Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025...

🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis. bit.ly/3RaRwWY

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...

Lipidome, proteome, LSD. What’s not to love??

Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....

So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd

Thank you Brian !!

Honored to be a 2025 Sloan Research Fellow! #sloanfellow

Pondering a purge of pesky pathological proteins?

Oh no, they said “bias” in the title: AI-mediated desk rejection at NSF www.nature.com/articles/s41...

Honored to be giving a talk at Dana-Farber’s TPD seminar this Thursday 2/6 at 9am PST. dfci.zoom.us/webinar/regist… Come check out MrTAC 💊 @danafarber.bsky.social

CRISPR screening in epithelial cells suggests that peroxisome-derived ether lipids alter cellular viability in response to lipotoxic stress. Fas-associated factor family member 2 (FAF2) appears to be a key regulator of this process. This is an interesting preprint! www.biorxiv.org/content/bior...

Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction www.biorxiv.org/content/10.1...

"An early-life microbiota metabolite [peroxisome proliferator-activated receptor γ, or PPAR-γ] protects against obesity by regulating intestinal lipid metabolism [in mice]" www.sciencedirect.com/science/arti...

... And if you want to know more, here's the featured Article: Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins ($) doi.org/10.1038/s415...

Our December issue has been out for a new weeks but it has quite a striking confocal microscopy image on the cover. www.nature.com/nchembio/vol...

Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...

Loving #CellBio2024 and excited to present in micro session MONDAY 10:30 AM 28C microsession #MrTAC #lysosome #degrader #TPD #methylation

Excited to attend ASCB #CellBio2024! The Albrecht lab will present on lysosomes, quality control, lipid / carbohydrate metabolism, and MrTAC TPD targeted degrader. Please check out our lab's talks and posters:

A new #ScienceAdvances study demonstrates a vaccine for cancer immunotherapy that would speed up the efficiency of messenger RNA translation in cytoplasm—and effectively inhibited tumor growth. scim.ag/49qY0sY

Dream come true to be featured on the cover!

Thank you @haoyin.bsky.social !!

Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨