Chronotherapy in the news again? @medscape.com discusses the story so far with the new ONAM study www.medscape.com/viewarticle/... @drlabos.bsky.social feat Scott Garrison and moi #Hypertension

Hypertension Secrets has been translated into multiple languages, including Lithuanian! Get your copy here: shop.elsevier.com/books/hypert... @edgarvlermamd.bsky.social @drjmluther.bsky.social

The CPC from last @ahascience.bsky.social #HypertensionSessions now published in @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/... thanks to @drjmluther.bsky.social and all the education editors for the invite We hope it makes for an educational read!

New 2025 AHA/ACC Hypertension Guideline dropped! www.jacc.org/doi/10.1016/... #hypertension #medsky #nephsky

#LaskerLaureate Rustom Jal Vakil was born #OTD in 1911. He won a #LaskerAward in 1957 for his studies on the use of reserpine in the treatment of #hypertension. ow.ly/bFTR50FunRI 🧪

New PA Endo guideline is also out by experts @anandvaidya17.bsky.social #Cardiosky @hswapnil.medsky.social doi.org/10.1210/clin...

The first #ERA25 simultaneous pub CONFIDENCE trial of empagliflozin + finerenone in N = 579 Greater reduction in ACR and BP Note the impressive GFR dip www.nejm.org/doi/full/10....

Plenary at @hypertensioncanada.bsky.social with @drjmluther.bsky.social on new drugs He starts of with the really old drugs! #CHC25

Phase 2 trial of the new antihypertensive agent, ultra-long-acting (q6 month), subq, small interfering RNA against angiotensinogen (Zilebesiran), hit JAMA! h/t @drjmluther.bsky.social jamanetwork.com/journals/jam... 1/

Matt Luther, Nephrologist/HTN specialist COI: Mineralys consulting #NephJC

Today we presented detailed results from our pivotal Ph3 Launch-HTN trial at #ESH2025, reinforcing the promise of lorundrostat as a new treatment approach for aldosterone driven #hypertension. Read our press release to learn more: ir.mineralystx.com/news-events/... $MLYS #bloodpressure

There you have it: BEDMED published in @jama.com jamanetwork.com/journals/jam... h/t @drjmluther.bsky.social No difference in bedtime versus morning BP meds - as expected #NephSky #Hypertension 1/

Aaand it’s official, we have a new antihypertensive class!!!! 🎉🍾🎊 I like this RCT design in particular because it was open to both uncontrolled not-yet-resistant AND resistant hypertensive patients, opening to door to prescribe it as an earlier line agent www.nejm.org/doi/full/10....

The ASIs have arrived www.nejm.org/doi/full/10.... Aldosterone synthase inhibitors - first one to finish the phase 3 line #Lorundrostat #Hypertension

How often have you seen Ferric Carboxymaltose cause hypophosphatemia? @kidneyboy.bsky.social @hswapnil.medsky.social @askrenal.bsky.social #askrenal pubmed.ncbi.nlm.nih.gov/39659775/

Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization bit.ly/3CEO9n1 #OpenAccess

We showed a dramatic difference (dramatic for a small sample size!) in the effect of CTD vs HCTZ on urine calcium. That's my preference for stone prevention. RCT with stone outcome needed. pubmed.ncbi.nlm.nih.gov/40194294/

Retatrutide (GLP, GIP, Glucagon receptor agonist) and albuminuria and GFR changes from phase 2 trial now in @kireports.bsky.social Two Ph2 trials, one in T2DM and another in Obesity with about N ~ 300 each uACR reduced in both RCTs (A, B) Much more pronounced when baseline > 30 mg/g (C, D) 1/

Wait it's wilder. Always check the appendix. They broke down BP reductions by >140 or <140 systolic & >90 or <90 diastolic. Those with HTN saw average reductions of 30mmhg systolic & 15mmHg diastolic for obese patients & 20/10 for diabetics. 🤯🤯 Also 41% of pts stopped one BP med on 12mg dose

behold the CONNECTED SPLATTERPIE kneel before my works, ye mighty, and despair

Great pearls by @jbrianbyrd.bsky.social in evaluating pts for RDN at #ACC25: 1. confirm uncontrolled HTN with out of office measure (Amb BP monitor); 2. trial spironolactone 1st; 3. shared decision making key - care team should include HTN specialists beyond those performing the procedure #cardiosky

From @spjuraschek.bsky.social et al in the @bmj.com www.bmj.com/content/388/... Orthostatic #hypertension seems bad, but lowering BP intensively also lowers this #NephSky

Chloride depletion alkalosis (as opposed to what was previously called 'contraction alkalosis') #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/22223876/

🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]

Our #rFSGS biobank is growing and we welcome patients from all over the world! Please reach out to us if you are a patient or a physician caring for one. We are creating a resource for everyone to use with the goal of resolving this disease and find new cures. #KidneyMonth2025 #RareDisease #genetics

#Quiz: A man in his 40s with untreated hypertension presented with right-sided neurologic deficits and slurred speech. His hypertension & age prompted investigation for a secondary etiology of his hypertension. What is the differential diagnosis? bit.ly/3gyO2ie (FREE)

Bladder Symptoms Provoked by Short, Rapid-Acting Loop Diuretics: A Frequent but Often Overlooked Problem academic.oup.com/ajh/article/... Dr. Wilcox and colleagues @gumedcenter.bsky.social

Dolly Parton's husband, Carl Dean, died on Monday. On Friday at midnight, Parton released the song "If You Hadn't Been There" in his memory.

DASH diet with low sodium lowers BP in DM, even when sglt2-i or glp-1 agonists are used! #epilifestyle25

me [watching RFK jr bite the head off a freshly killed gila monster]: huh are you doing that for like natural glp-1? RFK jr: for what now?

Genetic regulation of plasma sodium concentration is variable and pathways involving the pituitary gland have an important role. There is no evidence of genetic predisposition for the plasma sodium-lowering effect of thiazides. bit.ly/JASN0622 #ASNJASN #BasicResearch

Very interesting regions indeed ajkdblog.org/2025/03/01/w... #NephMadness #BlueRibbonFail incoming

I joined Endocrine Society to request a copy. Turns out it is an open link to a surveymonkey site. I checked and they said it was ok to share. Please share your thoughts! www.surveymonkey.com/r/endopacpg

Primary Aldosteronism Guideline Now Available for Open Comment | Society members are invited to review and provide feedback for our new development of a new guideline, which was provided to them via email. The comment period will close on Tuesday, March 4. #aldosteronism #endocrinology #EndoSky

Do you know why Bluesky limits you to 4 images? Because that is enough to get the entire manuscript by O Müller-Plathe in a single post pubmed.ncbi.nlm.nih.gov/3126258/ This is the reference from Chapter 17 of Burton Rose

Check out the latest Channel Your Enthusiasm Podcast 🎧 covering Chapter 17: Introduction to Simple and Mixed Acid Base Disorders #Nephpearls This discussion brings back memories of the Davenport Diagram 🧪 👉🏼 www.rosebook.club/episodes/202...

Mild autonomous #cortisol secretion in patients with aldosterone-producing adenoma and risk for cardiac remodeling and diastolic dysfunction by Cheng-Hsuan Tsai et al EJE Vol 192, Issue 1, January 2025 Full paper 👉 doi.org/10.1093/ejen... ESE Members via 👉 my.ese-hormones.org

8:42 pm, Just to give an idea of ETAs, if the storm crossing the TN River keeps its current speed, it would get to Davidson Co about 10pm. I'd be where you're gonna be by 9:30 ish.

Save the Date!, 👀🤓🙌🙏💛 May 29-30, 2025! Hypertension Canada (virtual) conference! Link to register: hypertension.ca/2025-virtual... 2025 #Hypertension Canada clinical guidelines led by Dr. Hundemer & Dr. @goupilremi.bsky.social + soo coool that Dr. @drjmluther.bsky.social will be presenting!🤓🙏

Moving defense of childhood #vaccines by Vanderbilt vaccine expert Kathy Edwards in JAMA. Stunning that so many people fear the tools that prevent children from dying and being maimed, rather than the pathogens that resurge when vaccine use declines. jamanetwork.com/journals/jam...

THE MERITS OF OUR COCAINE - a pharmaceutical advert from 1907. A "first-class, thoroughly reliable preparation" that has "been fully recognized by the majority of physicians, surgeons and chemists."

Thick skin and thicker arteries: case report on a rare cause of hypertension link.springer.com/article/10.1... #hypertension #nephsky

New in the January 30, 2025, issue of NEJM: Tirzepatide for Heart Failure and Obesity (SUMMIT trial) nej.md/4hRGaTY Continuation of Oral Anticoagulation during TAVI (POPular PAUSE TAVI trial) nej.md/3XllHys Lentiviral Gene Therapy for Hemophilia A nej.md/3Vk5xUA #MedSky

Effect of Dual RAAS Blockade and Intensive BP Lowering on Risk of ESKD and Death in ADPKD: Long-Term Follow-Up of the HALT-PKD Trials https://bit.ly/4g6t82A (FREE)

"Why study genetic diseases when you cannot treat them?" We've seen these comments from grants' reviewers way too many times Wrong! Genetics offers a myriad of possibilities for targeted treatments: here is one and it's happening now! @asnpublications.bsky.social journals.lww.com/jasn/fulltex...

This should make my pharmacist's job a little easier to get approval.

Welcome, newbies! “One Night Cough Syrup” from the 1930s contained cannabis, morphine, chloroform, & alcohol. In 1934, the FDA ruled that claims of the cough syrup's therapeutic properties were misleading. Remaining stock was destroyed. Enjoy medical history? Come along and join me!

In the present discussions about NIH and the need for reform, two recurring points I am seeing are: (1) NIH doesn't fund truly high impact research (2) NIH needs to experiment with alternative approaches to peer review, particularly for high risk-high impact research 1/n