How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Vanderbilt's division of Genetic Medicine has an open faculty position: apply.interfolio.com/177945

Additionally, the functional evidence for 275 SCN5A variants from our recent SCN5A automated patch-clamp study is now accessible in ClinVar.

A nice editorial about our recent SCN5A automated patch clamp paper. @chaiannng.bsky.social academic.oup.com/eurheartj/ad...

Whoa--Gemini Nano Banana is amazing at turning a "napkin sketch" of a molecular pathway into a nice-looking figure! 🤯

Excited to share our preprint: “Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia Risk!” We performed ~50,000 experimental measurements of KCNQ1 variants. www.medrxiv.org/content/10.64898/2025.12.15.25341924v1

The effects of genetic variants primarily occur in differentiated cells meaning we need to access these cell types to measure variant effects for most disease genes. We developed saturation genome editing in stem cells (iPSC-SGE) to enable phenotyping in diverse genetic and cell contexts at scale!

The Mosley lab is seeking creative postdoctoral fellows interested in applying innovative population-based genomic and informatics approaches to translate genetics into clinical settings. labs.utsouthwestern.edu/mosley-lab/p... www.utsouthwestern.edu/research/pos... 🧪🧬🖥️

Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.

📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]

Congrats to Matthew O'Neill for winning an American Heart Association Early Career award for our work on functional studies of SCN5A variants from patients with Brugada syndrome!

So excited about this new work from our CardioVar consortium out this week in Science led by the amazing Daniel Tabet and @fritzroth.bsky.social. www.science.org/doi/10.1126/

I gave my daughter C, A, and T cards to spell "cat." She grabbed a G and added it to the mix. Is she hinting at a future career in genetics? 🧬 🐾

🧬 Out this month in Nature Reviews Cardiology: A powerful look at how multiplexed assays of variant effects (MAVEs) are reshaping our understanding of cardiovascular disease genetics. Contributors include members of the AVE Alliance. 📑 www.nature.com/articles/s41... #Cardiology #FunctionalGenomics

The 9th Annual Mutational Scanning Symposium will be held in Melbourne, Australia March 25-27, 2026 🌟 #VariantEffect26 www.mss2026.org Registration will open soon!!!!

📣New today! 📄Landscapes of missense variant impact for human superoxide dismutase 1 🧑‍🤝‍🧑 @axakova.bsky.social @fritzroth.bsky.social & co

And follow it up with @natrevcardiol.nature.com's review on the application of MAVEs in cardiology by @amglazer.bsky.social et al. Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine go.nature.com/3JOJYc3 rdcu.be/eFmoe

📝Check out our review “Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine”, out in @natrevcardiol.nature.com. We review the use of Multiplexed Assays of Variant Effect and variant effect predictors in cardiovascular disease.

Our study on HCM intermediate effect variants (IEVs) is out today in Circulation, led by Juan Pablo Ochoa, Soledad García Hernandez and Luis De la Higuera Romero. IEVs are low frequency/penetrance variants with moderate effects sizes (OR:5-10). www.ahajournals.org/doi/10.1161/... #ESCcongress 🧬🫀

Having some summer fun...Glazer Lab Olympics! Our lab competed in 6 lab-themed events.

More smiles to share with you; this time, Andrew Glazer and Richard Dolder from the Glazer Lab at Vanderbilt University Medical Center. New blog: timothysyndrome.org/research/det... #CACNA1C #RareDisease #Research @amglazer.bsky.social @vanderbilt.edu

My wife and I had a lovely time in Spain, including the excellent #VariantEffect25 meeting!

Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542... 1/n

Congratulations, John Shelley. news.vumc.org/2025/04/25/p... #VUMCMSTP #VUMCDBMI #PopGen #Bioinformatics #Genomics 🧬🖥️🧪

New paper out in Genome Biology! 🎉 We lay out best-practice guidelines for releasing variant effect predictors, developed through the Atlas of Variant Effects Alliance @varianteffect.bsky.social Open, interpretable, and clinically useful VEPs are the goal. 📄 doi.org/10.1186/s130...

📣New from Bastarache & co 📄Characterizing trends in clinical genetic testing: A single-center analysis of EHR data from 1.8 million patients over two decades

🚨I could not be more excited to share our new preprint on saturation genome editing of the small nuclear RNA (snRNA) RNU4-2: www.medrxiv.org/content/10.1... A super fun collaboration with incredible duo @gregfindlay.bsky.social @joachimdejonghe.bsky.social from @crick.ac.uk 🧬🖥️🩺 🧵1/12

I am pleased to share this @ahajournals.bsky.social CircGen paper. It is a team effort. I hope we have provided valuable insights on how KCNH2 variant that alters splicing and causes a large in-frame deletion can lead to a dominant negative effect of Kv11.1 K+ #ionchannel function.

It was great to attend the ACMG clinical genetics meeting for the first time, including a fun session on advances in cardiovascular genomics.

🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]

The 8th Annual Mutational Scanning Symposium is just around the corner! #VariantEffect25 What we are looking forward to: 🗣️Great talks! 🛠️Workshops! 🏆Poster session and awards! 🌏Amazing community! ⌛️March 1st deadline for abstracts!

Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29 Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social www.sciencedirect.com/science/arti...

I have always wanted to work with testing laboratories to integrate #ionchannel functional data into their variant classification workflow to reclassify harmful variants as likely pathogenic and improve genetic diagnosis for patients with channelopathies. Under review, but preprint is available.

“NIH is accordingly imposing a standard indirect cost rate on all grants of 15%”

Congrats Ellen on winning the lab ping pong tournament!

Gotta test them all.

Just updated this figure for 2025. There are now over 1 million missense Variants of Uncertain Significance in Clinvar!

🎉 Registration is now open for the 8th Annual Mutational Scanning Symposium #VariantEffect25 ℹ️ events.ibecbarcelona.eu/mutational-s...

I started working on genetic therapies for Mendelian disease in 2000 - and in the subsequent 25 years have never seen a disease where the molecular aetiology has undergone as giant an "OH WOW" moment as this. www.cell.com/cell/fulltex...

A PAS-targeting hERG1 activator reduces arrhythmic events in Jervell and Lange-Nielsen syndrome patient-derived hiPSC-CMs @jci-insight.bsky.social insight.jci.org/articles/vie...

Happy New Year! (and first post here 😀) Excited to share the final version of our work where we combine deep mutational scanning, cryo-EM, and molecular dynamics to further resolve the mechanisms of pH sensing in GPCRs. 🧵(1/n) www.cell.com/cell/fulltex...

Congrats @willowcoyote.bsky.social @amanglik.bsky.social and all authors on a tour de force dissection of proton-sensing by GPCRs! DMS, cryo-EM, MD -- it has it all! www.cell.com/cell/fulltex...

Yes! Image is the second page from our writing guidelines, but of course reading is essential beyond just for writing. In addition to the points in the thread below, I also recommend practicing multiple tiers of reading (skim, browse figures, read, read in depth) github.com/KULL-Centre/...

Titin is massive in size – at 3,800kD it’s the largest protein in your body and really important for heart function. In a new paper, led by Yuri Kim and the Seidman lab, we describe an enhancer critical for normal Titin expression. Here is the overview (1/n) Paper: www.jci.org/articles/vie...

Congrats to my PhD student Trey who received an American Heart Association fellowship!

There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...

👀 A 10 page paper caused a recent panic because of a math error. I was curious if AI would spot the error by just prompting: “carefully check the math in this paper” especially as the info is not in training data. o1 gets it in one shot. This feels like a big capability gain for scientific work

Dear ion channel community - come and join us for an exciting talk by @corrylab.bsky.social next Tuesday on sodium channel fast inactivation. Do you still believe in ball-and-chain? Or rather rings obliterating the pore? Something else? Then come and discuss with us at the #WSCS! #ionchannels #Nav

This morning's MDT was productive. It brought together cardiologists, clinical geneticists, genetic counsellors, research scientists, and the head of my local clinical testing laboratory to discuss and reclassify a suspicious SCN5A VUS as pathogenic. It was a good outcome for this family but 1/2