Charles Brenner, PhD
@charlesmbrenner.bsky.social
π€ 1361
π₯ 377
π 74
NAD metabolism truth in science
pinned post!
thank you, Christian thanks to
@russgoodman.bsky.social
@markhermanmd.bsky.social
@cnspracklen.bsky.social
Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others
add a skeleton here at some point
27 days ago
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reposted by
Charles Brenner, PhD
Nature Metabolism
29 days ago
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Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
Nature Metabolism, Published online: 14 November 2025; doi:10.1038/s42255-025-01399-3In a mouse model of the rare disease citrin deficiency, the authors discovered that the accumulation of glycerol-3-phosphate leads to ChREBP activation and FGF21 induction. The study identifies glycerol-3-phosphate as a ChREBP-activating ligand, which could resolve paradoxes of FGF21 expression and clarify the logic of lipogenic transcription.
https://bit.ly/49DpPAD
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thank you, Christian thanks to
@russgoodman.bsky.social
@markhermanmd.bsky.social
@cnspracklen.bsky.social
Vinod Tiwari, Olivia Sun and Edwin Lopez Gonzalez from my lab, Byungchang Jin in Russ's lab, Hardik Shah and others
add a skeleton here at some point
27 days ago
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heading to helsinki to join
@keisakamoto.bsky.social
@awartiovaara.bsky.social
and others at tuesday's SWAN meeting: healthy aging, mitochondrial disease, MASLD, rare disease and more!
4 months ago
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reposted by
Charles Brenner, PhD
TYice
5 months ago
Congrats on this exciting new work! Uncovering how glycerol-3-phosphate activates ChREBP, FGF21, and lipogenesis in Citrin Deficiency adds valuable insight to metabolic regulation. Looking forward to seeing how this advances the field! ππ§¬π
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Charles Brenner, PhD
10 months ago
@charlesmbrenner.bsky.social
nice podcast with Drs Nadolsky
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happy to say i got a completely routine email today requesting that i ad hoc on an april 2 study section
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11 months ago
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thank you, Paul IMO the mystery is why more folks don't call BS when it is so plain to see and why editors continue to review papers from groups that are obfuscatory
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11 months ago
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reposted by
Charles Brenner, PhD
Logan F. Cheng
11 months ago
The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety:
www.biorxiv.org/content/10.1...
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Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1
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reposted by
Charles Brenner, PhD
Logan F. Cheng
11 months ago
The doi segment of the first link in the thread's url was cutoff; here's the link in its entirety:
www.biorxiv.org/content/10.1...
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Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1
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jackson state really brings it
12 months ago
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reposted by
Charles Brenner, PhD
Stirling Churchman
12 months ago
Iβm celebrating tonight with my father in law, Jack Strominger, who is about to enjoy his 100th New Years! He wants to know whether any other scientist has published in their 100th year. Heβs proud to have a paper in the works. I told him you all would know! Please RT
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reposted by
Charles Brenner, PhD
Tal B. Lavin
12 months ago
happy newyearsnukkah π
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may it be so again!
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12 months ago
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reposted by
Charles Brenner, PhD
Benoit Bruneau
12 months ago
for some reason down a rabbit hole of mid-80s-mid 2000s discoveries (Leptin, Orexin, Growth Hormone production, cold receptor, p21 KO mouse, human iPSCs, etc) and realizing that they were all accepted less than two week after submission. Orexin in 4 days! Those were the days....
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reposted by
Charles Brenner, PhD
Laura Howes
12 months ago
Just to add to the sad news on
#chemsky
right now: I've now had it confirmed to me that Martin Karplus died on Saturday.
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reposted by
Charles Brenner, PhD
samuel mehr
12 months ago
I convert tax dollars to pdfs
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reposted by
Charles Brenner, PhD
Russell Goodman
12 months ago
www.biorxiv.org/content/10.1...
Excited that we could be part of this collaboration with the Brenner lab identifying that G3P is the metabolite that ChREBP directly senses!
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Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1
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reposted by
Charles Brenner, PhD
bioRxivpreprint
12 months ago
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1
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reposted by
Charles Brenner, PhD
Anupam Patgiri
12 months ago
Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
www.biorxiv.org/content/10.1...
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Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD...
https://www.biorxiv.org/content/10.1101/2024.12.27.630525v1
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all..... i will fix the post with working links soon as i can
12 months ago
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reposted by
Charles Brenner, PhD
12 months ago
Congrats on the new work, Charles! π Excited to dive into your findings on ChREBP and FGF21. Your research always brings fresh insights to the table! Keep up the amazing work! #ResearchInnovation #Biochemistry
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excited to share new work "Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency"
www.biorxiv.org/content/10.1..
.
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https://www.biorxiv.org/content/10.1..
12 months ago
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reposted by
Charles Brenner, PhD
Mike Cohen
about 1 year ago
Just when it seemed we had uncovered everything about Nampt, the rate-limiting enzyme in salvage NAD+ biosynthesis, first author Shu Feng in
@charlesmbrenner.bsky.social
lab and colleagues reveal an exciting discovery: Nampt is a protein phosphoribosylase!
www.nature.com/articles/s42...
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Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins - Nature Metabolism
The NAD+ synthesis enzyme NAMPT is shown to possess additional enzymatic activity as a phosphoribosylase, which restricts the virion incorporation of viral proteins and underpins its antiviral effect
https://www.nature.com/articles/s42255-024-01162-0
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yes, refreshing article still a major problem as one small example,
@davidasinclair.bsky.social
just gave a talk on aging at ARDD he talked about work in a Cell paper that James Timmons & i said should be retracted cell didn't retract but eventually published our critique w a response from david
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12 months ago
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reposted by
Charles Brenner, PhD
Journal of Inherited Metabolic Disease
about 1 year ago
Mito disease management is largely symptomatic. A subset respond well to specific vitamins or cofactors, but evidence of benefit in most is poor although prescribing is common. A survey of global vitamin & cofactor prescribing practices in PMD. π
doi.org/10.1002/jimd...
@jhpark.bsky.social
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about 1 year ago
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reposted by
Charles Brenner, PhD
Dan Jagger
about 1 year ago
Some inner ear hair cells for
#FluorescenceFriday
. A new audience for an old image. π§ͺπ
#cilia
#neuroskyence
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the brenner-knoller dogs
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about 1 year ago
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whereβs metabolism? jk itβs everywhere
about 1 year ago
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reposted by
Charles Brenner, PhD
Brooke Jarvis
about 1 year ago
Today in relatable science: Gulls making a mysterious daily trip that turned out to be to a potato chip factory
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about 1 year ago
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about 1 year ago
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iβm a metabolism scientist at city of hope who canβt stop thinking about NAD coenzymes have some exciting results on a rare disease as well what interests you?
about 2 years ago
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who is ready for
#NADtwitter
?
about 2 years ago
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the woozle effect so powerful in forming the mythology that sirtuins are longevity genes examples here
doi.org/10.1093/life...
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about 2 years ago
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you reached the end!!
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