New @nature.com The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills nature.com/articles/s41...

The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5

Interested in stable isotope infusions but daunted by jugular catheter surgery? New from postdoc @kimyumi0201.bsky.social: our simple tail vein catheter method enables anesthesia-free infusions in awake, freely moving mice. 🧵

Amid NIH funding delays, reversals and uncertainty, a scientist at Harvard who studies breast cancer has lost one-third of her lab employees and wonders if she can continue her research experiments. n.pr/4a4N3zD

Had a lovely time talking science with our peers at #MidwestMetabolism - until next year!! @palpurab.bsky.social @vipinrawat482.bsky.social @meteozgurses.bsky.social

If you’re at the Midwest Metabolism Meeting, make sure you stop by our posters! We have 6 lab members presenting today @meteozgurses.bsky.social @vipinrawat482.bsky.social @palpurab.bsky.social @juliannasupplee.bsky.social @linalietuv.bsky.social

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1 www.nature.com/articles/s41...

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti... !

Working on some very important, very serious experimental procedures…

@thermofishersci.bsky.social vendor show today 🤪 can you guess who unwillingly stood for the picture????

Latest lab photo from celebrating Dr. Coloff’s birthday earlier this month!!!! 🥳

Congrats to @meteozgurses.bsky.social for being selected to present his work at Chicago Mass Spec Day last month!!

🤩🤩🤩 @palpurab.bsky.social

Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer https://www.biorxiv.org/content/10.1101/2025.08.18.670862v1

The Hormone Dependent Cancer Gordon Research Conference got a sneak peak at Purab’s new work before it hits the journals - watch this space, publication dropping soon!!!! 👀 @palpurab.bsky.social

Even MORE exciting Coloff lab news!!! 🥳 after graduating with her PhD from Penn, @juliannasupplee.bsky.social has moved to Chicago to continue her work in cancer lipid metabolism with us as a postdoc!!! Welcome Julianna!!! 🤩

Join us in at Moffitt! The Metabolism Program is recruiting at the Assistant Member (Assistant Professor) level. Review of applications starts September 1st. Please share! Details here: moffitt-cancer-center-careers.hctsportals.com/jobs/1883440...

We also have to give a shoutout to @linalietuv.bsky.social for completing her preliminary exam!! She will now enter the next phase of her program: PhD candidacy 😱

EXCITING COLOFF LAB NEWS: Philippa successfully defended her thesis, “Serine Starvation Modulates mRNA Splicing Through Depletion of SR Proteins,” last month and is officially Dr. Burns!!! Congratulations Philippa!! 🍾

We had the pleasure of hosting Christian Guerrero, a high school student part of @uicancercenter.bsky.social CHESS program, for several weeks this summer. Thank you Christian for your curiosity and hard work, and we can’t wait to see what you do in your future!!

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

From Nobel prize winning cancer researcher Bill Kaelin Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...

Congrats to Rushika and Gilles on this really cool work!

1/3 PLEASE READ, LIKE, REPOST this "1/3" post There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)

Coloff lab 🤝 AACR

Last but not least, Mete will be presenting his work at this afternoon’s poster presentation as well. Make sure to check him out!! @meteozgurses.bsky.social

Loooooove single cell RNAseq???? So does Lana! Come talk with her at her poster in the afternoon session #AACR25

Make sure to stop by our resident ceramide nerd’s poster tomorrow between 9-12!

Curing cancer one SRSF at a time #AACR25

Philippa will be presenting her thesis work this afternoon at 3:20 in room E450B. Make sure to stop by and see her talk one last time before she defends in July!

“It’s tiiiiiiiiiiiiiiiiiiiiiiiime!” -Mariah Carey #AACR25

Hi everyone! My name is Lina Lietuvninkas and I’m a second year graduate student in the Coloff lab 👩‍🔬 Jon gave me access to this account so many of the posts will be from me. Let’s see how long it takes for him to regret this!!

ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n

We also presented our latest research at @uicancercenter.bsky.social Gary Kruh Cancer Research Symposium! Purab Pal PhD, Vipin Rawat PhD, Mete Ozgurses, and Lana Semina PhD, all presented posters of their work. Make sure to check them out again at @theaacr.bsky.social annual meeting this week!

We had the opportunity to attend @asbmb.bsky.social annual conference in our hometown last week!! We listened to some very interesting talks, got to dig deeper into the biochemical nature of our work, & got to make our own buttons 🤓 Can’t wait to show them off at @theaacr.bsky.social next weekend!

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer. www.science.org/doi/10.1126/...

Check out this great new work from the @muirlab.bsky.social on the role of nutrients in the TME impacting tumor metabolism and therapeutic vulnerabilities!

ATTENTION The Washington Post is collecting data about funding issues. Please consider contributing. thewashingtonpost.formstack.com/forms/scient...

NIH indirects case update: Hearing ongoing now, and I'll try to live tweet some notable exchanges. Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides: (I'm paraphrasing here)

A restaurant might be a useful analogy for explaining direct vs indirect costs: Direct costs pay for the day's ingredients and the wages of the cooks. Indirect costs pay for the kitchen. Both are essential, but they need to be managed differently. Which is why they are separate.

We’re hiring a #postdoc! The Dibble Lab at Harvard Medical School and Beth Israel Deaconess Medical Center in Boston studies the regulatory relationship between #signaling and #metabolic pathways. Email me at [email protected] !

I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC. I'm excited to come together, talk science, and support researchers in our field. www.cancermetabolismshowcase.org

This is just a reminder that the #cancermetabolism and #mitochondrialbiology community is ever-growing, and the third starter pack is becoming very juicy. Starter pack 1: go.bsky.app/VavECSX Starter pack 2: go.bsky.app/CH1MctZ Starter pack 3: go.bsky.app/7Uwa6fb