The main function of the TCA cycle is to feed electrons into the respiratory chain. ..wait, what!? It also clears excess citrate, because otherwise you get severe kidney damage? Great example that textbooks aren’t always the full story by Abby, @juliabrunner.bsky.social and @lydiafinley.bsky.social

@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇

Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Julia’s paper identifying Aspartate as a determinant cell-state specific engagement of the Malate-Aspartate-Shuttle is now out @cp-molcell.bsky.social!

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social bit.ly/4asbwO3

Critical role for a high-plasticity cell state in lung cancer @nature.com @mskcancercenter.bsky.social www.nature.com/articles/s41...

Polyamine-dependent metabolic shielding regulates alternative splicing @nature.com @cicbiogune.bsky.social www.nature.com/articles/s41...

@natmetabolism.nature.com turns 7! From our first issue in 2019 to our latest in Dec 2025, many thanks to the #metabolism community for your trust, support, and for allowing us to showcase your exciting work. We hope to continue serving the community and publish on all things metabolism! 🧪

Metabolism: How pyruvate controls cell size 🔗 eLife Insight Articles delve into the real significance of the latest research. Read here: buff.ly/F3gMKka.

The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor. The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2. www.leadingedgesymposium.org/apply/

Auszeichnung exzellenter österreichischer Wissenschaftler:innen in den USA: 3 Forschende erhalten heuer #ASciNA Awards für während ihrer Forschungsaufenthalte entstandene Publikationen: Wir gratulieren Caroline Moosmüller, Alexander Lercher u. Gabriele Wadlig! 👏 #BMFWF www.fwf.ac.at/aktuelles/de...

Innate immune memory is wild 🧠 Alexander Lercher from Rockefeller dives into how cells remember past infections and prep for future ones. Type I interferon doing way more than just fighting viruses! Full interview: buff.ly/5TKEJ9o #CytokineSociety #ImmuneMemory #TypeIInterferon #CellsHaveMemoriesToo

🚨 We're hiring! The Rendeiro Lab @cemm.oeaw.ac.at is looking for a data scientist or software engineer to work on open-source tools for spatial, histological & multimodal data. Ad: www.nature.com/naturecareer... More info: rendeiro.group

Extremely happy to be awarded the Sidney & Joan Pestka Post-graduate award! Thank you @cytokinesociety.bsky.social and all my mentors, colleagues and collaborators throughout my career so far!

Online now: The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines. Learn more about these exceptional scientists: www.leadingedgesymposium.org/fellows

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Postdoc Night Science NYC! Next session is Friday 4-6pm at MSK, to learn and practice the creative scientific process! The topic this time is the import/export of ideas. Yael David join us too! @davidlabmsk.bsky.social Limited spots: docs.google.com/forms/d/12bB... @kelseymonson.bsky.social

Postdoc Night Science NYC is coming to @mskcancercenter.bsky.social! #MSKPostdocs, come join Drs. @itaiyanai.bsky.social and @kelseymonson.bsky.social to explore and practice the creative scientific process. In this session, they will discuss how to import and export ideas across different fields.

First: I apologize for never coming here and now doing so only to brag 😬 Second: I am very proud of the people in our lab. We are a small group in a Bio department and this work took an enormous amount of effort from every one here. rdcu.be/eaxEz

I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC. I'm excited to come together, talk science, and support researchers in our field. www.cancermetabolismshowcase.org

Super proud of my bench mate and her work on differential metabolic dependencies in pediatric rhabdo; now online at @biorxiv-cancer.bsky.social - @katrinaparas.bsky.social who’s going to help me with cloning when you’re gone?!

Our latest preprint identifies (targetable!) metabolic programs intrinsic to different cancer cell states in rhabdomyosarcoma, out just in time for @katrinaparas.bsky.social's thesis defense tomorrow!

I hope you will join @lydiafinley.bsky.social and me for two days of great science on metabolic support of development and cell fate. Deadline for scholarships and short talk abstracts is Feb. 6.

What if we could look at a human tissue image🔬and quantify its biological age?🧬 And how could we get the same insights without collecting the tissue sample? In our new @biorxivpreprint, we create "tissue clocks" ⏳to do just that! www.biorxiv.org/content/10.1... 📝 #aging #tissue thread below⬇️

How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on.. Paper at Immunity: www.sciencedirect.com/science/arti...