@labhofmann.bsky.social
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reposted by
The Australian Ubiquitin Summit
13 days ago
‼️It was wonderful to have Professor Kay Hoffmann at the
#AusUb25
- and even better to get the chance to interview him! Hear about his experiences in industry and academia as well as his love for proteins😁
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reposted by
Nature Structural & Molecular Biology
17 days ago
ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
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UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Nature Structural & Molecular Biology, Published online: 05 December 2025; doi:10.1038/s41594-025-01717-zRiechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2 ubiquitin-conjugating enzymes, revealing a hierarchy of E2 activity with cognate E1s.
https://go.nature.com/4iLNfGu
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For all
#ubiquitin
aficionados out there: Our new study, where we used an
#alphafold
based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane.
www.biorxiv.org/content/10.6...
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DUCs are C2 domain containing plant-specific deubiquitinases stabilizing endocytic cargo at the plasma membrane
Deubiquitinases (DUBs) remove ubiquitin modifications from proteins in a substrate- or linkage-selective manner and regulate numerous cell-biological processes, including endocytosis. By performing ho...
https://www.biorxiv.org/content/10.64898/2025.12.04.692294v1
18 days ago
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