🎧 Listen now: ja.ma/3WMJTc0

In this #AHA25 edition of the JAMA Editor’s Summary podcast, Gregory Curfman, MD, Philip Greenland, MD, and Robert Bonow, MD, MS, review key JAMA Network articles, including: ➡️ Coffee and #AFib, ➡️ DASH-patterned groceries, ➡️ Oral PCSK9 inhibitor enlicitide, and more. 🎧 Listen now: ja.ma/47MpAAj

💾 Save this thread! Check out these key findings from today's JAMA, @jamacardiology.com, @jamainternalmed.com, and @jamanetworkopen.com presentations at #AHA25. 🧵 Adding coronary CT angiography to traditional risk scores modestly improved prediction of first coronary events. ja.ma/4oyzvko

A 6-month habit-based group lifestyle intervention added to routine education and activity monitoring improved the proportion of patients with sustained metabolic syndrome remission. #AHA25 @ahascience.bsky.social ja.ma/4oYXnx9

A randomized clinical trial published in JAMA found that patients with AF who consumed caffeinated coffee had a lower risk of recurrent AF or atrial flutter compared with those who abstained. #AHA25 #AFib @ahascience.bsky.social ja.ma/43UFh7x

📊 Research Summary from @jama.com: Adults with #AFib who drank at least one cup of caffeinated coffee daily after successful cardioversion had a lower risk of recurrence than those who abstained from coffee and caffeine. #AHA25 @ahascience.bsky.social ja.ma/47K8tPT

From @jama.com: Patients with #AFib who continued their usual caffeinated coffee intake after cardioversion experienced less recurrence of AF or atrial flutter compared to those who abstained from coffee and caffeine. #AHA25 @ahascience.bsky.social ja.ma/3XolIkd

#HormoneTherapy reduces vasomotor symptoms w/o increasing #cardiovascular risk in postmenopausal women aged 50 to 59, but raises cardiovascular risk in those over 70, finds this secondary analysis of 2 RCTs. ja.ma/47yoNTu

From @jama.com: Liberal transfusion after major surgery did not reduce death or major cardiac event rates compared to restrictive thresholds in high-risk patients. #AHA25 @ahascience.bsky.social ja.ma/47BjliI

From @jama.com: Among people with PAD and no #diabetes, metformin treatment for 6 months did not result in improvements in walking ability or secondary outcomes vs placebo. #AHA25 @ahascience.bsky.social ja.ma/47yiLnq

Special Communication: Doubling of early-onset cancer incidence since 1992 in US adults <50 reflects increased diagnosis; mortality remains stable or declines. ja.ma/3WDtFls

🧵 JAMA, @jamainternalmed.com, and @jamanetworkopen.com conclude #KidneyWk with impactful findings: In stable AKI patients, indication-based dialysis enabled faster liberation from dialysis and reduced health care resource use compared to conventional thrice-weekly treatment. ja.ma/4nIK3Mo

💬 @jama.com Editorial: #SGLT2 inhibitor treatment benefits extend to people with CKD and low albuminuria, as well as those with advanced #KidneyDisease, supporting wider use. #KidneyWk @asnkidney.bsky.social ja.ma/4nFSM29

From @jama.com: #SGLT2 inhibitors slow kidney decline consistently across CKD severity and albuminuria range, supporting their routine use for kidney health. #KidneyWK @asnkidney.bsky.social ja.ma/47tGDsa

From @jama.com: Among more than 800 000 CKD-PC participants, discordance between cystatin C and creatinine eGFR values was associated with increased risk of death, cardiovascular events, and kidney failure. #KidneyWK @asnkidney.bsky.social ja.ma/47uzqbn

💬 Editorial: Estrella et al show that integrated cystatin C and creatinine measurements improve CKD assessment compared to single-marker estimates. #KidneyWK ja.ma/3LxhhRy

💬 @jama.com Editorial: The LIBERATE-D trial shows conservative dialysis—guided by A-E-I-O-U indications and asking "Why"—promotes earlier kidney recovery and fewer dialysis sessions in AKI. #KidneyWK @asnkidney.bsky.social ja.ma/4hOkM1W

From @jama.com: In stable AKI patients, indication-based dialysis enabled faster liberation from dialysis and reduced health care resource use compared to conventional thrice-weekly treatment. #KidneyWK @asnkidney.bsky.social ja.ma/43Zf33H

Among Hispanic and Latino adults receiving in-center hemodialysis, a culturally tailored community health worker intervention modestly reduced interdialytic weight gain and improved adherence and patient activation compared to standard care. #KidneyWK ja.ma/49AwhYP

RCT: In postmenopausal women, elinzanetant reduced vasomotor symptoms compared to placebo at 12 weeks, with continued benefits in frequency, sleep, and quality of life over 52 weeks, while maintaining safety. ja.ma/4hH0lE8

RCT: Among 450 participants, Azelastine nasal spray was associated with a reduced incidence of lab-confirmed SARS-CoV-2 respiratory infections (2.2% compared to 6.7% with placebo). ja.ma/47ZMQMz

Venture capital investments by academic medical centers in health care companies more than doubled from 2014 to 2024, totaling $24.2 billion and supporting mostly early-stage ventures. ja.ma/47K3wGF

Liraglutide addition for Chinese patients with type 2 diabetes and minor AIS or high-risk TIA reduced 90-day stroke recurrence and improved functional outcomes. ja.ma/43NALaM

Viewpoint: #Telehealth has improved health care access for individuals experiencing homelessness by reducing barriers, although challenges like phone security and social interaction remain to be addressed. ja.ma/4oePNP3

RCT: A 12-week unsupervised online tai chi program improved knee pain and physical function in adults with osteoarthritis compared to online educational information alone. ja.ma/4qJYfrt

Viewpoint: Menopause care should extend beyond hormone therapy, emphasizing individualized care, clinician training, and evidence-based management. ja.ma/4hyjdVO

Viewpoint: The decline in life expectancy among American Indian and Alaska Native populations during the #COVID19 pandemic highlights the urgent need to address systemic health disparities. ja.ma/4hk40HO

Editor's Note: Defining obesity by clinical outcomes, not just body size, may advance care and target those at greatest health risk. ja.ma/49uKHtv

Clinical obesity, as newly defined by excess adiposity and organ dysfunction, was linked to greater all-cause and cause-specific mortality risk in the UK Biobank cohort. ja.ma/3Lekkhy

A patient in their 70s experienced muscle weakness and elevated CK due to statins, diagnosed with necrotizing autoimmune myopathy, and treated by stopping atorvastatin plus prednisone, tacrolimus, and IVIg. Learn more in this Teachable Moment: ja.ma/3J0fgfK

RCT: A 12-week unsupervised online tai chi program improved knee pain and physical function in adults with osteoarthritis compared to online educational information alone. ja.ma/47dtzqM

Updated 2024–2025 COVID-19 vaccines provided effective protection against JN.1 subvariants, with vaccine effectiveness waning over time but remaining higher for severe outcomes. ja.ma/4ocvmlL

A 31-year-old man with progressive #alopecia and symptoms indicative of secondary #syphilis, confirmed by positive Treponema pallidum testing, was diagnosed and successfully treated with #penicillin. Learn more in this Teachable Moment: ja.ma/46LPzbZ

#AED use in private homes improves survival after #CardiacArrest with shockable rhythm but does not improve outcomes for nonshockable rhythm. General AED purchase for homes is not cost-effective at current pricing. ja.ma/3Jw2tC1

Deceased donor kidney transplants offer greater survival benefits than dialysis, with the highest gains for older recipients and those receiving low-risk kidneys; benefits are limited for younger recipients and high-risk kidneys. ja.ma/3JA0Tz5

Hospice benefits in ACA Marketplace plans require substantial cost-sharing, with median deductibles of $4000 and median coinsurance of 20%, potentially impacting access for low-income enrollees. ja.ma/4qwSGwf

This case report describes a man in his 40s who presented to the emergency department with rapid wide complex tachycardia initially suspected to be ventricular tachycardia. ja.ma/438oBZP

RCT: A 12-week unsupervised online tai chi program improved knee pain and physical function in adults with osteoarthritis compared to online educational information alone. ja.ma/4hQZdy9

This Review highlights the value of discussing quality of life concerns, considering conservative management, and fostering caregiver involvement and interdisciplinary approaches for older adults. ja.ma/4qtTFgN

#AED use in private homes improves survival after #CardiacArrest with shockable rhythm but does not improve outcomes for nonshockable rhythm. General AED purchase for homes is not cost-effective at current pricing. ja.ma/43Cea0N

Editor's Note: Digital health interventions like online tai chi offer scalable, effective care for chronic conditions in motivated, connected populations. ja.ma/4hALVFO