Johannes Zuber (@johanneszuber.bsky.social)

A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,... https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-0679/766696/A-plastic-EMP1-to-LGR5-cell-state-conversion-as-a