Bryan Yipp (@bryanyipp.bsky.social)

A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses Severe pneumonia is predominantly caused by cytokine storms in the lung, but how this process is controlled remains unclear. Li et al. find that severe pneumonia activates central amygdala GABAergic neurons, which triggers a sympathetic nerve-pulmonary interstitial macrophage interaction that amplifies lung inflammation. Blocking this pathway reduces harmful inflammation and cytokine storms, offering a promising therapeutic target for severe pneumonia. http://dlvr.it/TMS3ll