Very excited for our next seminar this Thursday, March 20th: Martin Schwalm (@thesgc.bsky.social, formerly Knapp lab) will share insights on UPS inhibitors and Dean Clift (TRIMTECH Tx) will discuss hijacking TRIM21 for protein #degradation! 👉Join us at 12 PM EST/ 5 pm CET (‼️ US/EU time mismatch ‼️)

Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation

We got the 3. journal cover. This time depicting the UPS inhibitors interfering with the different steps of the cascade in @acs.org Chemical Biology. pubs.acs.org/toc/acbcct/c...

A photoswitchable HaloTag for spatiotemporal control of fluorescence in living cells by @clairedeo.bsky.social and team: www.biorxiv.org/content/10.1...

Interesting review on TPD which still describes ATTECs as LC3 binding molecules. The paper was revised a month after we published our results that there is no binding to LC3... www.sciencedirect.com/science/arti... See our paper here: www.nature.com/articles/s41...

A rigorous study of UPS tool compounds for #degrader evaluation is published by Stefan Knapp @thesgc.bsky.social in ACS Chemical Biology! They determine the optimal doses of UPS pathway inhibitors that rescue degradation without displaying off-target activity and toxicity. dx.doi.org/10.1021/acsc...

Interested in #TPD? This might be for you. What concentrations of UPS inhibitors are safe to use to prove your proteasome dependent degradation mechanism? #PROTAC #TPD #degradation #Science #drugdiscovery pubs.acs.org/doi/10.1021/...

Great to contribute to this study. We report on a target-hopping approach for the discovery of novel MLK3 inhibitors pubs.acs.org/doi/10.1021/... #KinaseInhibitors #DrugDiscovery #TargetedTherapies

Quality control is often overlooked in novel pathways, and we demonstrate this using ATTECs (Autophagy Tethering Compounds) as a case study. Our new study highlights what’s frequently missing in research! #ProteinDegradation Just out in @naturecomms.bsky.social www.nature.com/articles/s41...

There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...

That awkward moment when someone publishes a paper saying that they can’t find any evidence that your compounds bind to what your own series of papers say that they bind to. . .