Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich: Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits. doi.org/10.1007/s002...

Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques www.medrxiv.org/content/10.1...

New paper alert: A two-cutoff CSF Aβ42/40 approach improves Aβ detection in real world clinical settings. CSF Aβ42/40≥7.1 rules out amyloid, while ratios~5.5–7.1 benefit from Aβ PET. Key for Lecanemab stratification. #Alzheimers #Biomarkers 📄read more: doi.org/10.1002/dad2...

Happy to share our new work led by Johannes Gnörich and Matthias Brendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key! doi.org/10.1016/j.ne...

Happy to share Davina Biels newest work in @embomolmed.bsky.social, showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women Many thanks also to co-senior Matthias Brendel!

Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP doi.org/10.1007/s004...