Last week, I had the honour to deliver my @uclqsion.bsky.social professorial inaugural lecture. A memorable occasion to reflect about my career and thank amazing people who supported me in many ways. I look forward to exciting research ahead! #epigenetics #omics #neurodegeneration #dementia #ageing

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social‬ as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease” Join the network or DM for more info

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social‬ as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease” Join the network or DM for more info

#Multiomics approaches are enabling the decoding of the impact of non-coding variants and of disease-associated molecular dysregulation. Hear from @saobettencourt.bsky.social and Andrew Stergachis TODAY in Webinar 1 of the Multi-Omics Online series. Register now: hubs.la/Q03wC2FL0

UCL Queen Square Institute of Neurology ready to (platform) party this morning! @uclqsion.bsky.social Huge congratulations to all of our graduates from the @uclbrainscience.bsky.social & wishing you all every success for the future! #UCLgrad

Discover how #multiomics is transforming disease research! Our new webinar series, Multi-Omics Online, showcases the latest advances from foundational science to clinical application. Register now to find out what’s working, what’s not, and what’s new. Register here: hubs.la/Q03wC2D50

🚨New publication alert from the #BettencourtLab! Naiomi Rambarack's first first-author paper 👏 : #DNAmethylation #dysregulation of #STX6 and other #FTLD #genetic risk-associated loci". #Dementia Big thanks to all contributors and funders! @alzheimersresearchuk.org rdcu.be/euZmw

🚨Join our next @Deep #Dementia Phenotyping (DEMON) Network #Genetics and #Omics meeting on THURSDAY 10th July at 2.30 PM (UK Time). Delighted to have @billingsleykj.bsky.social as invited speaker – “Decoding the Genomics of Neurodegenerative Diseases with Large-Scale Long-Read Sequencing”.

New paper from the lab, under the leadership of @celarber.bsky.social !

External link live! Please share widely :-) WE ARE RECRUITING! 🥳 Are you an epidemiologist with strong quantitative skills and an interest in contributing to exciting research into the genetic architecture of vascular dementia? Come join our friendly and productive team at UCL! shorturl.at/aZ5Ua

Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 12th June @2.30 PM (UK Time). Delighted to have María Beatriz Bistué Millón and Fulya Akcimen as invited speakers – “Characterization of short tandem repeat expansions in dementia across Latin American populations”. DM for +info

How does the brain repair myelin after injury? We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination. www.biorxiv.org/content/10.1... Details below 👇

Excited to be presenting our work on #Epigenomics of #Tauopathies and related diseases later this week at #Tau2025👇!

Our paper just came out in Cell Reports, thank you to everyone that contributed! Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation: Cell Reports www.cell.com/cell-reports...

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 10th April at 2.30 PM (UK Time). Delighted to have Faraz Faghri as invited speaker – “AI for Discovery: Applications in #Biomedicine and #Brain #Health”. Join the network or DM for more info

Dr Imre Lengyel @imrelengyel1963.bsky.social at Queen's University Belfast is seeking a PhD Student to explore 'Revolutionizing MS and Alzheimer’s Monitoring: The Role of Retinal Imaging in Understanding Disease Progression'. Closing date: 8th April www.dementiaresearcher.nihr.ac.uk/job/phd-the-...

🚨 It's been a very important day to the #BettencourtLab. Congratulations Dr Katherine Fodder 🥳🥂! Proud PhD supervisor here! It's been a pleasure to work with you during this journey. Thank you so much to both examiners Emma Dempster and Simon Mead ! ☺️

www.biorxiv.org/content/10.1... New work from Humphrey and Raj labs, exploring the role of RNA editing in myeloid cells. Hopefully will be a useful resource for the field. Next stop: genetics!

The #BettencourtLab had a great time at #Epigenomics25 🧬. Naiomi Rambarack, Katherine Fodder and Hannah Smith did an amazing job at presenting our work on #epigenetics of #dementias 🧠. It was great to network and get inspiration from experts from around the 🌎. #DNAmethylation #FTD #Alzheimers

The first comprehensive atlas of allele-specific DNA methylation www.nature.com/articles/s41...

Join us tomorrow 👇 #Genetics #Omics #Parkinsons #Epistasis

🚨Join our next @DEMONNetworkUK Genetics and Omics meeting on THURSDAY 6th March at 2.30 PM (UK Time). Delighted to have Alejandro Cisterna as invited speaker – “Detecting epistasis in Parkinson’s Disease using VARI3” Join the network or DM for more info #Dementia #Genetics #Omics #Parkinsons

Had a brilliant time at #ARUKConf25! Came back full of inspiration. Highlights – inspirational story of lived experience by Jordan #TheFTDBrothers, latest updates on omics, biomarkers, treatments, and so much more on ongoing #dementia #research. #ForACure @alzheimersresearchuk.org

Neuronal polyunsaturated fatty acids are protective in ALS/FTD www.nature.com/articles/s41...

Lipid metabolism, remodelling and intercellular transfer in the CNS — a Review by Sam Vanherle, Melanie Loix, Veronique E. Miron, Jerome J. A. Hendriks & Jeroen F. J. Bogie @mironlab.bsky.social @jeromehendriks.bsky.social @jeroenbogie.bsky.social www.nature.com/articles/s41...

The UCL Genetic Therapy Accelerator Centre @uclqsion.bsky.social is seeking a Research Assistant to work on translational AAV gene therapy project for Parkinson working with Professor Joanne Ng. Closing date: 2nd March. www.dementiaresearcher.nihr.ac.uk/job/research...

Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity https://www.biorxiv.org/content/10.1101/2025.02.14.637261v1

Huh, wild. A new potential driver of AD pathology? RAN-translated peptides in Alzheimer's disease: www.pnas.org/doi/10.1073/...

Researchers "introduce a novel multimodal progression framework that integrates, for the first time, the temporal & spatial progression of astrocytic & oligodendrocytic α-synuclein pathology alongside neuronal pathology in #Parkinsons" actaneurocomms.biomedcentral.com/articles/10....

Dr Nurun Fancy at Imperial College London @imperialcollegeldn.bsky.social is seeking a PhD Student to explore the role of LRRK2 in cellular senescence in Parkinson's Disease. Closing date: 15th March #PhDPosition www.dementiaresearcher.nihr.ac.uk/job/phd-role...

Exciting news! Our latest paper is out today in @ScienceTM — 'Antisense oligonucleotide–mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington’s disease iPSC–derived striatal neurons' 🧬 www.science.org/doi/10.1126/... @uclqsion.bsky.social @uclbrainscience.bsky.social

Professor Siddharthan Chandran at The University of Edinburgh is seeking a Postdoc Fellow to work on understanding the biology of MND for Drug Discovery. Closing date: 28th February. www.dementiaresearcher.nihr.ac.uk/job/postdoct...

A first description of the C9 repeat iNDI lines is now on bioRxiv, a collaboration from genome engineering through cell biology to facilitate ALS/FTD research @michael-e-ward.bsky.social @jacksonlab.bsky.social @cziscience.bsky.social www.biorxiv.org/content/10.1...

ICYMI: New online! The impact of rare genetic variants on Alzheimer disease https://bit.ly/4gzuumP

🧠🔬Cool study by @lidazoupi.bsky.social and colleagues!🧪🧩 📍The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes onlinelibrary.wiley.com/doi/full/10....

Any UK pre-clinical stroke researchers out there? Join us for our meeting in September at Keble College in Oxford! 🧪 www.ndcn.ox.ac.uk/study-with-u...

Cool!! 💥Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis💥 by Qiang Ma and colleagues #neuroskyence #neurosky #oligodendrocytes #Parkinson’s www.cell.com/cell-reports...

🚨Join our next DEMON Network #Genetics and #Omics meeting on THURSDAY 13th February at 2.30 PM (UK Time). Delighted to have @billingsleykj.bsky.social as invited speaker – “Decoding the genomics of Neurodegeneration in global populations using large-scale Long read sequencing”. DM for more info!

Last week was a busy week for the #BettencourtLab, attending the Festival of Genomics and Biodata 2025, the BNS conference 2025 and much more. Great presentations from the team by Naiomi Rambarack and Kate Fodder 😊! And lots more to celebrate 🥂. #epigenetics #DNAmethylation #dementia #FTD #Alzheimer

🚨 New preprint from the #BettencourtLab by Rambarack et al 👇. #epigenetics #DNAmethylation #FTD #PSP #FTLD #dementia

Vacancy for a Senior Research Technician to join Professor Sarah Tabrizi’s research group at UCL to provide maternity cover at the Huntington’s Disease Centre. Closing date: 12th February www.dementiaresearcher.nihr.ac.uk/job/senior-r...