We’re hiring! Two postdoc positions are open in the Translational Neuroproteomics lab at Mayo Clinic Florida, focusing on tau and TDP-43 proteinopathies and neurodegeneration in ALS, FTD, and AD. www.mayo.edu/research/lab... Apply here: 1) tinyurl.com/2p9n59y5 2) tinyurl.com/em2zpu2j Please share!

Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding @dormannlab.bsky.social www.embopress.org/doi/full/10....

We have developed an entirely new mechanism of action for gene knockdown -> trafficking of targeted mRNAs to the lysosomal, using lysosomal trafficking oligonucleotides (LyTONs)! Published in @chemicalscience.rsc.org Led by Disha Kashyap #chemsky 🧪 pubs.rsc.org/en/content/a...

We are thrilled that Prof Philip Wong, Ph.D., of John Hopkins Medicine will be our next webinar speaker! "An AAV gene therapy for #ALS-#FTD guided by a presymptomatic #biomarker" May 29, 2025 1:30-2:30 PM (ET) Host: @rossolllab.bsky.social Register: bit.ly/4jRnCDa

Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD TDP-43 APEX proximity labeling to identify interactors for cytoplasmic (ΔNLS) and RNA-binding deficient (5FL) TDP variants! By Longxin Xie and @donnellylab.bsky.social. www.biorxiv.org/content/10.1...

I was thrilled for the opportunity to present today #ADPD2025 the work @PrudencioLab, in the wonderful city of Vienna where I was lucky to get an awesome tour by Dr Wilfried Rossoll! @rossolllab.bsky.social

Join Dr Grinberg’s team at Mayo Clinic exploring sleep dysfunction in neurodegenerative diseases, with advanced training and exceptional career prospects. Closing date: 25th May www.dementiaresearcher.nihr.ac.uk/job/research...

Our proximity proteomics study introducing Probe‑dependent Proximity Profiling (ProPPr) and applying it for profiling tau pathology‑associated proteins in tauopathies + @drneurochic.bsky.social & others is out now! @cziscience.bsky.social molecularneurodegeneration.biomedcentral.com/articles/10....

“In neurons, RiboExM revealed a functional dichotomy between monosomes and polysomes. Monosomes were enriched in distal neurites at baseline, whereas polysomes formed dynamically in response to external stimuli…” www.science.org/doi/10.1126/...

A new understanding of tissue biology from MS-based proteomics at single-cell resolution www.nature.com/artic... --- #proteomics #prot-paper

The nano splits paper is out! Single cell seq and single cell proteomics on the same single (one) normal sized human cell! proteomicsnews.blogspot.com/2024/12/the-...

Final episode of “what is a proteomics?” on #THEProteomicsShow with me and @proteomicsnews.bsky.social. This week we had Dorte Bekker-Jensen on talking about who can do proteomics. Obviously anyone, right?! Get it wherever you get fine podcasts.

Benjamin Ryskeldi-Falcon’s @brfalcon.bsky.social group in the LMB’s Neurobiology Division, with Karen Duff's group at the UK DRI, have discovered that tau filaments are tethered to the membranes of extracellular vesicles in #Alzheimers Read more: www2.mrc-lmb.cam.ac.uk/cryo-et-reve... #LMBResearch

‘A place of joy’: why scientists are joining the rush to Bluesky www.nature.com/articles/d41...

An impressive display of technologies was used to discover how cryptic #splicing causes #celldeath and leads to development of human #diseases. www.science.org/doi/10.1126/... It was a real joy to work together with @prieto-garcia.bsky.social and all other collaborators. Many thx 👍😀

Looks like PPS Silent Surfactant, Progenta anionic acid labile surfactant (AALS) I, AALS II, cationic acid labile surfactant (CALS) I, and CALS II are not commercially available anymore

Can someone please point us to a source for mass spectrometry compatible surfactants less pricey than Invitrosol, ProteaseMax, and RapiGest SF? DDM did not work that well in our hands for FFPE tissue extraction and proteomics.

2nd biennial conference on TDP-43 function and dysfunction in disease" 9-11 September 2025 | Trieste, Italy www.icgeb.org/tdp43-confer...

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...

News in Proteomics Research | Astral vs TIMSTOF Ultra on real single cells? Just about evenly unreal numbers! proteomicsnews.blogs... --- #proteomics #prot-other

Download our database of 313 different postdoctoral fellowships. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download our database here: research.jhu.edu/rdt/funding-...

FUS controls muscle differentiation and structure through LLPS mediated recruitment of MEF2 and ETV5 https://www.biorxiv.org/content/10.1101/2024.09.18.613669v1

Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W https://www.biorxiv.org/content/10.1101/2024.04.29.591661v1

Interesting MAPT model x w/ APP KI

Exhilarated to share the first original study from my lab published online @ImmunityCP. A great team endeavor spearheaded by the fantastic Sofia P. das Neves 😁 “Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination” www.cell.com/immunity/ful...

Excited to share our latest work! In it, we develop a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity-based methods, labels deposited on RNAs are read directly by sequencing without the need for biotinylation. biorxiv.org/cgi/content/...