Publication alert!!📑 Congrats to the @dikiclab.bsky.social and Beli labs on their joint #SFB1361 publication, covering how DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality. 🔎Read the paper here: www.science.org/doi/10.1126/...

Unrepaired DNA-protein crosslinks cause a process that leads to premature aging and embryonic lethality in mice. The findings in Science reveal a previously unrecognized link between defective DNA repair and immune-driven inflammatory disease. https://scim.ag/4qdZWf9

Our Science paper is out! 😃 www.science.org/doi/10.1126/...

🧪🧬 Wenn das DNA-Reparaturenzym SPRTN ausfällt, häufen sich DNA-Schäden, Entzündungen werden ausgelöst und Alterungsprozesse beschleunigt. Das zeigt eine #Studie unter Leitung von @idikic.bsky.social vom @ibc2-gu.bsky.social an der #GoetheUni. | 🔗 aktuelles.uni-frankfurt.de/forschung/ka...

Our Science paper is out! 😃 www.science.org/doi/10.1126/...

Out now in @science.org DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality www.science.org/doi/10.1126/... @science.org @idikic.bsky.social @goetheuni.bsky.social

Honored to receive the RMU Award for Pharmaceutical Research & Innovative Medical Therapies for our discovery of proteotoxic RNA splicing! Huge thanks to RMU @goetheuni.bsky.social @ibc2-gu.bsky.social & @idikic.bsky.social ! 🧬 #RMU #Science www.rhein-main-universitaeten.de/en/news/rmu-...

Honored to receive the RMU Award for Pharmaceutical Research & Innovative Medical Therapies for our discovery of proteotoxic RNA splicing! Huge thanks to RMU @goetheuni.bsky.social @ibc2-gu.bsky.social & @idikic.bsky.social ! 🧬 #RMU #Science www.rhein-main-universitaeten.de/en/news/rmu-...

"m6A in the coding sequence: linking deposition, translation and decay" by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues "This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..." Read it here: authors.elsevier.com/sd/article/S...

Very happy to share some exciting news! I have been awarded a Ramón y Cajal Fellowship 2024 #ryc2024 in the area of Biomedicine, having ranked 4th out of 262 applications with a final score of 99.4 out of 100.

🟠 SCIENCE | Extra Seminar: "Targeting proteotoxic RNA splicing for therapeutic intervention" 👤: Cristian Prieto-García 🗓️: 11-04-2025 | 12:00 h. 📍: IBiS Assembly Hall + INFO ➡️ www.ibis-sevilla.es/es/eventos/2... @csic.es @goetheuni.bsky.social @unisevilla.bsky.social

🤩 2nd day of #FCQC2025 conference in Frankfurt was filled with inspiring lectures, vibrant discussions, great posters and a lot of joy of meeting colleagues from all over the world! A huge thanks to all organizers & supporters! @goetheuni.bsky.social @sfb1177.bsky.social @proxidrugs.bsky.social

RNA Salon in mRNA Translation We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft) Please RT @goetheuni.bsky.social @cpi-exstra.bsky.social

Retinosis pigmentosas en clínica e investigación! www.rtve.es/play/audios/...

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...

Today, we had the privilege of having @prieto-garcia.bsky.social at @IMIBIC talking about splicing, USP38, and proteostasis. A magnificent talk and excellent work! 🧬🧪🧫

It was great to share Science with people at the IMIBIC! Great place 🙂. Really thanks to Manuel D. Gahete for the invitation and thanks to @marcoacalzado.bsky.social , Raul , @betsaidaop.bsky.social and others for nice time and plenty Scientific discussions.

Interested in #TPD? This might be for you. What concentrations of UPS inhibitors are safe to use to prove your proteasome dependent degradation mechanism? #PROTAC #TPD #degradation #Science #drugdiscovery pubs.acs.org/doi/10.1021/...

Muchas gracias @fdescubre.bsky.social y @canalsurradio.bsky.social / @canalsurnoticias.bsky.social por permitirme compartir un poquito de ciencia con Andalucia y poder explicar nuestro último Science paper desarrollado en @dikiclab.bsky.social www.canalsur.es/multimedia.h...

🥁 We are live on BlueSky!! Stay tuned for more news and updates from our lab. We are looking forward to connecting with you here again. @ibc2-gu.bsky.social @idikic.bsky.social #GoetheUniversity #IBC2

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!

"I don’t think I would’ve been better off being a biologist to begin with" Karen Liu @karenjliu.bsky.social, now a professor in #DevBio, worked in an architectural firm before deciding to pursue a scientific career in her late 20s. Read her interview here: thenode.biologists.com/i-dont-think...

#ciencia #investigación www.diariosur.es/malaga/corre... @prieto-garcia.bsky.social Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

Más investigación de calidad de científicos españoles intentando entender los mecanismos de reciclado de proteínas y de autofagia y su importancia en la salud. Enhorabuena. www.science.org/doi/10.1126/...

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

Arise, UPR & ISR scientists ! I will have missed many, so please tag below go.bsky.app/8VzRKLW

Among so many amazing starter packs, but none focused on RNA splicing - so we made one! Check out the accounts we’ve included so far, and let us know if you’d like to be added or have suggestions! go.bsky.app/TigRnmC #rnasplicing

Doing good science is 90% finding a science buddy to constantly talk to about the project.

After much excitement about seeing our paper: “ Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy ” published in @ScienceMagazine, it’s time to summarize our discoveries here! 😊 1/20 www.science.org/doi/10.1126/...

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...

After much excitement about seeing our paper: “ Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy ” published in @ScienceMagazine, it’s time to summarize our discoveries here! 😊 1/20 www.science.org/doi/10.1126/...

An impressive display of technologies was used to discover how cryptic #splicing causes #celldeath and leads to development of human #diseases. www.science.org/doi/10.1126/... It was a real joy to work together with @prieto-garcia.bsky.social and all other collaborators. Many thx 👍😀

#ZebrafishMeeting, includes a zebrafish-centric webinar on February 27th, 2025. More details here: events.cancer.gov/dcb/beyond-m...

My first post on bsky - I am proud to share the fruits of a huge collaborative effort spearheaded by the incredible @prieto-garcia.bsky.social published in Science. doi.org/10.1126/scie... Thanks to @idikic.bsky.social for the great experience and for making this happen. Here is what we found 1/3.

I am deeply excited and proud of this paper you have just published in #ScienceMagacine 📗 🧬🧫 It is very commendable . 🎉 I congratulations to all collaborators inside and outside of #IBC2 🤩 Bravo! 🤩 👨🏻‍🔬 @prieto-garcia.bsky.social doi.org/10.1126/scie...

Really nice summary of our work by @mixmue.bsky.social 😀 in her profile. It is amazing to work with you and learn a lot on RNA and splicing! Really thanks for all the help with this project and others that will come ☺️.

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy www.science.org/doi/10.1126/... Great work from @idikic.bsky.social & team! 🧪

Langsame Bearbeitung von Protein-Bauanleitungen führt zu Zelltod. Internationales Forschungsteam unter Federführung der @goetheuni identifiziert Mechanismus, der für größere Genauigkeit bei der Bearbeitung von Proteinvorläufern sorgt. @IB... weiterlesen

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy www.science.org/doi/10.1126/...

Toxicity from cryptic splicing www.science.org/doi/10.1126/...

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...