Frost lab paper alert! This study was led by Dr. Paul Ramirez, Lead Biostatistician for the Brown University Center for Alzheimer’s Disease Research: alz-journals.onlinelibrary.wiley.com/doi/epdf/10.... 1/9

Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function www.nature.com/articles/s41...

New Frost lab preprint from @SohnClaira: “Elevation of the mechanically-sensitive protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neurons” www.biorxiv.org/content/10.1... 1/9

New Frost Lab Paper/Dataset Alert! bmcgenomics.biomedcentral.com/articles/10.... Congrats to co-first authors @PaulRamirez42 and Dr. Gabbe Zuniga. @carneyinstitute.bsky.social 1/5

We are excited to announce a new open search for a tenure track Assistant Professor position within the Brown University Center for Alzheimer's Disease Research! Apply here: apply.interfolio.com/175427

💫NEW: Sun et al. identify a subset of transposable elements that serve as mechano-response enhancer elements that control #GeneExpression and human #StemCell fate. 👉https://rdcu.be/eJqGP bit.ly/4gYgJjm

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Incredible!!!

Brain on standby — how torpor made ‘tauopathy’ reversible — a Journal Club article by Nina M. Rzechorzek @dynamicbrain.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.

If you are at #AAIC25 and want to see new, unpublished data on #tau, #retrotransposons and circular DNA, check out poster #847 by Morgan Lambert @BrownUniversity from 3:30-4:15 today!

If science in the US ends due to continuous funding cuts, I think I’ll try to join a scientific conference dance troupe. #AAIC2025

1/2 Great article by Amber Dance in @knowablemag.bsky.social, a lay explanation of the @annualreviews.bsky.social that @bessfrost.bsky.social and I wrote about the “retrotransposon storm” hypothesis of Neurodegeneration. knowablemagazine.org/content/arti...

More complete analysis of NIH outlays (or lack thereof) from grant-watch.us grant-watch.us/posts/trends...

The Trump HHS spokesman Andrew Nixon is a flat liar. Peer review selects the best grants and awards them for several years and that’s it. The Trump admin has politicized American science in an unprecedented way and now lies about it. Journalists: ask scientists about what’s happened for the truth.

In case you needed a smile this Tuesday: 10-month-old baby KJ, who received a bespoke gene-editing therapy after a six month scientific sprint - "graduated" from the hospital @childrensphila.bsky.social today and went HOME! YAY SCIENCE! Here's his story: wapo.st/451ZQjT

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

An amazing PhD student in my lab just received notice that her individual F31 fellowship focused on Alzheimer’s disease/Tauopathy was terminated.

Progress with rapid & accessible biomarkers of neurodegeneration! Fujirebio received FDA clearance for a blood assay that predicts amyloid plaque pathology associated with Alzheimer's disease. The assay measures the plasma ratio of pTau217:β-Amyloid1-42. www.fujirebio.com/en-us/news-e... 🧪

The title tells the story and the 5 graphs amplify it www.nature.com/articles/d41...

Does anyone know what kind of jellyfish this is? Spotted on a beach in Narragansett Bay.

NfL beats GFAP in a head-to-head FTD biomarker competition. Gendron et al. show plasma GFAP and NfL correlate with FTD disorder severity; however, NfL outperforms GFAP as a prognostic biomarker and potential susceptibility marker. molecularneurodegeneration.biomedcentral.com/articles/10....

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

Results from our AntiRetroviral Therapy for Alzheimer's Disease (ART-AD) clinical trial are available online today and will be included in the inaugural issue of npj Dementia. rdcu.be/edfwq

One of the NIMH PIs whose name is the termination list: Sooyhun Lee, whose lab just published this beautiful @nature.com paper (that has received too little press because comms at NIH are down). Read! Cite! www.nature.com/articles/s41...

Great write up at @thetransmitter.bsky.social on the seeming erasure of SABV in the new era of NIH. Gotta say The Transmitter is killing it the last few weeks, first to report on the Federal Register block and now this. Leading the charge! 💪 www.thetransmitter.org/policy/exclu...

Guardian article on NIH www.theguardian.com/us-news/2025...

My family knows the pain of Alzheimer’s. It’s devastating. And now we learn Trump’s NIH cuts led to the firing of top researchers working on it --Infuriating. This isn’t “cutting waste”—it’s cutting and gutting life-saving research.

Talk to your neighbors. Talk to your family. Talk to your friends. Tell everyone what is happening and why science matters (this is not a USA-only post, because we know this is happening everywhere)