#RenalPath: Diffuse granular capillary wall staining for phospholipase A2 receptor (PLA2R). PLA2R staining is positive in approximately 70% of patients with clinically idiopathic membranous nephropathy (immunofluorescence microscopy, PLA2R). bit.ly/2xVkJzs (FREE)

Heard that Twitter is imploding. Good riddance

@hswapnil.medsky.social @kidneyboy.bsky.social What’s the name of the nephrology song you play at the end of the podcast?

The second sibeprenlimab paper in @nejm.org (At least we gave it an oral at #KidneyWk unlike the poster for the phase 2 data in 2023!) www.nejm.org/doi/full/10....

And it’s live Iptacopan in C3GN makes it to @thelancet.com www.thelancet.com/journals/lan... #NephSky

Amazing to me that a seemingly acute event is either A) has long-term sequellae despite being apparently resolving or B) a dramatic and early presentation of profound endothelial disease

Way scarier story. Stories. www.nytimes.com/2025/06/13/t... (Gift link)

Sibeprenlimab in IgA Nephropathy #ERA25 * Data presented is the 9-month reduction in proteinuria

Dr Meghan Sise presenting on serum cr/cystatin outcomes in patients treated with cisplatin or carboplatin #Onconeph #ERA25

Hyperkalemia rates not lower with adding a flozin to the MRA 🤔 www.nejm.org/doi/full/10.... #ERA25

The first #ERA25 simultaneous pub CONFIDENCE trial of empagliflozin + finerenone in N = 579 Greater reduction in ACR and BP Note the impressive GFR dip www.nejm.org/doi/full/10....

In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results: nej.md/4jEVbbk #ERA25 #MedSky #Nephrology

@kevinyau.bsky.social GLP1 agonist master Jedi presenting at #ERA25. 💉GLP1 agonist reduce ED visits and hospitalizations!!! 📉Awesome methods. Best of the session: 💊DDP4 for comparison, IPTW, ICES data. Ticking all the right boxes (EPI nerd). 💊Only 40% on SGLT2i!!! We should flozinate more!!!

#ERA25 baby!!!

Experiential Evidence of Systemic Racism for Indigenous Peoples Navigating Transplantation in Canada - in @kireports.bsky.social www.kireports.org/article/S246... #NephSky

The US spends billions of dollars on binders every year We are doing the RCT to get you the answer - more than 3000 enrolled ajkdblog.org/2021/06/16/c... and www.nephjc.com/news/2021/2/...

Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. This study found no meaningful pharmacokinetic/pharmacodynamic advantages for torsemide versus furosemide. bit.ly/JASN0481

Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production #Nephrology #endocrinology #Diabetes #SGLT2i #NephSky www.tandfonline.com/doi/full/10....

Case report: Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report https://buff.ly/3P5dsSc

Feliz Navidad!

💡 Kidney stone patients not meeting their fluid intake goals? Try this one weird trick! Sprinkle a little Carolina reaper powder on their food a couple times a day and 💦🆙 they'll be drinking so much water you'll be looking up the latest #NephJC on hyponatremia correction rates! GI docs hate him!

Cumulative Blood Pressure Load and Incident CKD https://bit.ly/4eEtmx7 #OpenAccess #VisualAbstract

Nope we use the patients usual dwell volume

Is there any preferred dwell volume for IP antibiotics? @pd-perls.bsky.social #askrenal #nephsky

Prevent kidney failure to reduce carbon emissions ♻️ 🍃 🏭 Our new analysis of CREDENCE assessing environmental impacts from ⬇️ hospitalisations & dialysis 🏥 with SGLT2i SGLT2i ⬇️ greenhouse gas emissions from inpatient bed days & dialysis by 20% (39 kg CO2e per yr) www.thelancet.com/journals/lan...

Kidney biopsy on aspirin, nay or yay? I am interested in your type 1, blink of an eye, kind of reasoning. Is Dr Glassock yet in Blue Sky? #askrenal #nephsky @kidneyboy.bsky.social

💊 Hydralazine (Hz) was first introduced to the market in 1951. The first case of Hz autoimmunity was in 1953, and the first series of Hz induced ANCA vasculitis overlapping with lupus was in 1984! But, who is really at high risk and what are the outcomes? #nephsky #nephtwitter

Deleting X account today. #bluesky all the way

23 million

Reposting (fixed link): Check out our new and improved KFRE calculator with a nice visualization of kidney risk plotted on a KDIGO heatmap. For easy reference, go to ukidney.com/kfre ✨ New features: • Interactive KDIGO heatmap • Clear risk visualization

Ever need help converting between different steroid doses or different immunosuppressive agents in transplant? • Envarsus to Cyclosporine IV? • Astagraf/Advagraf to Envarsus? • Prednisone to Solucortef? • And many more? We have you covered! ukid.io/drugs

Others have noted it but I will too: The big reason Bluesky is so hot right now is that the people who add value to social media - the frequent posters in specific fields - are here now, talking to each other and creating the "spectator value" that draws users and attention.

🦋will hit 22 million users tonight 🐦 & 🧵 have many magnitudes more users But it’s the quality and not the quantity of users that gives BlueSky the edge, says @jaypeters.net at @theverge.com www.theverge.com/2024/11/23/2... h/t @kidneyboy.bsky.social via @scalzi.com

Just finished a smooth migration of prior X tweets to @bsky.app. Shout-out to @marcomaroni.it for the excellent code! 🔥https://github.com/marcomaroni-github/twitter-to-bluesky #NephSky #MedSky #NewHorizons

How do we feel about this study (DAPA advKD)? www.medscape.com/viewarticle/... Does it answer the Q of initiating SGLT2-I in adv CKD? Are the numbers enough? #nephsky @kidneyboy.bsky.social @hswapnil.bsky.social @freelyfiltered.bsky.social Maybe another one that could be discussed..

I hope that people who took an Ancestry or a 23&Me or simply had a relative who was sequenced for their cancer treatment understand they are one hack away from them and their facilities before they become uninsurable or unemployable once #GINA is revoked along with the ACA.

Hot take for #nephsky. I dislike the common use AKI for anyone with an elevated creatinine. Neither volume contraction nor obstruction cause significant injury. I find this use decreases thinking.

‘A place of joy’: why scientists are joining the rush to Bluesky @natureportfolio.bsky.social #NephSky #MedSky www.nature.com/articles/d41...

Just saw 2 ICU hyperNa cases, so here's a #medsky #nephsky🧵 on why... 🤨 Out: Solute-free H2O clearance 😎 In: Electrolyte-free H2O clearance 🫘 1st was recovering from AKI -->⬆️ filtered urea load as the BUN ⬇️ 🥩 2nd was receiving very high protein tube feeds -->⬆️ filtered urea load with stable BUN

The feed is still too slow for the live #nephjc chat, but seems to collect all the posts in discussion threads nicely. Looks great for following up after the chat! bsky.app/profile/did:...

I think this feed works well. It is based on the label. bsky.app/profile/did:...

Glomerular disease combined with case-based teaching? Count me in! 😄 It's my favorite part of @ajkd.bsky.social Check out this fascinating GN case here: ajkd.org/article/S0272-…

Hello, Blue Sky! I’m a kiwi Rheumatologist, educator, tech enthusiast with a global outlook, exploring health, resilience & science. Let’s make waves under clear skies!

🌍 Don’t forget to sign the @ISNkidneycare petition urging @WHO to prioritize kidney disease. Also, check out @hswapnil's insightful review! Every signature counts—let's go for the cause! #NephJC www.nephjc.com/news/isn-who...

A side point: classic RCTs in dialysis have problems with enrollment- RENAL AF, AXADIA-AFNET 8- even CONVINCE Maybe the solution is to design master trial protocols?- which cut costs, solve some of the generalizability issues (e.g. geographical distributions) #nephjc www.nephjc.com/news/master-...

Bluesky now has over 20M people!! 🎉 We've been adding over a million users per day for the last few days. To celebrate, here are 20 fun facts about Bluesky:

I used @en.blueark.app to transfer tweetorials previously posted on Twitter here to @bsky.app. Very fair price and quick process. If you do the same, note my previous comments, particularly regarding links and search.

Wondering why vasoconstrictors work in hepatorenal syndrome even though the pathogenesis is driven by renal vasoconstriction? Here is a conceptual explanation: