It was a pleasure to host @marcaurelbusche.bsky.social for a special UK DRI webinar last week on how circuits fail in Alzheimer's disease, and hear about his lab's recent incredible findings 🧠 If you missed it, catch up here 👇 youtu.be/JzPFyO4ef-I?...

🧠 How do brain circuits fail in early Alzheimer's disease? 🧠 Join @marcaurelbusche.bsky.social for the next research webinar in our 'Rethinking neurodegeneration' series, taking place 4-5pm (BST), Thurs 24 July 🗓️ 🚨 Register for free today! 🚨 Full info 👉 www.ukdri.ac.uk/events/rethi...

I‘m excited to speak at this UK DRI webinar “Rethinking Neurodegeneration” on 24 July, discussing cell type- and circuit-specific vulnerability in early Alzheimer’s. #Alzheimers #Neurodegeneration #UKDRI

Research led by @marcaurelbusche.bsky.social and Dr Samuel Harris (@uclqsion.bsky.social & @ukdri.ac.uk) has discovered that the amyloid precursor protein (APP) family is essential for healthy communication between brain cells.

Research led by Dr Samuel Harris and @marcaurelbusche.bsky.social reveals a role for the Alzheimer's-linked APP proteins in sustaining brain activity in healthy brains 🧠 The study provides insight into how their disruption could contribute to cognitive impairments👉https://buff.ly/KcwK7OQ

Closing date is June 12th - please do apply in case of interest!

It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week. www.nature.com/articles/s42...

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments. Apply here👇 shorturl.at/LpCAq

A study led by Dr @marcaurelbusche.bsky.social (@uclqsion.bsky.social, @ukdri.ac.uk) sheds light on the earliest stage of Alzheimer’s, identifying which layers and cell types of the brain are first affected.

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments. Apply here👇 shorturl.at/LpCAq

New research by @marcaurelbusche.bsky.social identifies where Alzheimer's begins in the brain, revealing which layers and cell types of the brain are first affected 🧠 The study opens up potential new pathways for targeted therapies👉https://buff.ly/4GlltQF

Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2. www.cell.com/neuron/fullt...

Impressive research. We are proud to support your work!

Delighted to have played a part in this work, now out in @cellpress.bsky.social, where we show how soluble high molecular weight tau from Alzheimer’s brain suppresses burst firing in hippocampal neurons.

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory. www.cell.com/cell/fulltex...

New research led by @marcaurelbusche.bsky.social has found that tau specifically disrupts a certain type of electrical activity in the hippocampus in Alzheimer's🧠 The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6

Stelle als Oberärztin/Oberarzt: An der Universitären Altersmedizin FELIX PLATTER in Basel entsteht eine interdisziplinäre Verbindung von Klinik, Diagnostik und translationaler Forschung in Demenz/Alterspsychiatrie. Jetzt aktiv mitgestalten. www.felixplatter.ch/felixplatter...

Delighted to see the Synapsis Foundation & Race Against Dementia investing in the next generation of dementia researchers! Hopefully just a start of a growing UK-Swiss collaboration in this very important area.

Delighted to see this news! Rikesh is an outstanding colleague - creative, dedicated, and absolutely committed to the fight against dementia. He will be a tremendous asset to the new BHF-UK DRI Centre. Wishing him every success - they couldn’t have picked a better person!

Link to British dementia work with @selinawray.bsky.social : link.springer.com/article/10.1... Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...

On my way to UCL to give a seminar on all things #tau and #iPSC! Looking forward to hanging out with the @marcaurelbusche.bsky.social and @selinawray.bsky.social labs 😊 Struggling with my enormous Edinburgh-weather-appropriate but London-inappropriate coat on the Piccadilly line though 🫣