(@tnrlab.bsky.social)

My first Bluesky post! We found that shifting around polyubiquitin (using a chemical biology trick) results in altered #tau filament structure. The unstructured "fuzzy coat" of tau filaments matters!?! #AD #FTD #FTLD #cryoEM #Alzheimer #VCP #raredisease www.biorxiv.org/content/10.1...

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Repositioning of polyubiquitin alters the pathologic tau filament structure Structurally diverse tau filaments form proteinaceous aggregates in a heterogeneous group of neurodegenerative diseases called tauopathies1. The factors extrinsic to the highly ordered core structure ... https://www.biorxiv.org/content/10.1101/2025.05.02.651930v1