happy to announce that i have post-doc openings for mid-2016 to advance this science please read our work, think about the most exciting questions & approaches, & be in touch for an interview note that there are now human data in support of our model www.medrxiv.org/content/10.6...

RESEARCH | @charlesmbrenner.bsky.social et al @cityofhope.bsky.social In citrin deficiency, accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction🧪

thank you, Christian thanks to @russgoodman.bsky.social @markhermanmd.bsky.social @cnspracklen.bsky.social Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others

heading to helsinki to join @keisakamoto.bsky.social @awartiovaara.bsky.social and others at tuesday's SWAN meeting: healthy aging, mitochondrial disease, MASLD, rare disease and more!

Congrats on this exciting new work! Uncovering how glycerol-3-phosphate activates ChREBP, FGF21, and lipogenesis in Citrin Deficiency adds valuable insight to metabolic regulation. Looking forward to seeing how this advances the field! 🚀🧬👏

@charlesmbrenner.bsky.social nice podcast with Drs Nadolsky

happy to say i got a completely routine email today requesting that i ad hoc on an april 2 study section

thank you, Paul IMO the mystery is why more folks don't call BS when it is so plain to see and why editors continue to review papers from groups that are obfuscatory

The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety: www.biorxiv.org/content/10.1...

The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety: www.biorxiv.org/content/10.1...

jackson state really brings it

I’m celebrating tonight with my father in law, Jack Strominger, who is about to enjoy his 100th New Years! He wants to know whether any other scientist has published in their 100th year. He’s proud to have a paper in the works. I told him you all would know! Please RT

happy newyearsnukkah 🕎

may it be so again!

for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....

Just to add to the sad news on #chemsky right now: I've now had it confirmed to me that Martin Karplus died on Saturday.

I convert tax dollars to pdfs

www.biorxiv.org/content/10.1... Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency www.biorxiv.org/content/10.1...

all..... i will fix the post with working links soon as i can

Congrats on the new work, Charles! 🎉 Excited to dive into your findings on ChREBP and FGF21. Your research always brings fresh insights to the table! Keep up the amazing work! #ResearchInnovation #Biochemistry

excited to share new work "Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency" www.biorxiv.org/content/10.1...

Just when it seemed we had uncovered everything about Nampt, the rate-limiting enzyme in salvage NAD+ biosynthesis, first author Shu Feng in @charlesmbrenner.bsky.social lab and colleagues reveal an exciting discovery: Nampt is a protein phosphoribosylase! www.nature.com/articles/s42...

yes, refreshing article still a major problem as one small example, @davidasinclair.bsky.social just gave a talk on aging at ARDD he talked about work in a Cell paper that James Timmons & i said should be retracted cell didn't retract but eventually published our critique w a response from david

Mito disease management is largely symptomatic. A subset respond well to specific vitamins or cofactors, but evidence of benefit in most is poor although prescribing is common. A survey of global vitamin & cofactor prescribing practices in PMD. 👉 doi.org/10.1002/jimd... @jhpark.bsky.social

Some inner ear hair cells for #FluorescenceFriday. A new audience for an old image. 🧪👂 #cilia #neuroskyence

the brenner-knoller dogs

where’s metabolism? jk it’s everywhere

Today in relatable science: Gulls making a mysterious daily trip that turned out to be to a potato chip factory

i’m a metabolism scientist at city of hope who can’t stop thinking about NAD coenzymes have some exciting results on a rare disease as well what interests you?

who is ready for #NADtwitter?

the woozle effect so powerful in forming the mythology that sirtuins are longevity genes examples here doi.org/10.1093/life...