My grant that I submitted in October finally got assigned to a study section scheduled for May 21. Quite the system we've got going here.

Gotta love a story about a nice Jewish boy listening to the advice of his mother. www.science.org/content/arti...

This is a very carefully worded way of saying that all funding decisions are coming from top from here on out. Also, no more paylines. grants.nih.gov/news-events/...

I sure would like to have time to focus on completing and writing up the actual science. What a silly system we’ve got.

Why on earth would zoom’s default setting be to allow meeting attendees to annotate your shared screen? I gave a public seminar yesterday, and one of the attendees started drawing red lines on the presentation slides 🤦🏻‍♂️. I didn’t even know that was possible.

Bravo. This MIGHT be why. I wish every science joirnalism article framed it this way. theconversation.com/people-who-s...

This quantification of loss is staggering. And knowing some of the excellent people that make up these numbers… is heartbreaking www.science.org/content/arti...

It looks like another government shutdown might be incoming. Which means more study section and council delays, and more scientists holding on by an ever thinning string. But you won’t see many scientists complaining, because I assume most of us agree that Congress needs to try and restrain ICE.

Fully funded PhD programme at Kings College London training researchers to use human genetics AI and multi omics for therapeutic target discovery. Closing date: 28th February www.dementiaresearcher.nihr.ac.uk/job/phd-geno...

This study makes my head hurt. Can a gene variant that’s present in 95% of human beings (APOE3) be considered a risk allele? www.ucl.ac.uk/news/2026/ja...

Apparently 2025 was a big year for APOE4 publications

A powerful maiden speech by my senator, whose dad was recently diagnosed with Alzheimer’s disease. newjerseyglobe.com/congress/in-...

My lab member @arainhirra.bsky.social was saying that she thinks journals should pay scientists to publish their research. I hadn’t really thought about it, but now that I do…why haven’t there been smaller journals that have tried to leapfrog the larger journals by offering to buy high impact work?

APOE-directed therapeutics in AD: My first substack post: open.substack.com/pub/hyassine...

Currently watching Pluribus, and they’ve got their rats in mouse cages. Someone call IACUC.

Love this story (although the headline’s a little misleading). apple.news/A5noSQhLDRdu...

I feel slightly less guilty about using AI to help me write a grant about an AI-based project. But that might be how the machines want me to feel.

While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from @bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...

Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.

In the mood for something sciency and spooky? How about the Halloween special of @uclbrainstories.bsky.social - where me and @caswell.bsky.social talk to @drjlange.bsky.social on some of the gothic stories in neuroscience! 👻 🧠 🎃 💀🧟‍♂️ spotify.link/2lHT9pLQRXb

Don't worry folks! Pretty soon we'll go from having a 0% chance of getting grants (govt shutdown) to having a 5% chance of getting grants (continuing resolution and multi-year funding). But that's only temporary...eventually, it'll go back to the easy-peasy 10-15% funding lines we all know and love.

Very interesting

That's a hell of a figure. www.alzforum.org/news/researc...

Hmm. Reading about oxygen administration for preterm babies and the potential for hyperoxia and oxidative stress, and that is a topic that I’ve heard zero info about up until now.

Pushing through my skepticism to review these K99 and K01 applications I've been assigned. The good news is that there are some tremendous applicants that could contribute so much if given the chance. The bad news is that there's no way to give them a chance if the govt doesn't open back up.

Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects. pubs.acs.org/doi/abs/10.1...

Is it sad that my first thought was: a five year cell culture experiment isn't that bad. There would still be two years left to finish up their PhD or postdoc 😭 😭https://www.alzforum.org/news/research-news/neurons-born-and-raised-organoids-act-their-age

Link to buy below. Even as a 43yo neuroscientist I enjoyed a lot! I mean… who wouldn’ love a book that has monkeys with robot arms & pirate kittens! uk.bookshop.org/p/books/insi...

Currently reviewing grants for a study section that probably won't happen. Whose idea was it to link the success our scientific enterprise with the proper functioning of the federal government?

Tenure-track Investigator Vacancy, Brown University Center for Alzheimer’s Disease Research. Join Carney Institute exploring neurodegeneration and dementia. Closing date: 1st November www.dementiaresearcher.nihr.ac.uk/job/assistan...

PhD position, University of Manchester. Study how APOE genotype, menopause and exercise interact to influence vascular dysfunction and dementia risk in Alzheimer’s. Closing date: 8th November www.dementiaresearcher.nihr.ac.uk/job/phd-alzh...

The 2nd of 6 faculty positions open at UNC Biology is for an Asst Professor studying critical questions in Plant Molecular Biology, focusing on molecular mechanisms illuminating fundamental aspects of plant biology, including interactions with other organisms 1/n unc.peopleadmin.com/postings/307...

Covid causes brain damage. Edit: Covid causes serious long term brain damage, and here's a whole lot more data "COVID-19 infection was associated with a 58% increased risk of all-cause dementia and a 105% increased risk of Vascular Dementia" Free article: www.nature.com/articles/s44...

Rocío is an amazing scientist, mentor, and person in general!!! Please share this job opening with anyone who might be interested 🤩🤩

Posting on behalf of Tamar Gollan, who is not on Bluesky: A postdoc position is open and available immediately in Dr. Tamar Gollan’s Laboratory of Aging Bilingualism at the University of California, San Diego, funded by NIH & NSF. See link for details! psychiatry.ucsd.edu/about/LAB_Go...

Attended a conference yesterday, and one of the speakers spent his whole talk airing his personal grievances about other scientists who he felt had wronged him throughout his career. Made me want to crawl out of my skin.

Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks. Huntington's disease successfully treated for first time www.bbc.com/news/article...

I just read the paper out of Harvard that prompted this tylenol autism announcement. They make a strong argument that acetaminophen use during pregnancy may be causal for neurodevelopmental disorders and that its use should be limited ehjournal.biomedcentral.com/articles/10....

Sadly…and all so that they could meet some arbitrary September deadline that RFK Jr randomly blurted out.

New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com #Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence

Proud to present our new paper in @natmetabolism.nature.com The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases lnkd.in/eVzFrmUY Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).

Can someone who knows this stuff better than I do tell me if Trump’s new $100K H1-B rule applies to non-profits/Universities? I’m assuming no, but probably shouldn’t be assuming anything reasonable anymore.

My awesome Drosophila colleague Akhila Rajan at Fred Hutch (Seattle) is recruiting both a staff scientist and a postdoc to study fat–brain communication, innate immunity, mitochondrial signaling, and brain senescence. Great team, great environment. Apply here: careers-fhcrc.icims.com/jobs/30062/j...

Nixon Lab is hoping to recruit a postdoctoral fellow interested in alcohol-microglia and/or alcohol-neural stem cell interactions in recovery from alcohol-induced brain and behavioral damage/dysfunction. Open fellowships on our NIAAA-funded T32! Please spread the word!

Calling for your paper for the upcoming collection Brain metabolomics in dementia and neurological disease I’m honoured to be serving as the collection’s Guest Editor and eager to read your submission. #CallForPapers @natureportfolio.nature.com Learn more about the collection: go.nature.com/41S5bI3

I don’t know if it’s overall a good thing or a bad thing for science, but I have to say…the papers I review now are a hell of a lot clearer and easier to read than they were before chatGPT was invented. Which honestly, I don’t mind.

For anyone on the neuroscience job market, our ads are up. We are looking for anyone working in systems neuroscience of animals to join us in southern Alberta 🇨🇦 #academicsky #neuroskyence #neuroethology #academicjobs #Canada neurojobs.sfn.org/job/39049/as...

It will never not annoy me that the first Republican government to take a real interest in changing the way science is done were the misinformation, burn it all down Republicans, and not the let's remove government regulations to increase productivity Republicans.

Good news! Although definitely not the end of the fight on this. Hopefully the government will be forced to unfreeze all the research funding while the case works its way up to the Supreme Court. www.cnn.com/2025/09/03/p...