Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling | Science www.science.org/doi/10.1126/...

It’s hard to focus lately and feels wrong to talk about science when the whole system is under threat, but I’ve been reading Hans Krebs’ autobiography and it’s excellent. I highly recommend for all scientists, especially biochemists

Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1

CRISPR screening in epithelial cells suggests that peroxisome-derived ether lipids alter cellular viability in response to lipotoxic stress. Fas-associated factor family member 2 (FAF2) appears to be a key regulator of this process. This is an interesting preprint! www.biorxiv.org/content/bior...

To my reading, this paper suggests a role for 'classic' #ferroptosis mechanisms (namely LPCAT3 and oxPL) in ASCVD in humans www.jlr.org/article/S002...

Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados! Feel free to share, add and distribute, so we can come together again! 😍 go.bsky.app/AEeXh86

I have initiated this #StarterPack with #RedoxBio researchers. Feel free to suggest other users, or yourself, to be included! go.bsky.app/UoVRtXp

#StartPack for the #Ferroptosis researchers community. A small but growing list—let’s expand it together! Please, feel free to reach out if you'd like to be added or removed. 🧪🔬 go.bsky.app/35UvtTi

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

mTORC1 activity licenses its own release from the lysosomal surface www.cell.com/molecular-ce...

NLRP1 is activated by palmitic acid and induced in human metabolic dysfunction-associated steatohepatitis https://www.biorxiv.org/content/10.1101/2024.11.11.622769v1

This is a really interesting new preprint by Peter Tontonoz's group at UCLA. They discover a PPARγ–LPCAT3 pathway that links dietary n–6 PUFA intake to adipose expandability and systemic energy balance through unique storage of triglycerides. www.biorxiv.org/content/10.1...

This was a good read - some very exciting translational science! "The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans"

Porphyromonas gingivalis is a gram-negative anaerobic bacterium which is commonly found in the oral cavity and has been implicated in the pathogenesis of chronic periodontitis, but is also associated with other conditions such as bacterial vaginosis and Alzheimer’s disease. Here, we perform ...

This summer I worked on a rotation project looking at the role of arachidonic acid (AA) remodeling into macrophage phospholipids in atherosclerosis, a topic about which there’s some interesting literature dating back to 1994 (PMID: 8181456)....

A very interesting idea: could adipose tissue cellularity be regulated by the terminal complement cascade? I’ve never thought about any components of the innate immune system in adipose tissue that weren’t macrophages…. www.nature.com/articles/s41...