We Are Watching a Scientific Superpower Destroy Itself @nytimes.com www.nytimes.com/2025/09/08/o...

Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism @nature.com www.nature.com/articles/s41...

Senate committee endorses NIH budget increase, rebuking Trump administration’s proposed 40% cut @statnews.com

Great clinician, scientist, and even better person! www.medicine.wisc.edu/news/0725202...

Phenomenal learning at the week long ACP board review course in Philadelphia!

Physiological pacing: mechanisms, clinical indications, and perspectives🔓 academic.oup.com/eurheartj/ad...

Great to catch up with PhD advisor in Philly Once a mentor always a mentor 👍

Check out #PanEcho, now in @jama.com ✅ open weights ✅ multiview multitask reporting ✅ international validation ✅ works with POCUS Amazing effort @cardslab.bsky.social @giholste.bsky.social @rohankhera.bsky.social + @atlaswang.bsky.social, Márton Tokodi & Attila Kovács #CardioSky #EchoSky

"A terrifying imbalance lies at the heart of every doctor-patient relationship: The doctor can ask practically anything about the patient... The patient knows almost nothing about the person in the white coat...” @nytimes.com www.nytimes.com/2025/06/24/w...

New online! Mechano-energetic uncoupling in heart failure #CardioSky

What. The. Fuq. 😩 My previous #studentloan payment was ~$250. Even though no payment is currently required, I have faithfully made that same payment each month. But now #Trump has killed my #science 🧪 job options through #NIH cuts and on top he wants a rent note. How are other trainees coping rn?

I'm a current Harvard graduate student and I found out today that I had my NSF GRFP terminated without notification. I was awarded this individual research fellowship before even choosing Harvard as my graduate school

Innovation takes time US scientists who received renewals from the NIH over the past four decades produced more novel research than those who didn’t https://go.nature.com/44s6cc5

Budget released today: 40% cut to NIH 50% cut to NSF If enacted, this will destroy academic research in the United States. It will also have a major trickle down effect on the entire academic ecosystem

Welp, it begins. Sigma Aldrich.

Staff members at the US National Science Foundation (NSF) were told on 30 April to “stop awarding all funding actions until further notice,” according to an email seen by Nature. https://go.nature.com/44Ugf9V

Amazing time at the m AAP/ASCI/APSA meeting with great science and friends!

🚨The application deadline for the 2025 SGP Excelsior Award is 1 June 2025. Learn more and apply at sgpweb.org/awards/excel...

"American science is the envy of the world, but this global leadership is now threatened by draconian cuts to federal support of biomedical research through the defunding of grants and drastic reductions in funding for essential research costs and infrastructure."

Contemporary management of HF with improved EF, specifically thoughts on who and when to peel back medical therapies. www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social #cardiosky

"Those who do not accept vaccination remain susceptible to the infections against which the vaccines were developed, and they serve as vectors for the spread of the infections to unvaccinated individuals" www.inquirer.com/opinion/comm...

America’s Brightest Minds Will Walk Away www.nytimes.com/2025/04/03/o... ⁦

Conduction system pacing: promoting the physiology to prevent HF Background and Clinical perspectives of HBP and LBBP area in HF link.springer.com/article/10.1... #HF #CardioSky #CardioEd @cardioobdoc.bsky.social @drrajivsankar.bsky.social @annakatebarton.bsky.social @vietheartpa.bsky.social

Some 2,000 scientists, including dozens of Nobel Prize winners, have signed an open letter warning that the U.S. lead in science is being "decimated" by the Trump administration's cuts to research.

‘One of the darkest days’: NIH purges agency leadership amid mass layoffs @nature.com www.nature.com/articles/d41...

Great @sgpweb.bsky.social EPIC seminar on BK channel auxiliary subunits! So much mechanism could be uncovered by this investigation

At today's Congressional Forum, Dr. Larry Saltzman testified that NIH-funded research was crucial to his 15-year survival with chronic lymphocytic leukemia. "For patients waiting on the next treatment, time is everything. These cuts could rob us of the time we need most."

Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process. www.nature.com/articles/s41... www.nature.com/articles/d41... Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com

Now and competitive renewals 2/3

Well stated. www.nytimes.com/2025/03/24/h...

openRxiv has arrived! We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences. openrxiv.org/introducing-... #openRxiv #OpenScience #Preprints #bioRxiv #medRxiv

Science and celebration of it should not pause!

🚨📝🐞 Check out a new case report describing prompt diagnosis and treatment of Tick-Borne Relapsing Fever identified in Wisconsin wmjonline.org/wp-content/u...

Congrats Shujia and team! An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons | Science Advances www.science.org/doi/full/10....

Strong Wisconsin delegation at the Gordon conference on cardiac arrhythmia mechanisms 🇮🇹

First day of Cardiac Arrhythmia Mechanisms GRC today in Tuscany Italy! 🍷🔬

I totally crashed this one! @renaeryan.bsky.social @francesbiophys.bsky.social @frettinglab.bsky.social, Gail, and Teresa. #BPS2025

Worst flu season in over a decade is not the time for this. www.npr.org/sections/sho...

The cost-saving claims don’t hold up. Every dollar in NIH research grants generates $2.46 in economic activity, research shows—a total of $93 billion in 2023 alone. “It’s incredible to me that we would give up this thing that has such obvious societal benefits,” says biologist Mark Peifer.

Love this review "Management of Electrical Storm" ⚡️ @jaccjournals.bsky.social www.jacc.org/doi/10.1016/...

"We found that cholesterol depletion significantly increased the sensitivity of the whole cell [hERG] current to inhibition by ibutilide, while decreasing the currents sensitivity to dofetilide and amiodarone at negative membrane potentials.” www.sciencedirect.com/science/arti...

This review from Worawan Limpitikul and Ivy Dick @ummedschool.bsky.social considers the inactivation mechanisms of Caᵥ1 and Caᵥ2 voltage-gated calcium channels and their role in normal physiology and pathophysiology. https://buff.ly/40B8WAo #Biophysics #MolecularPhysiology #IonChannels

Welp. This is unusual.

A study in Nature Medicine reports greater mortality from infectious and parasitic diseases, injuries and respiratory and cardiovascular diseases associated with exposures to flooding events in the US, particularly floods caused by tropical cyclones and heavy rain. #Medsky 🧪

““I’m very worried about the next generation of scientists. We need the very best and brightest to go into science. We know that when funding is low, and when respect for science is low, that it really hurts the next generation.” @nature.com ‬⁩

Seems more important than ever... support the NIH and NSF

🚨🫀⏰ Delisle et al 😉 review circadian mechanisms and sudden cardiac death🧬 Day-night cycles in ion channel regulation and myocardial protection impact arrhythmia risk💓👉 www.jmcc-online.com/article/S002... #IonChannels #Circadian #CardioSky #Arrhythmias #Physiology

Despite unprecedented setbacks, which challenge our ability to do “science as usual,” @biophysicalsoc.bsky.social remains committed to our mission and values. I look forward to connecting in LA: the science must go on! mailchi.mp/biophysics/c...

Per an NIH source: “Discussions with colleagues have suggested that if the universities all come together and raise hell about the delays to funding caused by not holding meetings, that might move the needle. From every state. There are well-funded universities in red states that will be impacted.”

This is going to grind all new federal science funding to a halt if my reading is accurate. 🧪⚛️