We are happy to post 🦓 🐟 updates if you want to write them! (Or broadly: a basic science progress at #KidneyWk blog)

Summary from the #NephJC team of day 3 www.nephjc.com/news/2025/11... Since we had only two trials simul-published today at #KidneyWk we took some creative license on what to include ! @nephroseeker.medsky.social with the beautiful graphics and tables apart from the lion’s share of writing!

Pediatric renalism - it’s little bit worse than just renalism see below #Kidneywk #NephSky

This is not an acceptable status quo. Children with kidney disease are being left behind. #KidneyWk

Late breakers that included children: ✅Setanaxib in Alport (12+) Late breakers that did NOT include children: 🚫Atacicept in IgAN 🚫CONFIDENCE 🚫PISCES: Fish oil in Dialysis 🚫LIBERATE-D 🚫balcinrenone + dapa 🚫Obintuzumab in lupus nephritis 🚫Sibeprenlimab in IgA 🚫MIL62 in membranous +more #KidneyWk

Missing all the overwhelming amount of science coming out of #KidneyWk? The #NephJC crew has got you covered Day 2 edition www.nephjc.com/news/kidneyw... via @nephroseeker.medsky.social & moi

And another ns-MRA Balcinrenone added to Dapa in proteinuric CKD #KidneyWK @thelancet.com www.thelancet.com/journals/lan...

A synthetic cocktail of llama and alpaca nanobodies protected mice from the venom of 17 snakes. www.science.org/content/arti...

Former head of the US Food and Drug Administration and distinguished cardiovascular medicine researcher Robert M. Califf, MD, will receive the ASN President's Medal on Saturday, November 8. Read more about the award and awardee in #ASNKidneyNews: kidney.pub/KN1710-51#ASNKidneyNews:

Got #KidneyWk FOMO like @nephroseeker.medsky.social ? We got you covered with daily coverage of the simultaneous publications! www.nephjc.com/news/kidneyw...

The 4 pillars of CKD management: RAASi SGLT2i MRA GLP-1 agonists #KidneyWk Dr Perkovic calls for combination therapy, but need properly run trials.

ICYMI: the #PEI Renal Program has implemented home hemodialysis services in collaboration with the @uhn.ca www.cbc.ca/news/canada/... Now, all provinces in Canada provide home hemodialysis services, 🤓😀 #NephSky

Oral hygiene has been linked to multiple health conditions, including dementia and diabetes. Now, research shows that people with both gum disease and more tooth cavities also have a notably higher risk of stroke. www.sciencealert.com/21-year-stud...

Walking a few thousand steps a day can slow cognitive decline in older adults who are at increased risk of developing Alzheimer’s disease, according to new research.

#NephJC at #KidneyWk 🔥🔥We have all sorts of events 🗓️ Friday, a classic: #NephJC night- #NephJCKidney Awards, @freelyfiltered.bsky.social live recording + lots of fun 🗓️ Saturday, Nov 8th, 6:30 am- will start the day with a nephro run 🏃🏃 For more info 👇👇 www.nephjc.com

Forgot to post the two at plenary on Thursday FINEONE: finerenone in T1DM ORIGIN: Atacicept (pronounced attack-e-sept) in IgAN (pronounced eye-gee-A-N) Possible NEJM or Lancet simulpubs? #KidneyWk

#Polygenic Risk Scores Predicting Estimated #GFR Validated With #Iohexol Clearance #VIsualAbstract by Brian Rifkin https://www.kireports.org/article/S2468-0249(25)00660-6/fulltext

Ahead of #KidneyWk25, we are recruiting a hypertension fellow to the Stanford Hypertension Center for July 2026. Please come find me at ASN. med.stanford.edu/nephrology/e...

Apols here it is journals.sagepub.com/doi/abs/10.1...

🩺 New paper out in The Journal of Vascular Access: “Mapping national variation in #hemodialysis #CVC management: A UK-wide survey.” 🔗 doi.org/10.1177/1129... One of the commonest procedures in renal care — central venous catheter insertion — yet still no national standard for how it’s done.

Another Cochrane review #Obesity “The effects of semaglutide on quality of life, MACE, and mortality are likely limited or uncertain” www.cochranelibrary.com/cdsr/doi/10....

Read about the approach taken in the latest Canadian #hypertension guidelines, in an article from Gregory Hundemer, Ross Tsuyuki and Remi Goupil. The article is published in the latest edition of Hypertension News. Read today: ish-world.com/ish-hyperten...

The most important thing to realize about the Blue Jays-Dodgers World series is that the Yankees suck

Excellent #NephMadness post on the Salmon here ajkdblog.org/2018/03/15/n... by @maximalchange.bsky.social

C’mon - hydration really? @nytgames.bsky.social You know what pure hydration during running gives you? Hyponatremia #NephSky

Freely Filtered dives into ACHIEVE with Mike Walsh. This was a great episode. Also with show notes, chapters, and key images (if your podcast client supports it) www.nephjc.com/freelyfilter...

EDITORIAL by Pascale Khairallah, Elizabeth Lorenz, and Puneet Sood: Rethinking Transplant Care Through a Sex- and Gender-Based Lens bit.ly/433XPly (FREE)

Looks like he’s gone www.nytimes.com/2025/11/02/h... Strange times when a chap accuses VP of approving new drugs to quickly with surrogate outcomes 😏

woot!, grrreat, exciting game!!, 😃🙏 Mookie Betts, former #BoSox player, is now a 4X World Series Champion!!, #Excellence 😃🙏💛

I made this video 2 years ago. I had a lot of people tell me I was being dramatic. Now we know UNH are pushing nursing home to get residents to sign DNRs. I’m so glad people are waking up. youtube.com/shorts/ZZtHN...

People do this in healthcare and it always irritates me. “Look at that patient. They sit there with an iPhone but say they can’t afford their medications?” Buddy, you are mad at the wrong thing.

Have a renal friendly Halloween!, 🤓😃🙏💛 #NephSky Another timeless Dr. @glaucomflecken.bsky.social classic, 😃🙏💛 youtu.be/IAghdVqVJUg?...

What we do (and don’t know) about autism and aging – new research theconversation.com/what-we-do-a... #autism #aging #Alzheimers #dementia #gerontology #geriatrics #GeriSky #GeronSky

#Alzeimer disease is more common in women than men. Often attributed to the fact that women tend to live longer, research shows the sex gap likely stems from a complex mix of biological and sociocultural factors. ja.ma/47fkQEw

ICYMI: this is what all the kids are listening to these days, 🤓😃😂 “I love ketone bodies.” youtu.be/_xhZUCCK-UY?...

The BICAR-ICU-2 trial just dropped! RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia VERY similar conclusions to BICAR-ICU-1 🧵 #1/ jamanetwork.com/journals/jam... #EMIMCC

New KDIGO Conversations in Nephrology series on #IgAN! Hosted by Dana Rizk, experts share key takeaways from the new KDIGO IgAN Guideline. In Ep. 24, Brad Rovin shares key guideline updates. In Ep. 25, Shikha Wadhwani discusses the IgAN treatment revolution. Listen now: kdigo.co/Conversation...

Unfortunately no pediatric data yet on newer therapies. Sparsentan and finenerone trials underway. Budesonide never studied in children with IgAN. SGTL2i never studied in children with kidney diseases (both compounds given exemptions from FDA and EMEA).

Treatment Approach: 💊 Novel therapies for IgAN have shifted the paradigm to a bi-pronged approach. a) Generic responses to HTN/proteinuria b) Fundamental drivers of nephron loss by reducing the formation of aberrant IgA molecules & the maladaptive mechanisms that contribute to CKD. #NephJC

Don’t forget to support #FOAMed and #NephJC with our annual fundraiser. Every donation helps keep us going (even as unpaid volunteers). 🫶🫶🫶 www.nephjc.com#FOAMed

I want an update in 6 months. And I want some apples-to-apples comparisons of anti-APRIL w/anti-APRIL+anti-BAFF. #NephJC

Areas of future research: 💉🩺 Though we have learnt a lot on IgA Nephropathy today, still incomplete knowledge of many grey areas to be answered. What do you want to know more about IgAN in the next update (2 years)? #NephJC

2 years? I think we need a plan for a 2 week update! Should we have continuously updated recs based on when new evidence comes out? I think NCCN cancer guidelines are like this #nephjc

Yes, it’s the the guideline got an upgrade and it’s already old 😭 #NephJC

If you want to stay on top of #NephJC happenings, sign up for our once a week newsletter 📰 📢 www.nephjc.com/newsl...#NephJC

31 wasn't ideal. Before that it'd been under 60 since 2019. So at what point should a PCP refer? #NephJC

Special situations: IgA with Nephrotic syndrome: presentation is rare but associated with podocytopathy. Treat according to the histological pattern and clinical presentation. With the impending approval of DEARAs for FSGS, should it be first line in these patients? #NephJC

The recent guidelines are evolving as a ray of hope in the evidence-based treatment of IgA Nephropathy, but the trials are conducted only in few countries and lack of data from the countries where the disease is more prevalent like India, questions the generalizability of these trials. #NephJC

Special situations: IgA with AKI 🆘: AKI may occur during episodes of gross hematuria, usually improves after control of hematuria. Sometimes RPGN masquerades as AKI, so act early and have a low threshold for renal biopsy if there is uncertainty. #NephJC

IgA nephropathy & pregnancy 🤰🩺 #NephJC IgAN is common in young females. 👶Fetotoxic meds - RASi, sparsentan, Nefecon, SGLT2i, systemic steroids, prior to conception. 👶Alternatives for HTN 👶Steroids in1st trimester has the risk of cleftlip/cleft palate. 👶Nefecon is class C.