In this preprint, the main consortia working on Alzheimer GWAS combined their efforts to validate an detect new loci associated with AD risk. We observed 91 genome-wide significant signals (16 nove) . Among these 91 loci, 56 of them are specifically detected in clinically diagnosed AD cases.

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social‬ as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease” Join the network or DM for more info

In this preprint led by Devrim Kilinc and Pierre Dourlen, we observed that differential expression of BIN1 isoforms in the presynaptic part leads to differential synaptotoxicity. BIN1 isoforms could contribute to the synaptic loss observed in Alzheimer's disease. www.biorxiv.org/content/10.1...

In this preprint, primarily conducted by Dolores Siedlecki, we established a neuron-microglia co-culture model within the synaptic chamber of a microfluidic device. This compartmented approach enables us to study synapse phagocytosis in close proximity to microglia. www.biorxiv.org/content/10.1...

Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community. reeserichardson.blog/2025/08/04/a...

In this new EADB preprint led by Ole Andreassen, we present an improved polygenic hazard score model for AD that demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models. www.medrxiv.org/content/10.1...

Happy cat on my belly

A new EADB paper published in Nature Communications and led by Kristel Van Steen, Cornelia Van Duijn and Valentina Escott-Price. We report that machine learning methods have the potential to uncover novel loci that remain undetected by traditional GWAS in Alzheimer. www.nature.com/articles/s41...

FromFB: 😂

Finally out in Nature genetics ! A long journey to have this paper published. Led by my team, under the EADB umbrella (eadb.eu), the project involved numerous partners worldwide in assessing the genetic complexity of Alzheimer in populations of diverse ancestries. www.nature.com/articles/s41...

Trump’s cuts to more than 1700 #NIH grants get court hearing www.science.org/content/arti... by @sarareardon.bsky.social @science.org #Alzheimers #dementia #neuroscience #science

This is a cumulative maximum intensity projection movie of the endoplasmic reticulum labeled with the membrane marker mEmerald-Sec61B.

Announcing an official fundraising campaign to support my lab’s research on APOE4 and Alzheimer’s disease: joinus.cuimc.columbia.edu/participant/.... This campaign is itself an experiment of sorts. But mostly, it's an attempt to save my lab during an unprecedented time of turmoil in academia. 1/9

Here is a direct link to the open access article ‪@amit-das.bsky.social‬ mentions. alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Tempting to say it feels like a miracle, but this progress always comes down to dedicated study participants, brilliant scientists, and reliably funded science.

I went in search of cygnets. Still not hatched so had to make do with a heron fishing instead. Look at those feet! #UKWildlife #UKbirding #Birds #Photography #Nature #GreyHeron #photographersunited #PhotographersofBluesky #Sonyalpha

Currently visiting the Medieval Museum in Barcelona. This was painted in 1210…

In this report, to improve our understanding of the genetic architecture of AD in the context of its main genetic driver, the EADB consortium and collaborators performed the largest global genome-wide association studies stratified by ε4 and ε2 carrier status. www.medrxiv.org/content/10.1...

And definitively accepted after more than a month of editing to meet all the publisher's requirements.

'BIN1 and Alzheimer’s disease: the tau connection' by Pierre Dourlen, Devrim Kilinc, Isabelle Landrieu, Julien Chapuis & Jean-Charles Lambert @jclambert.bsky.social www.cell.com/trends/neuro...

When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years. www.sciencedirect.com/science/arti...

Quick guide to understand your cat

am pleased to share our letter, highlighting that the science does not yet support regulatory approval of amyloid-targeting therapies for AD based solely on biomarker evidence. alz-journals.onlinelibrary.wiley.com/doi/full/10....

She's 8 years old and it sometimes seems like she still looks like a teenage cat. Admittedly, she's a very small size

Join us at @pasteurlille.bsky.social ! We're hiring a Facility Manager specializing in human iPSCs, organoids, and organ-on-chip technologies. Drive innovation in cutting-edge biomedical research. Apply now! Contact Dr Alexandre Grassart #CDP @univlille.bsky.social @cnrs-hautsdefrance.bsky.social

📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣 Plus d'infos sur le mouvement 👉 standupforscience.fr #pasteurlille

French Senator Claude Malhuret: "Washington has become Nero’s court, with an incendiary emperor, submissive courtiers and a jester high on ketamine... We were at war with a dictator, we are now at war with a dictator backed by a traitor."

Il y a quelques temp, j’avais vu un message de @damienbarraudmd.bsky.social à propos de la serie “The Pitt”…J’ai commencé à la regarder. Je ne peux juger de sa veracité mais elle a quelque chose en plus je trouve … une vraie humanité et une certaine forme de simplicité (bon c’est quand même un show)

Finally accepted “in principle” In Nature Genetics … 18 months of hard works because of massive revisions (that strongly improved the manuscript to be honest). A long journey finally successful. What a relief …

Zelensky is a wartime leader watching his people suffer and die under Russian attacks every day. To be lectured and lied to by Trump and Vance, as they defend the war criminal dictator committing these atrocities, is unimaginable agony. An everlasting shame for America.

Dear American friends I'm not sure you realise what a disaster we have just witnessed today. The US is on Russia's side, and we have understood this once and for all A page has probably been turned between Europe and the USA It is a sad day

1/ NEW: Lecanemab in France The French Federation of Memory Clinics just released its appropriate use recommendations for #Lecanemab in early #Alzheimers. What’s new? How does it compare to U.S. guidelines? A thread 🧵⬇️ www.sciencedirect.com/science/arti...

Daily reminder of who Musk is:

Alzheimer's research funding is in the DOGE crosshairs, putting invaluable datasets (including tens of thousands of genomes) and biorepositories at risk. This reflects the volunteer efforts of thousands of research participants over four decades. Please contact your reps/senators. Hands off NIH.

Portuguese editorial cartoonist Zez Vaz reaches back to Tiananmen Square to call on American defiance.

Received today I'll read it with interest ... probably unfair to the vast majority of researchers who are doing their best to understand and cure Alzheimer's disease. A few black sheep mar the constant, relentless efforts of a community that is aware of what is at stake.

My annual Valentine’s post of this image that happens to land on #FluorescenceFriday this year! An axon approaching a kidney glomerulus doing its best to look like a rose.

Exciting news! Our paper on GWAS gene prioritization for Creutzfeldt-Jakob Disease is now published in Brain! 🧠🧬 @brain1878.bsky.social We leverage eQTL and pQTL catalogues to identify prioritized risk genes with potential roles in prion disease. Check it out here: academic.oup.com/brain/advanc...

It is my great pleasure to announce the launch of the European Alzheimer & Dementia Biobank website! This site has been designed to present our work, our organisation and to encourage collaborations. Do not hesitate to contact us! eadb.eu

Very happy to see our review on Alzheimer's disease rare genetic variants published in @natrevneurol.bsky.social! 🧠🧬 Huge congrats to our PhD student @laradedeyn.bsky.social 🎉👏✨ www.nature.com/articles/s41...

Je ne pense pas que les deux points de vue soient antonymes. Ils ne décrivent pas les mêmes champs de discussions. La science et la démarche scientifique ont pour objectif d’établir une hypothèse puis une théorie pour expliquer des faits observés, mesurés, reproduits et donc établis.

The US Centers for Disease Control and Prevention (CDC) has mandated that all scientific manuscripts produced by its researchers that are under review at a journal be withdrawn so that certain language relating to gender can be stripped from them. https://go.nature.com/40YJGp4

Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed

« La science a fait de nous des Dieux, avant même que nous soyons dignes d'être des hommes. » « Science has made us gods, even before we were worthy of being men. » Jean Rostand, biologist and science historian

This morning I saw a panel of editorialists/gusets on a French news channel (@lciofficiel.bsky.social). They were completely fascinated by Trump, and completely detached from the impact of the current decisions. A lack of perspective without taking into account the feedback/fairs of many Americans.

I compared ChatGT 4o mini and Deepseek on a specific scientific question about Alzheimer, which I know very well, and also asked for references. Deepseek's superiority is clear: more precise and the right references. On the reassuring side, I'm still better but I've spent years working on this :o)

Many French editorialists believe that Munsk doesn't really have an ideology and that his support for the far right is just opportunism for his own business, with the aim of destabilizing the EU and its standards... seems naïve to me. He can be far-right and favor his business. Two birds, one stone

Revision submitted last Friday and sent back for review 😔 I was really hoping for a quick and positive answer from the editor … Clearly less confident at present