Lena Spieth
@lenaspieth.bsky.social
š¤ 374
š„ 74
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Postdoctoral researcher at DZNE and TU Munich. Glia enthusiast š§ lipid lover š¤æ diver.
Our new paper reveals that chronic active MS lesions feature CD8āŗ T cell niches with lipid-laden, inflamed microglia. IFN-Ī³ drives cholesterol buildup, linking dysregulated lipid metabolism to inflammation and meurodeg. Check it out
@cp-immunity.bsky.social
www.sciencedirect.com/science/arti...
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Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions
Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. Aā¦
https://www.sciencedirect.com/science/article/pii/S1074761325004339
4 days ago
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reposted by
Lena Spieth
Hauke Werner
2 months ago
If you're interested in trafficking of
#myelin
constituents in
#oligodendrocytes
, and of course you are, you may want to check out our new preprint. It's very nice PhD work by
@sophiesiems.bsky.social
, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
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Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system
Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...
https://www.biorxiv.org/content/10.1101/2025.09.02.673641v1
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reposted by
Lena Spieth
Sarah Marzi
6 months ago
How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain š§ š§¬ New paper out in
@natcomms.nature.com
today:
www.nature.com/articles/s41...
@ukdri.ac.uk
@kingsioppn.bsky.social
@imperialbrains.bsky.social
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https://nature.com/articles/s4146ā¦
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Nature Neuroscience
9 months ago
A Review on
#oligodendrocytes
in Alzheimerās disease pathophysiology from Shreeya Kedia & Mikael Simons š§Ŗš§
www.nature.com/articles/s41...
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Oligodendrocytes in Alzheimerās disease pathophysiology - Nature Neuroscience
Emerging evidence highlights the dual role of oligodendrocytes in Alzheimerās disease, both providing protective mechanisms against the pathology and contributing to its progression.
https://www.nature.com/articles/s41593-025-01873-x
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5FAD transgene parentage influences plaque burden. š Congratulations
@aosasmita.bsky.social
,
@taisiianazarenko.bsky.social
@constanze depp and @Klaus-Armin Nave. Happy to have contributed a little.
add a skeleton here at some point
10 months ago
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reposted by
Lena Spieth
Janos Groh
10 months ago
How does aging affect the white matter and what are the consequences for brain function and neurodegenerative disease? Thankful to see this review with Mika Simons now published in a fascinating collection on the science of brain aging
@cp-neuron.bsky.social
www.cell.com/neuron/fullt...
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White matter aging and its impact on brain function
Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes further damage. Understanding these changes is key to preventing age-related neurodegenerative disease.
https://www.cell.com/neuron/fulltext/S0896-6273%2824%2900767-0
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Lena Spieth
Sarah JƤkel
10 months ago
Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.
journals.plos.org/plosbiology/...
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Are oligodendrocytes bystanders or drivers of Parkinsonās disease pathology?
The major pathological feature of Parkinson ās disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002977
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reposted by
Lena Spieth
Andrew Octavian Sasmita
11 months ago
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimerās Disease This further adds to the mounting evidence that microglia are perhaps much better at AĪ² plaque formation than plaque clearance. What a fantastic study š¤©
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Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimerās Disease - Nature Communications
The role of microglia in Alzheimerās disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...
https://www.nature.com/articles/s41467-024-54779-w
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Fixation time affects RNA scope results in human FFPE brains. Check out this paper from the JƤkel lab!
add a skeleton here at some point
12 months ago
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