@chopralab.bsky.social
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reposted by
Department of Chemistry, Stanford University
3 months ago
Joining us from Purdue, Prof. Gaurav Chopra will be giving a Chemical Biology Seminar on "How do Glial and Immune Cells become Dysfunctional in Aging and Neurodegeneration?" today at 3PM in STLC 114.
chemistry.stanford.edu/events/chemi...
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Chemical Biology Seminar: Professor Gaurav Chopra, Purdue University | Chemistry
About the Seminar"How do Glial and Immune Cells become Dysfunctional in Aging and Neurodegeneration?"Pathogenic aging leads to neurodegeneration and imposes chronic metabolic stress on the brain, rewi...
https://chemistry.stanford.edu/events/chemical-biology-seminar-professor-gaurav-chopra-purdue-university
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🚨 Catch the MIND Lab at
#ASMS2025
! Our trainees present cutting-edge work on AI-agents, lipidomics, & neurodegeneration in talks & posters all week. From AI-agents to single-cell FA profiling to PROTAC proteomics—don’t miss it!🧠#AIagents
#Neuroimmunology
#Lipidomics
@asms.org
8 months ago
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Our Immunity
@cp-immunity.bsky.social
Cover was not selected but nothing can hold back the Microglia super-heroine when she has DGAT2-blocking beverage.
#NotTheCover
Read the full article in Immunity:
www.cell.com/immunity/ful...
add a skeleton here at some point
8 months ago
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reposted by
Dimitrios Davalos & Lab
8 months ago
Microglia: A super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (LD weights) and lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)!
#NotTheCover
@cp-immunity.bsky.social
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reposted by
Dimitrios Davalos & Lab
8 months ago
Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript
@cp-immunity.bsky.social
👇🏼
www.cell.com/immunity/abs...
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Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...
https://www.cell.com/immunity/abstract/S1074-7613(25)00192-X
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reposted by
Priya Prakash
8 months ago
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now
@cp-immunity.bsky.social
! ➡️
www.cell.com/immunity/ful...
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Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00192-X
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