It's clear that most people don't read to learn, to enjoy. They read to sound smart, appear clever, and tell others they've read so and so "classic" writers. They lose twice: They don't enjoy something enjoyable. And it debases their hearts and closes their minds.

Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...

A study in Nature finds that five groups of disorders share most of their genetic risk in a screen of 14 psychiatric conditions, including depression, anxiety, and schizophrenia. The findings could help to improve diagnoses and lead to new treatments that work across several conditions. 🧬 🧪

Top #Altmetric 2025: 7️⃣🧪 @pkapahi.bsky.social et al ( @buckinstitute.org#Altmetric) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.

🚀 Postdoc opportunity! The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈 👉

The Kapahi Lab is looking for two creative, motivated postdocs to join our team. We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging. [email protected]

#Throwback 🧪 REVIEW | The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research S Deota, S Panda et al.

Thrilled to share our new paper! With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste. Link @nature.com: www.nature.com/articles/s41...

#Throwback 🧪 REVIEW | Cellular and organismal function of choline metabolism M Abu-Remaileh, K Birsoy et al.

Deadline closing soon! Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research. 📅 Deadline: Dec 10, 2025 🔗 age.memberclicks.net #AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience

Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men) nature.com/articles/s44...

The war zone in Portland is out of control.

Can a cocktail of glycation-lowering compounds curb #hunger, lower #insulin resistance and extend #lifespan? It does in mice! Buck scientists fight the sugary chemistry of #aging. www.buckinstitute.org/news/glycati... @cp-cellreports.bsky.social, @pkapahi.bsky.social

Had a wonderful time at the Barshop aging Meeting at Banderas!

The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

“How we spend our days is, of course, how we spend our lives.” Annie Dillard

Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees. That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional. www.nytimes.com/2025/10/01/o...

Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).

Congratulations to Rachel Buckley @bucklr01.bsky.social on being a finalist for a National Association of Science Writers @sciencewriters.org award. Read Rachel's essay, www.thetransmitter.org/sex-differen... #neuroskyence

thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.

#vss365 The world may be going to Hell in a handbasket, but there are still beautiful sunsets, autumn colours, and birdsong. And in any #eventuality, somewhat may, there will always be love.

Reviewed as a ‘fundamental’ discovery, this study identifies lymphatic muscle cells as innate pacemakers driving lymphatic pumping. buff.ly/kWvdl5i

about the $100K H1B fee, here's some interesting details: "If an employee is in the U.S., he or she will not be subject if (i) applying to extend or amend H-1B status, or (ii) applying to change from another visa category into H-1B status from within the U.S."

Early #puberty and early childbirth may come with a cost. Study in @elife.bsky.social shows reproductive timing can accelerate aging and disease, quadrupling the risk of severe metabolic disorders. Congrats @pkapahi.bsky.social www.buckinstitute.org/news/early-p...

RESEARCH | 🧪 S Bar, ‪ @pkapahi.bsky.social et al @buckinstitute.org Neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster www.nature.com/articles/s42...

Neurons burn #sugar differently. The discovery from the Kapahi lab could save the brain. Study in Nature Metabolism provides new approach in #Alzheimers research and could explain why #GLP1 drugs show promise against #dementia buckinstitute.org/news/neurons... @pkapahi.bsky.social

Cannot emphasize this too strongly.

link.springer.com/article/10.1... Delighted to be part of this collaborative effort

THIS IS HUGE! Researchers at Memorial Sloan Kettering Cancer Center say results of a Phase I trial of an mRNA vaccine aimed at preventing pancreatic cancer show promise. The vaccine PREVENTED the cancer from coming back in patients who had already received treatment for MORE THAN three years. 🧪🧵⬇️

Type 2 diabetes alters cerebral blood flood, glucose metabolism, and fatty acid metabolism. APOE4+ have increased fatty acid metabolism independent of T2D. link.springer.com/article/10.1...

Funded PhD Studentship available in my lab at @lsiexeter.bsky.social. Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply! lsi.exeter.ac.uk/groups/hendr...

Much of the Trump administration’s agenda for research is laid out in the 900-plus-page Project 2025. Nature examines science-related policies from Project 2025 that have already come to pass, and which ones might be on the horizon. 🧪

I'm so amped by all the positive energy, brilliant creative signs, and seeing so many people across the country #StandUpForScience! Let's use this motivation to stay loudly in this fight. Every small action matters

Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse! Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...

How do you find the gorilla hiding in your data? The "Postdoc Night Science NYC" club meets for the second time next Thursday to discuss this at NYU. The response so far has been overwhelming but there are probably a few more spots if you can join us! docs.google.com/forms/d/1Shc...

Expert's Dilemma: the more specialized you become, the less open you are to creative solutions from other fields. But the more you explore other fields, the more you risk losing credibility in your home field. Interdisciplinary work is still not really embraced by academia.

PhD students: it’s a waste to just try to impress your committee at the meeting. Bring them problems, ask for suggestions, and generally think of it as a session in which new ideas can emerge.

Research involves day science and night science, requiring you to become good at both. Day science proceeds in logical steps and specializes in hypothesis testing, but to generate new ideas we pop out to the creative night science world, where leaps among ideas are made possible.

Knowing how to give a good talk is a crucial skill to have, but it's mostly not formally taught very well. Here's my strategy for how to prepare for the presentation, actually present it, and then answer the questions.

If you haven't already, make a donation to Wikipedia - help sustain a great resource while pissing off the Nazi who bought the presidency

Only 2 more days to apply for our Early Career Scholars Program! Don't miss out on this great opportunity!

Now more than ever It is vital that we educate people about how research on model organisms had been fundamental in advancing our understanding of genetics, development, and cell biology, and this discovery driven research is foundational for disease focused studies. Consider these 8 Nobel Prizes: