CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis: @cellpress.bsky.social www.cell.com/cell/fulltex...

3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...

Microglia checkpoints promote healthy myelin aging Our new paper is out in Nature Neuroscience @natneuro.nature.com www.nature.com/articles/s41... 🧵1/3

With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.

There’s an art to writing a grant proposal so that your creativity is on full display. Maria Leptin - president of the ERC - talks about it on the new episode of the Night Science Podcast.

First paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome. 🔗 biorxiv.org/content/10.1... A short thread (by Juliane Weller)👇

We are hiring!! Interested in applying various CRISPR editing approaches and cell profiling to address functional metabolic and epigenetic interplay in oligodendrocytes?! Apply here 👇 www.linkedin.com/posts/karl-c...

A new study in @natneuro.nature.com by @gocastelobranco.bsky.social et al explores how oligodendrocytes respond in #MultipleSclerosis. The researchers identified distinct and early disease-related states and gene activity patterns that may help explain how #MS progresses 🧪 news.ki.se/oligodendroc...

Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com! Check it out at: www.nature.com/articles/s41... with @pkukanja.bsky.social, @deckardw.bsky.social, among others

New preprint from @gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes. www.biorxiv.org/content/10.1...

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

Researchers at KI and @yale.edu have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation. The study is published in @nature.com. 🧪 #neuroscience news.ki.se/scientists-m...

Researchers @ki.se and Yale University have created a multidimensional, molecular map of how the mouse #brain develops after birth and how it reacts to #inflammation #research supported by Knut and Alice Wallenberg Foundation #MS #neuroscience @gocastelobranco.bsky.social news.ki.se/scientists-m...

Latest from the lab in colab with @rongfan8.bsky.social

Låter som något äkta gnällisar skulle säga.

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...

A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change. Opening a number of future avenues. 📰 Via @GenomeWeb : lnkd.in/djYm_sGg #epigenetics #singlecell

Min vän Jovan har startat cykelverkstad i Gubbängens centrum cykelnomad.com. Blev en räddad palm som inflyttningspresent. Vi jobbade tillsammans för 10 år sedan och han har jobbat heltid som cykelmekaniker sen dess. Sprid gärna ordet så han kommer igång ordentligt!

Of David's countless accomplishments is the important work that Matt Porteus did in his lab on early-stage genome editing with engineered nucleases (pubmed 12730593). He and Matt both speak about this in the documentary "Human Nature." A true titan. www.nytimes.com/2025/09/07/s...

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!

A careful, comprehensive and creative characterization of T cell dynamics in response to pathogens, with all credits going to @rohamparsa.bsky.social who just opened his lab!

Excited to share our new preprint! We studied how T cells are functionally & clonally shaped across organs over time. With the new TRACK mice, we genetically label recently activated T cells with tdTomato and track their migration across tissues. #immunology #science www.biorxiv.org/content/10.1...

Träffade SR:s Mellanösternkorrespondent Cecilia Uddén och pratade om Gaza, opartisk journalistik och sorgen efter hennes kärlek Elisabet Ohlson.

Deadline (September 2) approaching! Join us and start your lab at @ki.se!

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development. Funded by @asapresearch.parkinsonsroadmap.org www.cell.com/cell-genomic...

I am hiring an halftime administrative assistant for my lab! we are fun dynamic group located in Bonn DZNE. Pls Spread the word. Learn more & apply karriereamukb.de/jobs/teamass...

Tillbaka i tjänst och första texten handlar naturligtvis om RFK jr. Det är svårt att ignorera allt som han gör och förstör. (Premium, men kan läsas om man har en prenumeration på någon Bonnier-titel via Plus allt)

Join us at the FENS Single-Cell & Spatial Omics Winter School with: @sarabiz86.bsky.social @rongfan8.bsky.social @gokcegroup.bsky.social @gioelelamanno.bsky.social @sj-marzi.bsky.social @jplopez-atalaya.bsky.social Ana Falcão Florian Rosenberger Gabriel Baró Bosiljka Tasic Barbara Treutlein

The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town. Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. 🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41... 🧵Let’s break down what makes DynaTag so powerful (1/7)

1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77

Herregud vad uselt chefredaktören på DN svarar. Det är så pinsamt, så skamligt. Återigen: ingen av alla dessa medlöpare och självpåtagna censorer som bidragit till att folkmordet har fått fortgå ohejdat ska någonsin få glömma det.

12th Dev Brains: @junyuecao.bsky.social @alainchedotal.bsky.social @cecilecharrier.bsky.social @trayon.bsky.social Isabel Espinosa-Medina Beatriz Rico Michael Ziller Dwight Bergles news.ki.se/calendar/dev... @hjerling-leffler.bsky.social @ulrikakmarklund.bsky.social @flallemend.bsky.social

@carlstrom.bsky.social Clemens Ries, and Ting Sun rocking at #GLIA2025! And the launch of the Carlström lab!

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

On now, last session of #Glia2025, and last presenter from the lab. S26 | Exploring glial diversity using single cell and spatial genomics @mrodea.bsky.social 10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain

This is insane! "'Positive review only': Researchers hide AI prompts in papers" asia.nikkei.com/Business/Tec... h/t Ryan Pack

#GLIA2025 is in full swing! We’re halfway through an exciting week full of energy, ideas, and exchange. Highlights so far: 🎓 Stipend Award Session 🧠 Poster Sessions 🤝 Welcome Reception Let’s keep the momentum going! #GliologistsTogether

And for the poster session II at #EuroGlia the French Glial Cell Club is still present!

I am super happy that we have had so many visitors at the booth. #gliaRules #glia2025

What a start to #GLIA2025! We kicked off with an inspiring Opening Ceremony, our first lively Poster Session, and a warm Welcome Reception. The day ended with great conversations at the Peripheral Glia Social at The Black Stone. More to come – stay tuned!

If you're attending @gliameeting.bsky.social #glia2025 check out Lucy Ryan's talk in the trainee symposia (17) on Thursday & poster T14-001A on heterogeneity of oligodendrocyte pathology in Alzheimer's disease!

The poster session at Euroglia #Euroglia2025 #GlialCells #Neuroscience

Bruno Weber plenary lecture at #Glia2025 #FLIM The auditorium is full! ✅ Neurons can sustain activity with lactate ✅ Astrocytes become more oxidized under a ketogenic diet. ✅ Similar glucose concentrations in astrocytes and neurones ✅ Higher concentration in the ECS!

We’ve arrived in sunny Marseille and everything’s set for #GLIA2025! The Introductory Course kicked things off today — and we’re ready for an inspiring week ahead. See you soon! #GLIA2025 #GliologistsTogether