NPH is real, it’s common, and it’s treatable! #NPH #endalz www.nejm.org/doi/full/10....

NPH is common and reversible cause of dementia symptoms. It’s obviously cost effective for health systems to prioritize proper diagnosis and treatment of all patients presenting with cognitive decline. doi.org/10.1212/WN9....

This was so much fun to do with @renegadesynapse.bsky.social #neurology @greenjournal.bsky.social #endalz #fdgforall youtu.be/GTOzwUALePM

Electromagnetic waves enable low-energy, parallel computation. Your brain has them. If humans can figure this out, 4 billion years of evolution could too. Programmable wave-based analog computing machine: a metastructure that designs metastructures www.nature.com/articles/s41... #neuroscience

🚨Pre-print alert🚨 We stimulated serotonin with optogenetics while doing large-scale Neuropixel recordings across the mouse brain. We found strong widespread modulation of neural activity, but no effect on the choices of the mouse 🐭 How is this possible? Strap in! (1/9) 👇🧵 doi.org/10.1101/2025...

1/ Every week in my neurology clinic, I see people lost in the search for a diagnosis. Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years. We just published a new AI tool to change that. Here's why it matters🧵 @mayoclinic.org #ENDAlz

A new AI tool can identify nine types of dementia from a single FDG-PET brain scan, supporting faster and more accurate diagnosis, even in clinics without neurology specialists. doi.org/g9rnhp

"The work we reviewed here supports an alternative view that the manifold and circuit approaches to cognition are inseparable." Can I get an amen? 😊 www.nature.com/articles/s41...

🚨 Video alert: I was able to share our @mayoclinic.org work on #NeuroAI at #GoogleCloudNext, including how we hope to scale expert interpretation of brain scans to improve dementia care. 🧠 Watch here: youtu.be/lJ1SVeeFWZQ?... #DigitalHealth #AI #endalz

Discovery funded by 3 NIH grants:

Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️ link.springer.com/article/10.1... @drchristinamoloney.bsky.social @davidjonesbrain.bsky.social

Amazing group @maggieflanagan.bsky.social @gokcegroup.bsky.social @leatgrinberg.bsky.social @hillmanlab.bsky.social @davidjonesbrain.bsky.social @alifiyakapasi.bsky.social @karchlab.bsky.social @tammarynlashley.bsky.social @tnrlab.bsky.social @tspiresjones.bsky.social @ionicwoman.bsky.social

A big thank you to all those who have been so positive about my new book. It's about how neurological patients can tell us so much about our selves, how personal and social identities are forged by different cognitive functions, and what it means to belong.

Multiple pathological processes appear to have contributed to the hippocampal atrophy and hypometabolism in a patient that has taught me so much about limbic-predominant amnestic neurodegeneration: doi.org/10.1111/neup...

The agents are coming! ‘Digital humans’ in a virtual world www.thetransmitter.org/neuroai/digi... cc @thetransmitter.bsky.social

Epistemic failure of the current paradigm is an epistemic pump that drives the next paradigm!

“The connection between amyloid-β and tau pathology appears to be disrupted in this individual…” The connection is functional, and the function is preserved in this case. www.nature.com/articles/s41...

I made some edits for people who think behavioral neurology should focus more on proteins then behavior:

Episodic and associative memory from spatial scaffolds in the hippocampus rdcu.be/d7UYu - such cool work going on in computational neuroscience, connecting circuit designs to cognitive operations 👍

FDG

Symmetries and continuous attractors in disordered neural circuits https://www.biorxiv.org/content/10.1101/2025.01.26.634933v1

Nice to see Alzforum covering our most recent article in Science Transl Med and highlighting its importance for future lines of research and therapy! Special thanks David Jones and Tarick Pascoal for the great comments on our work! alzforum.org/news/research-…

Every large-scale functional unit in the brain that contributes to observable human behavior has an associated degenerative neurologic disease.

Another day as Doc4 quaternary referral after several tertiary evaluations found "some unknown degenerative condition" without doing a simple test for those. FDG-PET:

The mind is beyond physics, but it’s not beyond science.

Brain function is key to AD biology: doi.org/10.1093/brai...

FDG is a key clinical tool for all degenerative diseases of the mind.

My job.

here's, for example, a body-built behaviour without cognition

New year, new preprint (+ last thesis paper!) Macroscale gradients of intracranial EEG power spectra follow familiar axes: sensory-motor and unimodal-transmodal 🕵️‍♀️ Gradients show overall stronger association to distance, but multimodal information was best in transmodal areas 🧠 tinyurl.com/ykacndd5

We value things differently depending on the situation. A fascinating paper shows that the hippocampus feeds contextual information to the prefrontal cortex by altering theta wave phase alignment, enabling the PFC to adjust value judgments accordingly. www.nature.com/articles/s41... #neuroscience

Even more of Behavioral Neurology explained in one figure of FDG-PET data. Brain metabolism seems to give a key readout of fundamental neurobiology related to all degenerative diseases of the mind:

Combating Diagnostic Nihilism Neuro 🧠 Pt: I have “X” symptoms. Doc1: “X” isn’t treatable, so no need for more tests. Pt: How do you know? What is it? Doc1: Finding out is academic. No further tests Pt: I’ll get a second opinion. Doc2: Tests confirm ‘Y’. Let’s make a plan Pt: 🙏

FDG-PET was one of the 1st biomarker used to assess Alzheimer’s-related cognitive decline. With tau & amyloid PET tracers (yay!), FDG-PET has fallen out of favor. Sad bc there’s value in knowing how brain metabolism changes relative to AB, tau, glia, risk genes. www.sciencedirect.com/science/arti...

One of many ways to usefully prognosticate for patients using FDG-PET: www.sciencedirect.com/science/arti...

Fluid intelligence relates to neural measures of cognitive map formation https://www.biorxiv.org/content/10.1101/2024.12.28.630614v1

Human precentral gyrus neurons link speech sequences from listening to speaking https://www.biorxiv.org/content/10.1101/2024.12.27.630563v1

𝗗𝘆𝗻𝗮𝗺𝗶𝗰𝗮𝗹 𝘁𝗵𝗲𝗼𝗿𝘆 𝗼𝗳 𝗰𝗼𝗺𝗽𝗹𝗲𝘅 𝘀𝘆𝘀𝘁𝗲𝗺𝘀 𝘄𝗶𝘁𝗵 𝘁𝘄𝗼-𝘄𝗮𝘆 𝗺𝗶𝗰𝗿𝗼–𝗺𝗮𝗰𝗿𝗼 𝗰𝗮𝘂𝘀𝗮𝘁𝗶𝗼𝗻 Interesting paper but top-down causation seems to be way of capturing how micro-level entities respond to *aggregate state* of all other micro-level entities #complexity ht @evanthompson.bsky.social www.pnas.org/doi/10.1073/...

I have been thinking about ecological psychology a lot lately.

Help bluesky neurohivemind! If you know of any computational / theoretical work modelling neuromodulators please share it 🙏 if you don't, please retweet!

The human posterior parietal cortices orthogonalize the representation of different streams of information concurrently coded in visual working memory journals.plos.org/plosbiology/... #neuroscience

Organizing space through saccades and fixations between primate posterior parietal cortex and hippocampus www.nature.com/articles/s41... #neuroscience

Spending my days thinking about how to tackle delusional beliefs and confabulation, and evenings weaving a web of misinformation on behalf of the Elf on the Shelf