Among adults hospitalized for community-onset #sepsis, broad-spectrum #antibiotic de-escalation at day 4 resulted in similar mortality, fewer antibiotic days, and shorter hospitalizations vs continued therapy. ja.ma/3YgnJj9

Between 2016 and 2024, #GestationalDiabetes rates at first singleton live birth significantly increased overall and across most racial and ethnic groups. ja.ma/4qtZ1I4

From @jama.com: Among patients with newly diagnosed or recent #LBP at moderate or high risk of chronicity, clinician-supported biopsychosocial self-management produced a greater proportion achieving ≥50% reduction in #disability over 12 months. ja.ma/4jezJv0

Collaborative care for opioid use disorder, depression and/or PTSD did not yield better outcomes than enhanced usual care in primary care clinics after 6 months. ja.ma/4qtpYvx

📊 @jama.com Research Summary: Spinal manipulation alone did not differ from guideline-based medical care for disability or pain in adults with increased risk for chronic low back pain. ja.ma/48WruQS

This case report describes a woman in her 60s with sequential type I Kounis syndrome and cholecystocardial syndrome, leading to dynamic, reversible electrocardiography changes mimicking acute coronary syndrome. ja.ma/3Yczya1

The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025, and did other readers agree? 🔗 ja.ma/49qQLCT

💬 Editorial: Most US adults were less comfortable with the use of income or zip code vs race when incorporated into clinical algorithms, despite increasing shifts toward race-neutral tools in #RiskPrediction. ja.ma/49rqswj

Most US adults preferred that clinicians use all available information, including race, in clinical algorithms, but discomfort was greater if race was used without explanation or when income or zip code was included. ja.ma/48RAarI

The numbers are in. The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025 -- and did other readers agree? 🔗 ja.ma/3KWyCUf

💬 Editorial: #Benzodiazepine use during #pregnancy was associated with increased risks of preterm birth, spontaneous and elective abortion, and possibly small for gestational age, though the absolute risks were low. ja.ma/4jk5piQ

#Benzodiazepine use during #pregnancy was associated with increased risks of preterm birth, spontaneous and elective abortion, and possibly small for gestational age; risk for stillbirth was not increased. ja.ma/45hUct1

Higher-valent #pneumococcal vaccines, PCV20 and PCV21, address shifting serotype patterns in adult invasive pneumococcal disease serotypes; vaccine choice depends on regional strain prevalence. ja.ma/4peMZBj

Over 4 years, nearly 1 in 6 US adults incurred out-of-pocket health care costs exceeding 10% of family income, with higher risks among those with low income, uninsurance, chronic disease, or hospitalization. ja.ma/49u6dNF

Among adults hospitalized for community-onset #sepsis, broad-spectrum #antibiotic de-escalation at day 4 resulted in similar mortality, fewer antibiotic days, and shorter hospitalizations vs continued therapy. ja.ma/4p7ffG0

Viewpoint: The Fifth Amendment ensures due process protections for acute medical care of immigration detainees; differential treatment based on custody is not justified. ja.ma/4pHWn1k

This case report describes a patient in their 50s with spontaneous chest tightness and palpitations. ja.ma/4arbAzc

This case report describes a patient in their 50s with spontaneous chest tightness and palpitations. ja.ma/4p8woil

Hospice benefits in ACA Marketplace plans require substantial cost-sharing, with median deductibles of $4000 and median coinsurance of 20%, potentially impacting access for low-income enrollees. ja.ma/4p3TPtm

Viewpoint: Physician roles will adapt as patients increasingly use #GenAI for medical research, diagnosis, and clinical interpretation. ja.ma/4aZe6wH

PREVENT risk equations identify fewer adults aged 40–59 as aspirin-eligible for primary ASCVD prevention than PCEs. ja.ma/44vBhLg

Editor's Note: Defining obesity by clinical outcomes, not just body size, may advance care and target those at greatest health risk. ja.ma/4p3XirV

Clinical obesity, as newly defined by excess adiposity and organ dysfunction, was linked to greater all-cause and cause-specific mortality risk in the UK Biobank cohort. ja.ma/44SsQd9

This Teachable Moment describes a patient in their 60s with severe alcohol use disorder and alcohol-induced cirrhosis complicated by ascites who presented with an altered mental status. ja.ma/4iV4EMI

During extreme heat days, mortality rates were higher in nursing homes without air conditioning vs those with air conditioning, supporting universal AC mandates. ja.ma/4j2SSAe

Only 4 US states comprehensively regulate IV hydration spa governance, prescriber credentials, dispensing, and compounding practices. ja.ma/3MCTJLJ

Participation in the New York State medical cannabis program was associated with a significant reduction in prescription opioid receipt over 18 months among adults with chronic pain. ja.ma/3MERmIa

Participation in the New York State medical cannabis program was associated with a significant reduction in prescription opioid receipt over 18 months among adults with chronic pain. ja.ma/4pxMAL5

Viewpoint: Menopause care should extend beyond hormone therapy, emphasizing individualized care, clinician training, and evidence-based management. ja.ma/4sc3hxJ

Criteria-independent genetic testing identified pathogenic variants in 3.1% of women without a history of #BreastCancer, including many lacking common risk factors. ja.ma/3YrE6Jy

This Teachable Moment describes a 56-year-old woman with a concern for a food allergy and bilateral leg muscle spasms. ja.ma/4oUq0eO

Criteria-independent genetic testing identified pathogenic variants in 3.1% of women without a history of #BreastCancer, including many lacking common risk factors. #SABCS25 @sabcs.bsky.social ja.ma/48OGizQ

From @jama.com: Approximately 39% of US adults met criteria for metabolic syndrome in 2023, with persistent disparities by age and race highlighting the need for ongoing preventive efforts. ja.ma/3MxUllR

Participation in the New York State medical cannabis program was associated with a significant reduction in prescription opioid receipt over 18 months among adults with chronic pain. ja.ma/48IGMsx

From @jamaophthalmology.bsky.social: Home hazards amplify fall risk for older adults with visual impairment, supporting combined vision and environmental risk assessments in prevention protocols. ja.ma/4psnL3e

Deceased donor kidney transplants offer greater survival benefits than dialysis, with the highest gains for older recipients and those receiving low-risk kidneys; benefits are limited for younger recipients and high-risk kidneys. ja.ma/4oODbh2

Viewpoint: Recent advances in cell and gene therapies provide curative treatments for rare and complex diseases, but high up-front costs create significant coverage and access challenges for US patients. ja.ma/4aH1aLI

RCT: Among adults with #LongCOVID, 28-week oral colchicine therapy did not significantly improve functional, respiratory, or mental outcomes compared to placebo, indicating colchicine is not broadly effective for long COVID. ja.ma/4po3I5T

Editor's Note: "Simple Solutions for Complex Problems" ja.ma/4ptZMAT

Original Investigation: A food subsidy led to better blood pressure control than a delivered food box among adults with hypertension and food insecurity. ja.ma/4aBal08

🎧 Listen to authors @EMrobg, MBBS, and @jasonwasfy, MD, MPhil, discuss their articles from JAMA Internal Medicine with @IlanaRichman, MD MHS. ja.ma/48V2r0n

Magnesium supplementation showed no significant impact on 24-hour risk of tachyarrhythmias, hypotension or death in critically ill patients with hypomagnesemia with serum values close to hospital thresholds. ja.ma/44KJUBu

The FDA Amendments Act was associated with faster postmarket safety actions within 5 years of approval, but not with overall differences in time to first safety-related action. ja.ma/4qfFeMz

Participation in the New York State medical cannabis program was associated with a significant reduction in prescription opioid receipt over 18 months among adults with chronic pain. ja.ma/48ksr5g

Artificial intelligence, if implemented thoughtfully and equitably, could unlock a more precise understanding of women’s health. Learn more in this Editorial. ja.ma/3YbEk7y

Original Investigation: A slow-tempo music intervention did not reduce delirium duration, severity, pain, or anxiety in mechanically ventilated older adults in the ICU. ja.ma/4rjeADv

This JAMA Internal Medicine Patient Page describes dense breasts and whether they might lead to higher risk for #BreastCancer. ja.ma/4oD3CXc

Updated 2024–2025 COVID-19 vaccines provided effective protection against JN.1 subvariants, with vaccine effectiveness waning over time but remaining higher for severe outcomes. ja.ma/3KInyd7

The review highlights the value of discussing quality of life concerns, considering conservative management, and fostering caregiver involvement and interdisciplinary approaches for older adults. ja.ma/4pPRLGf

"The Editors of JAMA Internal Medicine are excited to invite the scientific community to contribute studies that will help shape the future of AI in medical and health care research, policy, and practice." Learn more in this Editorial. ja.ma/4p5P2Zf