Together with mammalian KSR1/2 and budding yeast Ste5, our discovery of Sms1 demonstrates the #evolutionary #convergence of the MAPK scaffolds in opisthokonts, with the independent acquisition of MAPK affinity and plasma membrane targeting domains.

IU let them lock the labs without notice and the occupants had to beg to make sure equipment was turned off and experiments running taken care of to, you know, not cause the building to burn down

Site-specific, multi-kilobase insertions and over-writes in mammalian cells, without DSBs, HDR, recombinases, integrases, transposases, or active cell cycling? Using fully or predominantly single-stranded DNA donors? 1/15

Meet MagLuc: a magnetically-controlled luminescent protein. This is a foundational tool for remote control of biological processes, also known as "magnetogenetics". Can you tell when the magnetic field turns on and off? From @mariaingaramo.bsky.social and the team at @nonfictionlabs.bsky.social

New review on optogenetics in development is out in @genesdev.bsky.social with @toettch.bsky.social and Yang Gao! 💙💡🔦 genesdev.cshlp.org/content/earl... We aim to capture why opto is such a powerful tool for devbio and how future advances can make it even better. Some highlights:

The number of NIH competitive awards is down 50% from 2025, and down ~70% from prior years. Even if they catch up by the end of the year, only wealthy institutions can bridge these huge funding gaps.They're killing science-and violating the constitution-by weaponizing the bureaucracy

Quantum biological control, now in a multicellular organism! Super exciting to see this work from @scburd.bsky.social et al 🧪

Wondering what's the difference between Halorhodopsin and Channelrhodopsin? Curious how a plant photosensor domain could power your next gene editing experiment? Check out our Optogenetics Guide to learn about these tools and more to light up your lab! 🧠💡🔬

Ribosome Molecular Aging Shapes Translation Dynamics www.biorxiv.org/content/10.6...

daily #pokemon doodle 218 - #Slugma in a @beetlemoses.bsky.social style comic

Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday. Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.

Our new paper just out! pubs.acs.org/doi/10.1021/...

Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published! Huge thank you to the many many people involved in making this happen. 🧪 www.nature.com/articles/s41...

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...

Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory. Check the list of other available projects on our website: lnkd.in/gEMXNQY6 The application portal is open so apply now! #PhD #IMPRS #graduateprogram #maxplanck

Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches" www.janelia.org/content/lead...

So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵

The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj

Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it? Turns out we can harness the power of bacteria to power the world’s smallest machines. 1/7 ⚛️🧪

Great Job - Great Colleagues - Great Science👍 Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows Relocation to DC is required, perfect for academic PIs looking for their next chapter hhmi.wd1.myworkdayjobs.com/External/job...

Want to get started with smart microscopy? 🧠🔬 Check out our online repository with implementations from labs and industry -- lots of practical tips and links to sample code! smartmicroscopy.github.io/implementati... More details in the ✨updated preprint!✨ www.biorxiv.org/content/10.1...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy. www.science.org/doi/10.1126/...

Very excited to be co-organizing this meeting next February. Fellow collective behavior enthusiasts, this one is for you!

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

🤩Wow huge opportunity alert!

And for your Friday afternoon, some in vivo ERK and RTK biosensor eye candy :)

NIH will only accept six applications per PI per calendar year. drugmonkey.wordpress.com/2025/07/17/n...

I was explaining to my Ukrainian colleague the phrase ‘There’s no such thing as a free lunch’. She told me the equivalent in Ukrainian is ‘The only free cheese is in the mousetrap’ - which is so much better

Two new preprints from the @arjunraj.bsky.social‬ on #gastruloids. Both excellent. Exploring the relationship between macroscopic reproducibility v microscopic heterogeneity. Stunning experiments and much to think about biorxiv.org/content/earl... biorxiv.org/content/earl...

Beautiful work on the development of protein kinase reporters. Congrats all! www.nature.com/articles/s41...

We built pYtags to detect RTK activity in Drosophila embryos and used them to learn about how developmental patterns form bsky.app/profile/emko...

Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...

Nature research paper: Spatiotemporal orchestration of mitosis by cyclin-dependent kinase https://go.nature.com/444lRhe

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. www.biorxiv.org/content/10.1...

This is incredible.

This is a beautiful paper first authored by a (brilliant) Princeton undergrad!

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

“Punk isn’t a hairstyle; it’s getting your friends together to make useful stories outside approved systems” www.nytimes.com/2025/05/11/o...

I talked to Nature about the latest development at NSF, which is a five-alarm fire for American science. The scale of immediate impact is massive. We narrowly escaped this affecting @viralemergence.org for now, but will have to shut down in a few months if this stays. www.nature.com/articles/d41...

I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao! www.biorxiv.org/content/10.1... We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?

Our field has lost an amazing scientist, mentor, and old friend. Benny, along with Mike Hoffman, had a brilliant idea in the early 1980s. The first oncogenes were being cloned and they realized if we wanted to understand their roles in cancer, we needed to understand their normal function 1/n 🧪

Unbelievable. Richard Youle, winner of the Breakthrough Prize for Life Sciences, just got fired from the NIH. If you want to know what madness looks like, here it is, my friend.

One more way the administration is helping the bond market.

People/organizations with means and a vision for the future of biomedical science - we need an “Arc Institute” equivalent in the DMV area to sponge up all the incredible talent, opportunity of a lifetime for a visionary entrepreneur, I will help! @mcuban.bsky.social

I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.

I always come home from conferences with swag for the kids and it’s usually a hit. This one was met by a 5-minute giggle fit and two “No, thank you”s. 😅😂

Interaction between two cells is necessary and sufficient to initiate PCP sorting😀, as shown by Lena P. Basta, Bradley W. Joyce, Dr. Eszter Posfai @eposfai.bsky.social , and Dr. Danelle Devenport. Here is the article. www.science.org/doi/10.1126/...