Alex Meraz
@nephroguy.bsky.social
📤 664
📥 290
📝 55
Academic Nephrologist in Winnipeg 🇨🇦. Onconeph and Critical care neph FTW!
Heard that Twitter is imploding. Good riddance
about 10 hours ago
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@hswapnil.medsky.social
@kidneyboy.bsky.social
What’s the name of the nephrology song you play at the end of the podcast?
15 days ago
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Alex Meraz
Swapnil Hiremath 🍁🇨🇦
20 days ago
The second sibeprenlimab paper in
@nejm.org
(At least we gave it an oral at
#KidneyWk
unlike the poster for the phase 2 data in 2023!)
www.nejm.org/doi/full/10....
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Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial | NEJM
The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and...
https://www.nejm.org/doi/full/10.1056/NEJMoa2512133?query=RP&ssotoken=U2FsdGVkX18HwtSgXglJ1gbcCroISBKK7yPln43pSCZV8yPfQWUatNAzAHDZBaHCcgLB1ey0WaqsHwg9PzlzebfiBSX0qqNhK5vqLkva1kwLqzfHXq6r3A1Q2ZJqPOKnmHuZ7VTxPnkrt%2FDjX5BImxr3NHKvBalst0pzallnX5zWjaTtwNLPxgJ7wITboUre4GGzki3ZPnqTE%2BULAIOe5mWs5ItpHCKC8AWsoKuDhtE%3D&cid=NEJM%20Recently%20Published,%20November%208,%202025%20DM2425300_NEJM_Non_Subscriber&bid=-1078256474
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Alex Meraz
Swapnil Hiremath 🍁🇨🇦
2 months ago
And it’s live Iptacopan in C3GN makes it to
@thelancet.com
www.thelancet.com/journals/lan...
#NephSky
add a skeleton here at some point
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Alex Meraz
Joel Topf
5 months ago
Amazing to me that a seemingly acute event is either A) has long-term sequellae despite being apparently resolving or B) a dramatic and early presentation of profound endothelial disease
add a skeleton here at some point
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Alex Meraz
Swapnil Hiremath 🍁🇨🇦
6 months ago
Way scarier story. Stories.
www.nytimes.com/2025/06/13/t...
(Gift link)
add a skeleton here at some point
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Alex Meraz
Hugo Diniz, MD 🇵🇹🇪🇺
6 months ago
Sibeprenlimab in IgA Nephropathy
#ERA25
* Data presented is the 9-month reduction in proteinuria
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Dr Meghan Sise presenting on serum cr/cystatin outcomes in patients treated with cisplatin or carboplatin
#Onconeph
#ERA25
6 months ago
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Alex Meraz
Swapnil Hiremath 🍁🇨🇦
6 months ago
Hyperkalemia rates not lower with adding a flozin to the MRA 🤔
www.nejm.org/doi/full/10....
#ERA25
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Alex Meraz
Swapnil Hiremath 🍁🇨🇦
6 months ago
The first
#ERA25
simultaneous pub CONFIDENCE trial of empagliflozin + finerenone in N = 579 Greater reduction in ACR and BP Note the impressive GFR dip
www.nejm.org/doi/full/10....
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Alex Meraz
NEJM.org
6 months ago
In the CONFIDENCE trial in persons with chronic kidney disease and type 2 diabetes, combination therapy with finerenone and empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either drug alone. Full trial results:
nej.md/4jEVbbk
#ERA25
#MedSky
#Nephrology
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@kevinyau.bsky.social
GLP1 agonist master Jedi presenting at
#ERA25
. 💉GLP1 agonist reduce ED visits and hospitalizations!!! 📉Awesome methods. Best of the session: 💊DDP4 for comparison, IPTW, ICES data. Ticking all the right boxes (EPI nerd). 💊Only 40% on SGLT2i!!! We should flozinate more!!!
6 months ago
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#ERA25
baby!!!
6 months ago
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Alex Meraz
Swapnil Hiremath 🍁🇨🇦
6 months ago
Experiential Evidence of Systemic Racism for Indigenous Peoples Navigating Transplantation in Canada - in
@kireports.bsky.social
www.kireports.org/article/S246...
#NephSky
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Alex Meraz
Swapnil Hiremath 🍁🇨🇦
6 months ago
The US spends billions of dollars on binders every year We are doing the RCT to get you the answer - more than 3000 enrolled
ajkdblog.org/2021/06/16/c...
and
www.nephjc.com/news/2021/2/...
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Could High Be Better Than Low? Targeting Phosphate in Trials
Phosphate is bad, right? As kidney function declines, phosphate excretion goes down. Serum phosphate levels rise, causing parathyroid hormone (PTH) to increase and bring phosphate down. Phosphate h…
https://ajkdblog.org/2021/06/16/could-high-be-better-than-low-targeting-phosphate-in-trials/
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Alex Meraz
ASN Publications
11 months ago
Torsemide is proposed to have clinically important pharmacokinetic and pharmacodynamic advantages over furosemide. This study found no meaningful pharmacokinetic/pharmacodynamic advantages for torsemide versus furosemide.
bit.ly/JASN0481
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Alex Meraz
Renal Failure
11 months ago
Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production
#Nephrology
#endocrinology
#Diabetes
#SGLT2i
#NephSky
www.tandfonline.com/doi/full/10....
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Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Sodium-glucose cotransporter protein 2 inhibitors (SGLT2i) are antihyperglycemic agents that provide additional renal-...
https://www.tandfonline.com/doi/full/10.1080/0886022X.2024.2438857
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Alex Meraz
Kidney Medicine Journal
11 months ago
Case report: Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report
https://buff.ly/3P5dsSc
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Feliz Navidad!
11 months ago
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Alex Meraz
Ryan Town
12 months ago
💡 Kidney stone patients not meeting their fluid intake goals? Try this one weird trick! Sprinkle a little Carolina reaper powder on their food a couple times a day and 💦🆙 they'll be drinking so much water you'll be looking up the latest
#NephJC
on hyponatremia correction rates! GI docs hate him!
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Alex Meraz
American Journal of Kidney Diseases
12 months ago
Cumulative Blood Pressure Load and Incident CKD
https://bit.ly/4eEtmx7
#OpenAccess
#VisualAbstract
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Alex Meraz
Jeff Perl
12 months ago
Nope we use the patients usual dwell volume
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Is there any preferred dwell volume for IP antibiotics?
@pd-perls.bsky.social
#askrenal
#nephsky
12 months ago
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Alex Meraz
Brendon Neuen
12 months ago
Prevent kidney failure to reduce carbon emissions ♻️ 🍃 🏭 Our new analysis of CREDENCE assessing environmental impacts from ⬇️ hospitalisations & dialysis 🏥 with SGLT2i SGLT2i ⬇️ greenhouse gas emissions from inpatient bed days & dialysis by 20% (39 kg CO2e per yr)
www.thelancet.com/journals/lan...
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Kidney biopsy on aspirin, nay or yay? I am interested in your type 1, blink of an eye, kind of reasoning. Is Dr Glassock yet in Blue Sky?
#askrenal
#nephsky
@kidneyboy.bsky.social
12 months ago
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Alex Meraz
Amy A. Yau, MD
12 months ago
💊 Hydralazine (Hz) was first introduced to the market in 1951. The first case of Hz autoimmunity was in 1953, and the first series of Hz induced ANCA vasculitis overlapping with lupus was in 1984! But, who is really at high risk and what are the outcomes?
#nephsky
#nephtwitter
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Deleting X account today.
#bluesky
all the way
12 months ago
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Alex Meraz
Ron Filipkowski
about 1 year ago
23 million
1177
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Alex Meraz
UKidney
about 1 year ago
Reposting (fixed link): Check out our new and improved KFRE calculator with a nice visualization of kidney risk plotted on a KDIGO heatmap. For easy reference, go to
ukidney.com/kfre
✨ New features: • Interactive KDIGO heatmap • Clear risk visualization
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https://ukidney.com/kfre📊
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Alex Meraz
UKidney
about 1 year ago
Ever need help converting between different steroid doses or different immunosuppressive agents in transplant? • Envarsus to Cyclosporine IV? • Astagraf/Advagraf to Envarsus? • Prednisone to Solucortef? • And many more? We have you covered!
ukid.io/drugs
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#nephsky
add a skeleton here at some point
about 1 year ago
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Alex Meraz
John Scalzi
about 1 year ago
Others have noted it but I will too: The big reason Bluesky is so hot right now is that the people who add value to social media - the frequent posters in specific fields - are here now, talking to each other and creating the "spectator value" that draws users and attention.
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Twitter’s heir apparent isn’t X or Threads — it’s Bluesky
The blue bird is dead. Long live the blue sky.
https://www.theverge.com/2024/11/23/24303502/bluesky-next-twitter-threads-x
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#nephsky
add a skeleton here at some point
about 1 year ago
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Alex Meraz
Swapnil Hiremath 🍁🇨🇦
about 1 year ago
🦋will hit 22 million users tonight 🐦 & 🧵 have many magnitudes more users But it’s the quality and not the quantity of users that gives BlueSky the edge, says
@jaypeters.net
at
@theverge.com
www.theverge.com/2024/11/23/2...
h/t
@kidneyboy.bsky.social
via
@scalzi.com
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Twitter’s heir apparent isn’t X or Threads — it’s Bluesky
The blue bird is dead. Long live the blue sky.
https://www.theverge.com/2024/11/23/24303502/bluesky-next-twitter-threads-x
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Alex Meraz
Michael S. Balzer
about 1 year ago
Just finished a smooth migration of prior X tweets to
@bsky.app
. Shout-out to
@marcomaroni.it
for the excellent code! 🔥https://github.com/marcomaroni-github/twitter-to-bluesky
#NephSky
#MedSky
#NewHorizons
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Alex Meraz
about 1 year ago
How do we feel about this study (DAPA advKD)?
www.medscape.com/viewarticle/...
Does it answer the Q of initiating SGLT2-I in adv CKD? Are the numbers enough?
#nephsky
@kidneyboy.bsky.social
@hswapnil.bsky.social
@freelyfiltered.bsky.social
Maybe another one that could be discussed..
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Alex Meraz
Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
about 1 year ago
I hope that people who took an Ancestry or a 23&Me or simply had a relative who was sequenced for their cancer treatment understand they are one hack away from them and their facilities before they become uninsurable or unemployable once
#GINA
is revoked along with the ACA.
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Alex Meraz
Robert M Centor MACP
about 1 year ago
Hot take for
#nephsky
. I dislike the common use AKI for anyone with an elevated creatinine. Neither volume contraction nor obstruction cause significant injury. I find this use decreases thinking.
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Alex Meraz
Fernanda Arce-Amaré
about 1 year ago
‘A place of joy’: why scientists are joining the rush to Bluesky
@natureportfolio.bsky.social
#NephSky
#MedSky
www.nature.com/articles/d41...
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‘A place of joy’: why scientists are joining the rush to Bluesky
Researchers say the social-media platform — an alternative to X — offers more control over the content they see and the people they engage with.
https://www.nature.com/articles/d41586-024-03784-6
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Alex Meraz
Sarah Sanghavi
about 1 year ago
Just saw 2 ICU hyperNa cases, so here's a
#medsky
#nephsky🧵
on why... 🤨 Out: Solute-free H2O clearance 😎 In: Electrolyte-free H2O clearance 🫘 1st was recovering from AKI -->⬆️ filtered urea load as the BUN ⬇️ 🥩 2nd was receiving very high protein tube feeds -->⬆️ filtered urea load with stable BUN
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Alex Meraz
Nikhil Shah
about 1 year ago
The feed is still too slow for the live
#nephjc
chat, but seems to collect all the posts in discussion threads nicely. Looks great for following up after the chat!
bsky.app/profile/did:...
add a skeleton here at some point
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Alex Meraz
Nikhil Shah
about 1 year ago
I think this feed works well. It is based on the label.
bsky.app/profile/did:...
add a skeleton here at some point
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Alex Meraz
Sayna Norouzi, MD
about 1 year ago
Glomerular disease combined with case-based teaching? Count me in! 😄 It's my favorite part of
@ajkd.bsky.social
Check out this fascinating GN case here:
ajkd.org/article/S0272-…
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https://ajkd.org/article/S0272-…
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Alex Meraz
Rebecca Grainger
about 1 year ago
Hello, Blue Sky! I’m a kiwi Rheumatologist, educator, tech enthusiast with a global outlook, exploring health, resilience & science. Let’s make waves under clear skies!
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Alex Meraz
Nephrology Journal Club
about 1 year ago
🌍 Don’t forget to sign the @ISNkidneycare petition urging @WHO to prioritize kidney disease. Also, check out @hswapnil's insightful review! Every signature counts—let's go for the cause!
#NephJC
www.nephjc.com/news/isn-who...
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Making Kidney Health a Global Priority — NephJC
Let’s pus the WHO to make Kidney Health a global priority
http://www.nephjc.com/news/isn-who-petition?rq=isn%20petition
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Alex Meraz
Cristina Popa
about 1 year ago
A side point: classic RCTs in dialysis have problems with enrollment- RENAL AF, AXADIA-AFNET 8- even CONVINCE Maybe the solution is to design master trial protocols?- which cut costs, solve some of the generalizability issues (e.g. geographical distributions)
#nephjc
www.nephjc.com/news/master-...
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NephTrials: Basket Trials, Umbrella Trials, and the RENAL LIFECYCLE trial — NephJC
master trials umbrella trials platform trials basket trials RCT methodology flozins SGLT2 inhibitors NephTrials RENAL LIFECYCLE Dapagliflozin
https://www.nephjc.com/news/master-trials
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Alex Meraz
Jay 🦋
about 1 year ago
Bluesky now has over 20M people!! 🎉 We've been adding over a million users per day for the last few days. To celebrate, here are 20 fun facts about Bluesky:
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Alex Meraz
Tony Breu
about 1 year ago
I used
@en.blueark.app
to transfer tweetorials previously posted on Twitter here to
@bsky.app
. Very fair price and quick process. If you do the same, note my previous comments, particularly regarding links and search.
add a skeleton here at some point
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Alex Meraz
Juan Carlos Q Vélez, MD
about 1 year ago
Wondering why vasoconstrictors work in hepatorenal syndrome even though the pathogenesis is driven by renal vasoconstriction? Here is a conceptual explanation:
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Alex Meraz
Altmetric
about 1 year ago
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky
#HigherEd
#Altmetrics
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Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
https://docs.bsky.app/docs/advanced-guides/intent-links
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