What I love most about this paper is not only the science but how it harnessed the collaborative energy of two amazing lab mates to create something really special. What a week by @juliabrunner.bsky.social 🥳

Absolutely gorgeous and meticulous work from @juliabrunner.bsky.social that has been so fun to brainstorm about over the years. Another important reminder that even ‘core’ metabolic pathways are often differentially wired across cell states!

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Thrilled that my thesis work in @lydiafinley.bsky.social's lab is out in the world! We found that methotrexate targets a specific metabolic vulnerability in a particularly aggressive form of pediatric rhabdomyosarcoma. Thank you to everyone who contributed to this project over the years!

Our latest preprint identifies (targetable!) metabolic programs intrinsic to different cancer cell states in rhabdomyosarcoma, out just in time for @katrinaparas.bsky.social's thesis defense tomorrow!

Thrilled that my first post here is this absolutely monumental work by @katrinaparas.bsky.social and the @lydiafinley.bsky.social lab. It’s been so much fun to watch this story develop; read it if you have any interest in cell state, pediatric cancer, or of course metabolism!