I still love the theory a Year 6 child proposed to me that David Attenborough is actually God and he got fed up with people not noticing the amazing things he'd created, so he made documentaries to show off.

Very interesting articles about cancer metabolism this month, and insightful reviews. Highlighting fresh articles and comments about cysteine and glutathione from @lucasbsullivan.bsky.social @ginadenicola.bsky.social @harrislab.bsky.social and others metabolist.wordpress.com/2026/05/04/m...

It’s that time of the month! The ApoList newsletter Compilation of papers on cell death. Excellent reviews this time, and several outstanding papers about death receptor signaling and how it switches between “calm” (apoptosis) and “explosive” (necroptosis) celldeath.wordpress.com/2026/04/30/a...

The first section of this piece about whether PANoptosis exists is gold. Vince and Silke, Nat Rev Mol Cell Biol www.nature.com/articles/s41...

Infection-fighting T cells from people who have eaten recently can proliferate more quickly in response to threats via lipid metabolism @nature.com @delgoffelab.bsky.social @upmchillmancc.bsky.social www.nature.com/articles/d41... www.nature.com/articles/d41... www.nature.com/articles/s41...

I have yet to find an ATP-mimetic compound which 𝘤𝘢𝘯'𝘵 activate GCN2 at certain concentrations, including AMP-PNP, ATPyS, and even ADP. This is all in vitro with purified GCN2.

A PhD applicant emailed asking for a job and praised my work about how protein X regulates process Y. We have not published on that. I have not presented those data. AI use is getting CREEPY

Oh great. GCN2ib, one of our favorite GCN2 inhibitors, not only activates it a higher doses but it also inhibits MAP kinases An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity - JBC www.jbc.org/article/S002...

Ferroptosis

😰 good Monday morning exercise 😰 My two cents on this - ferroptosis is best understood as a terminal process that begins once lipid oxidative damage exceeds the cell’s buffering and repair capacity. Does it lead to cell death? Clearly yes.

Is ferroptosis a form of cell death? Or is it a process that ends up in apoptosis or in lysosomal cell death? It depends on who you ask. But we better agree on definitions, because there are clinical implications I would love your opinion @angelifriedmann.bsky.social www.cell.com/developmenta...

So cool to have Trends in Endocrinology and Metabolism highlighting research from the lab! Thanks @bdmanning.bsky.social @cp-trendsendomet.bsky.social www.sciencedirect.com/science/arti...

How do you know if a cell is senescent? It looks huge, positive for beta-gal. We thought that senescent cells don't regrow. By definition. But then we analysed palbociclib-induced "senescence" with the intention to kill mesothelioma cells with this drug www.nature.com/articles/s41...

Interesting work from the @gyrd-lab.bsky.social about the role of a non-translated region of TNF receptor 1

This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.

Literature on cell death from the past few weeks Focus on necroptosis as immunogenic cel death relevant in for cancer responses, also in stromal cells, by the Meier lab @ttenev.bsky.social @pmeier.bsky.social Apolist celldeath.wordpress.com/2026/03/20/a...

Perspective @cp-cellchembiol.bsky.social Transcending cell death – The diverse roles of necroptosis signal adaptors in pathogen infection www.cell.com/cell-chemica...

Interesting and systematic evaluation that consolidates many observations the field has already been converging on: GPX4 dependency appears to be overestimated in vivo. Suggesting that exploiting high-PUFA states in specific cancer entities is unlikely to benefit from single-target GPX4 inhibition.

RESEARCH | @crismunozp.bsky.social @idibell.bsky.social Glucose deprivation triggers secretion of cytokine LIF, which promotes angiogenesis and immune suppression in lung cancer models 🧪

Some public-health experts and science commentators were saying this at the time. For all the wonders of rapid tests and then vaccines, we could not science our way out of problems that were not science problems at their core.

Timeline cleanse: Baby tapir getting scritches for their itches. If you want to scritch your very own tapir & you live outside of Central or South America or SE Asia, you'll need to visit a zoo. But these little guys are (evolutionarily) from around here, in North America. Let's talk about it.

The landscape of regulated cell death: It’s all downhill from here: Molecular Cell www.cell.com/molecular-ce...

What happens when tumor cells can't find enough nutrients? They "call" other cells. We have found a new mediator of this phenomenon: the multifunctional cytokine LIF 👇🧵

This project started with confusion 🤔 www.nature.com/articles/s41... Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects. Neither LUBAC nor OTULIN had been linked to metabolic regulation. So where do these metabolic manifestations come from?

Cancer metabolism, papers from January 2026. Glycolysis, starvation, nutrient sensing, hypoxia, amino acids, cachexia, diet, lipids, cancer immune metabolism... MetaboList metabolist.wordpress.com/2026/02/09/m...

Latest articles on cell death: the ApoList Articles on apoptosis, pyroptosis, necroptosis and ferroptosis, and how dead cells interact with the microenvironment celldeath.wordpress.com/2026/02/09/a...

Someone told me earlier today that doing a tweetorial (or bluetorial) to highlight one’s scientific articles is “cringe”. Is it? I wanted to highlight our last article like this 🙁

As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway. 1/

Glucose deprivation drives LIF-dependent lung cancer @natmetabolism.nature.com @crismunozp.bsky.social www.nature.com/articles/s42...

We published something BIG and we collapsed it

****2-NBDG does not measure glucose uptake**** Just your regular reminder of this fact 😁. See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper. This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄 pmc.ncbi.nlm.nih.gov/articles/PMC...

The lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex.

Here’s a new compilation of papers about cancer metabolism published last month MetaboList - December 2025 Special section about diet and cancer metabolist.wordpress.com/2026/01/09/m...

First ApoList of the year. Loads of interesting papers about death receptors, RIP kinases, necroptosis, ferroptosis, and of course, Bcl-2 family proteins and apoptosis. Many, about important, non-apoptotic roles of caspases in human pathology Happy 2026! celldeath.wordpress.com/2026/01/08/a...

Happy Christmas from the Muñoz-Pinedo/Nadal lab in rainy Barcelona!

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Now online! HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion

I would

Alternative translational control by mTOR of cytokines like TNF and Interferon gamma through their 3' UTR

Good morning! (In Europe) Here's a selection of papers on cancer metabolism, cancer-inmunometabolism and cancer and diet and systemic metabolism (cachexia), as well as nutrient sensing and hypoxia. MetaboList, November 2025 metabolist.wordpress.com/2025/12/04/m...

This paper includes relevant #ISR & cancer info, like a role for GCN1-GCN2-ATF4 in metastasis of PAAD in several organs "Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth" aacrjournals.org/cancerdiscov...

A traditional weekly issue of BioMedNews on everything #CellDeath -related: biomed.news/bims-cediti/...

Several opportunities to join our group as a PhD candidate with bioinformatics or experimental background and interests in #microbiome, #Candida, or #evolution. 👉 IRB call: www.irbbarcelona.org/en/careers/y... 👉 Inphinit call: lacaixafoundation.org/en/doctoral-... 👉 EvoMG call www.evomg-dn.eu

Thiruptosis! Wasn't panoptosis enough?

Fast, ISR-independent repression of translation of “old” versus “fresh” RNA (5 min!) in glucose deprived yeast cells

Why, Nature, really? Because we're always right! Every husband knows

Ferroptosis induced by inhibition of GPX4 suppressed tumor growth in 2D, but not in 3D or in vivo. Lipids are different "Lipid Composition Alters Ferroptosis Sensitivity" aacrjournals.org/cancerres/ar...

“Know this”, he says. “The main function of reviewers and the Editorial process is to take your lovely, wonderful paper That you love so much, that you adore And convert it, step by step, into that which you will call ‘That frogging’ paper.

C'mon guys. Cells show blebbing and death was inhibited by caspase inhibitors and had mitochondrial permeabilization. In my alternate universe, this is apoptosis 🙄