inquiSTR: a toolkit for accurate and efficient population-scale tandem repeat genotyping and analysis https://www.biorxiv.org/content/10.64898/2026.06.09.731080v1

Out now in @natgenet.nature.com! Our latest GWAS meta-analysis identifies 91 risk loci for Alzheimer’s, deeply expanding our understanding of its genetic architecture. Proud of our team's contribution to this massive milestone! 🧠🧬🔬 @maegsul.bsky.social doi.org/10.1038/s415...

What a huge effort by Anneleen Decock and Annelien Morlion from the OncoRNALab (@jvdesomp.bsky.social and Pieter Mestdagh), meticulously documenting a completely reproducible exRNA sequencing protocol. www.cell.com/star-protoco...

Last Friday, the KS Lab attended the Stop Alzheimer (SAO) Young Researcher Congress in Mechelen 🧠 During the event, Fahri Küçükali gave an oral presentation and Nicole Natalia Wawrzyniak presented a poster. 📊 Once again, we thank SAO for their continued support of Alzheimer's research in Belgium!

Happy and honoured to receive the Fabrizio Caielli Award from the Carlo Besta Neurological Institute for our recent publication, “Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes” 🧠🧬 Many thanks to the selection committee for this recognition. 🔗 tinyurl.com/5y7nwp34

Through the Flemish Cognitive Compass, we can link genetic profiles with blood biomarkers and long-term follow-up at population level. Thankful for the opportunity to contribute to such a collaborative and forward-looking effort!

Over the past months, we have mentioned our 1000 Healthy Elderly study quite often. This article puts the study in the perspective of the most important people in our study: the participants 🧓 biovox.eu/before-the-f...

Extremely thankful to have our Senior Research Project (with Julie van der Zee and @verwilt.bsky.social) funded in this @fwovlaanderen.bsky.social call! This marks a huge investment into our 1000 Healthy Elderly study in search of novel cell-free biomarkers! 🧠🧬🩸

HIRING ALERT!!! 💥 We are looking for an enthusiastic postdoctoral researcher to uncover Alzheimer's disease mechanisms using state-of-the-art technologies! 🧠🧬 jobs.vib.be/j/128109/pos...

Last Friday, we shared our research with 1st year Master's students at @uantwerpen.be during the Research Day! We loved their genuine interest and look forward to welcoming several of them to our lab next year. Great to see Ph.D. students Kato and Ella share their love for science! 🧪

The European Alzheimer & Dementia Biobank (EADB) unites cohorts across 18 countries to decode the genetics of Alzheimer’s disease. https://eadb.eu/ At CMN, the @sleegerslab.bsky.social plays a leading role, with postdoc Fahri Küçükali as our in-house EADB specialist. #CMNcohorts #CMNconsortia

One year in, nearly 200 re-inclusions and a clearer picture of healthy brain aging! The 1000 Healthy Elderly Study has become a real engine for discovery. Thanks to all of our volunteers and a special shout-out to Sofie Van de kerckhoven for the excellence at intake and sampling! bit.ly/4gV9TLk

🚨 #PhD opportunity! Sleegers & Rademakers Labs are looking for a PhD candidate to develop biomarkers for neurological disorders by integrating genomics & transcriptomics data🧠🔬 @cmn-vib.bsky.social 📍 Antwerp, Belgium | 💡 Genetics • Bioinformatics • Neuroscience Apply 👉 jobs.vib.be/j/124544/joi...

🌪️ Storm aan talent op komst: ontdek de selectie van de Vlaamse #PhDCup 2025 🏆 Lees meer en ontdek alle kandidaten 👉 www.phdcup.be/nieuws/storm... @uantwerpen.be @kuleuvenuniversity.bsky.social #uhasselt #ugent #vub @fwovlaanderen.bsky.social

Our postdoc @verwilt.bsky.social is selected for the @scimingo.bsky.social PhD Cup for his research during his PhD! 💥 Let's see how his findings can impact Alzheimer's Disease 🧠🧬🩸 @fwovlaanderen.bsky.social @ugent-fge.bsky.social @cmn-vib.bsky.social @viblifesciences.bsky.social @uantwerpen.be

Over the moon to be selected for the Flemish #PhDCup 2025 for my research at @ugent-fge.bsky.social at the OncoRNALab with @jvdesomp.bsky.social and Pieter Mestdagh! @fwovlaanderen.bsky.social

Big congrats to @verwilt.bsky.social‬ from the @sleegerslab.bsky.social‬ on his FWO fellowship! He’ll be mapping RNA and DNA in blood, CSF, even tear fluid, to develop non-invasive biomarkers for Alzheimer’s using long-read sequencing. https://tinyurl.com/ym6c8csr

Ciao Milano! We are happy and excited to be here for #eshg2025 @eshg.bsky.social Come find us during the oral and poster presentations by our team members Fahri Küçükali (@maegsul.bsky.social) & Celeste Laureyssen (@celestelaureyssen.bsky.social) today and tomorrow 🧬 🧠

What a poster! Master’s student in our lab, Kato Nauwelaers, won third prize for her poster at NeuroDay 2025 @uantwerpen.be! Congrats Kato! 🎉

Look at us! 🤩 We presented the excuting research going on in our lab at the @uantwerpen.be NeuroDay 2025. So great to with fellow neuroscientist! 🧠

A new chapter in our lab has begun! Our postdoc @verwilt.bsky.social has received an FWO Junior Fellowship to look for non-invasive extracellular biomarkers for Alzheimer’s disease. Stay tuned for some cool research! @fwovlaanderen.bsky.social

YOU MUST BE KIDDING ME! 🥳 Extremely happy to be selected as a Junior FWO Postdoctoral fellowship! Stay tuned for novel extracellular biomarkers for Alzheimer’s disease! Can’t wait to jump in these three years! 🧠🩸🧬 #fwo #RNA #cfDNA #alzheimers @fwovlaanderen.bsky.social @sleegerslab.bsky.social

7 years in the making... 1.6 liters of blood and 11 billion sequencing reads to compare 456 extracellular transcriptomes. Our best practices for blood plasma extracellular RNA profiling have been published as a peer-reviewed article. communities.springernature.com/posts/the-ro...

Finally out! The exRNAQC Consortium is very happy to present this milestone benchmark on blood tubes and RNA extraction kits for extracellular RNA research out in @natcomms.nature.com! The associated blog post tells a story of a lengthy effort and multi-facetted collaboration🩸🧬

Our lab’s recent hackathon ☕🧠💻 was a success: three packed days, one awesome crew, endless ideas. We built fresh neurogenomics tools and leveled-up team vibes 🚀🧬

🚨 PhD Position Alert! 🚨 We're excited to announce a collaborative PhD opportunity with @uantwerpen.be LEMP, investigating the role of mucin splicing in colorectal cancer. If you're passionate about RNA biology, omics, and translational research, this could be the perfect fit!

Exciting news! Our paper on GWAS gene prioritization for Creutzfeldt-Jakob Disease is now published in Brain! 🧠🧬 @brain1878.bsky.social We leverage eQTL and pQTL catalogues to identify prioritized risk genes with potential roles in prion disease. Check it out here: academic.oup.com/brain/advanc...

New paper on risk genes for sporadic CJD academic.oup.com/brain/advanc...

Very happy to see our review on Alzheimer's disease rare genetic variants published in @natrevneurol.bsky.social! 🧠🧬 Huge congrats to our PhD student @laradedeyn.bsky.social 🎉👏✨ www.nature.com/articles/s41...

New online! The impact of rare genetic variants on Alzheimer disease https://bit.ly/4hntQtT

From tears to AD biomarkers! @verwilt.bsky.social recently received a 10.000 euro @uantwerpen.bsky.social BOF KP grant to kickstart our research on the biomarker potential of tear fluid RNA in AD! 🥲🧬

We have an open position for a PhD student to look for new #biomarkers for #epilepsy and #alzheimersdisease in blood/serum, cerebrospinal fluid, and brain tissue samples. 📈 🩸 🧠 A joint position in the @sleegerslab.bsky.social and Weckhuysen lab. All info 👉 cmn.sites.vib.be/en/join-us#/...

💼💥Ph.D. JOB ALERT!!! Together with the lab of Prof. Weckhuysen, we are looking for a motivated Ph.D. student 🧑‍🎓 to explore the wonders of liquid biopsies and help diagnosing Alzheimer's disease and epilepsy patients 🧠🩸

🧠 New insights into the genetic factors that drive Alzheimer’s disease 👉 Read here: vibbio.tech/4izHlYc 🔬 Study led by Prof. Kristel Sleegers of VIB-UAntwerp Center for Molecular Neurology @uantwerpen.bsky.social @alzassociation.bsky.social

Finally out! X‐chromosome-wide association study for Alzheimer. Our new EADB work led by Celine Bellenguez in collaboration with GR@ACE, DEGESCO, EADI, GERAD, DemGene, FinnGen, ADGC and CHARGE. We identified seven X-chromosome-wide significant loci that need further validation. rdcu.be/d2tWv

🤝 Marieke Vromman ⭕️🧬 Very happy to share that our review on extracellular circRNAs is now out in WIREs RNA! We summarize the little that is known, navigate their daunting literature, and dive into hypotheses on their extracellular existence! wires.onlinelibrary.wiley.com/doi/epdf/10....

For the FFBD Faculty Research day, the @UAntwerpen interviewed our Ph.D. student @CelesteLaureys1 on her work on the genetic exploration of Alzheimer’s disease hallmarks . Listen to her explain her research! 🧠🧬https://open.spotify.com/episode/0isr8pKJq9w0GqLJpgrn7n?si=-05SPAOTQHKWZ34_FTIFDQ

We are excited to share that our new paper, led by Celeste Laureyssen, is now published in Acta Neuropathologica and available online!🧠🧬 Check out our new publication here: link.springer.com/article/10.1...

Talking long reads in Uppsala! Find the ever-enthusiastic Tijs Watzeels at his poster where he will draw you into the world of differential isoform usage in AD! 🧠🧬 #LRUA24

The last few days, one of our Ph.D. students Celeste Laureyssen presented a poster on her research at ECDO Conference focusing on “Cell Death at the Crossroads of Neurodegeneration and Cancer". Stay tuned for the follow-up paper soon to be published! 🥳🧐#ECDO2024

Very happy to see our new paper on our new tool for comprehensive analysis of single-cell RNA long-reads, 𝙨𝙘𝙮𝙬𝙖𝙡𝙠𝙚𝙧, published! 🧬 If you have any long-read single-cell datasets, give it a try! Paper: academic.oup.com/bioinformati... GitHub: github.com/derijkp/scyw...

Happy and excited to be in Philly for #AAIC24! Come find us during the oral and poster presentations by our team members Lara De Deyn, Celeste Laureyssen, and Fahri Küçükali (@maegsul.bsky.social) on our recent work! 🧠🧬

Exciting news! Yesterday, we were honored to receive a generous grant from Stichting Alzheimer Onderzoek! This grant is a crucial step forward for our Alzheimer's research as we'll be delving into the intricacies of the ABCA7 gene, a risk factor in AD 🧠🧬 Thanks to everyone involved!

New review out! Let Lena Duchateau, Nicole Wawrzyniak, and Kristel Seegers guide you through the mysterious world of ABCA7!

Good morning #Tau2024! Come say hi to Celeste Laureyssen who is presenting her poster, "Genetic variation in APH1B is associated with tau-related brain lesions observed in Alzheimer's disease", poster board 31 today! 🧬🧠 www.alz.org/tau/overview... #Tau2024

We are happy and excited to be in Lisbon this week for #ADPD2024! Come check out these posters by our great team about their latest results on genetic and transcriptomic analyses of Alzheimer's disease.

Scywalker: scalable end-to-end data analysis workflow for nanopore single-cell transcriptome sequencing https://www.biorxiv.org/content/10.1101/2024.02.22.581508v1